• Biomolecules & Therapeutics
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• v.24 no.3
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• pp.305-311
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• 2016

Mitochondria-targeted vitamin E (MVE) is designed to accumulate within mitochondria and is applied to decrease mitochondrial oxidative damage. However, the protective effects of MVE in skin cells have not been identified. We investigated the protective effect of MVE against UVB in dermal fibroblasts and immortalized human keratinocyte cell line (HaCaT). In addition, we studied the wound-healing effect of MVE in animal models. We found that MVE increased the proliferation and survival of fibroblasts at low concentration (i.e., nM ranges). In addition, MVE increased collagen production and downregulated matrix metalloproteinase1. MVE also increased the proliferation and survival of HaCaT cells. UVB increased reactive oxygen species (ROS) production in fibroblasts and HaCaT cells, while MVE decreased ROS production at low concentration. In an animal experiment, MVE accelerated wound healing from laser-induced skin damage. These results collectively suggest that low dose MVE protects skin from UVB irradiation. Therefore, MVE can be developed as a cosmetic raw material.

• Journal of KSNVE
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• v.11 no.1
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• pp.125-131
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• 2001

There is a clearance between the parts of a machine due to design tolerance, manufacturing error, wear, looseness, or misalignment. If the clearance is large, the vibration and noise of the machine is generally large. Therefore, the analysis on the nitration and noise of a machine can tell the clearance of the machine, which reveals the condition of the machine, i.e., the existence of faults and the safety of the machine. The investigation of this kind of research should be on the basis of experimental results. A link mechanism with a clearance at a joint between the coupler and locker is made for the investigation of the condition monitoring of a machine due to clearance. The vibration and sound are measured from the link driving system during the operation. The signals are clarified using line enhancement technique. The noise removed signals are used to develop the dynamic model of the system for a model based fault diagnosis. Also this study showed that the clarified signals can be used for the calculation of the joint forces between the coupler and rocker and for the correlation between the vibration and sound levels and the clearance sizes.

• Proceedings of the Korean Nuclear Society Conference
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• 1997.05a
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• pp.484-488
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• 1997

Fission product release (FPR) assessment for 100% reactor outlet header (ROH) break in CANDU reactor loaded with CANFLEX-NU fuel bundles has been performed. The predicted results are compared with those for the reactor loaded with standard 37-element bundles. The fuel failure thresholds for the CANFLEX and standard bundle elements are very similar. All the sheaths at the corresponding fuel failure thresholds for the CANFLEX and standard bundles fail due to the significant cracks in the surface oxide, except those for the CANFLEX inner element at burnups of 220 to 240 MW.h/kg(U), which fail due to the excessive diametral strain. The fuel failure analysis predicts that the number of failed fuel elements for the CANFLEX bundle case is none, while that for the standard bundle case is 1827. The total (gap plus bound) I-131 releases for the CANFLEX and standard bundles are none and 5889 TBq, respectively The significant reduction of the number of failed fuel elements and FPR for the CABFKEX fuel bundle is attributed to the lower linear power of the CANFLEX fuel bundle compared with the standard fuel bundle.

• Restorative Dentistry and Endodontics
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• v.13 no.1
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• pp.131-137
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• 1988

The purpose of this study was to investigate the interfacial bond strength of repaired composite resins, Lite-Fil P and Bis-Fil II, under different interfacial conditions. The matured composite resin specimen were prepared as Table I and divided into 9 groups. All specimens were stored in distilled water at $37^{\circ}C$ for 24 hours before testing. The results were as follows; 1. The bond strength of the groups that bonding agent was applicated was greater than that of the groups that bonding agent was not applicated. 2. The bond strength of the saliva contaminated groups was the lowest. 3. The bond strength of the group that chemical cured composite resin bonded to chemical cured composite resin was greater than that of the other groups. 4. The bond strength of the no-treated group was greater than that of saliva contaminated group, and lesser than that of the bonding agent applicated groups.

• Korean Journal of Microbiology
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• v.9 no.4
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• pp.163-168
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• 1971

Neutral protease which was obtained from a genus of Aspergilli as the crystal form were investigated for their purification and properties. The results of biochemical and enzymatic studies for their purification and properties in this enzyme were as follows. 1) On the wheat media containing 70%-water and $CaCo_{3}$, Aspergilus oryzae S.H.W. 131 is satisfactorily grown under the basic optimum conditions temperature $27^{\circ}C$- $30^{\circ}C$at relative humidity 100% for three days. 2) The enzyme solution extracted with water is successively purified through the passing on column of Asmti-177N for decolorization of it. And ion exchanger such as DEAAE Sphadex A-50 or Shepadex G-100 and fraction collector is necessary for the sepearte treatments of this enzyme. After washing it with organic solvents as aceton-EtOH, etc., it should be dried on the vacuum dryer at $40^{\circ}C$) The protease activity is determined by the amounts of amino acids, tyrosine. 4) The optimum pH of neutral protease is 6.0-8.0. 5) In effectively decomposing with this neutral protease, the optimum temperature is $35^{\circ}C$. 6) It is interesting that the amounts of metal ion affects the activity of neutral protease. For examples, if it were treated with manganic ion, its activity would be more effective than any other that.

• Journal of Korean Library and Information Science Society
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• v.10
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• pp.95-131
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• 1983

Index is a systematic guide to items contained in, or concepts derived from, a collection, Thus, it is represented as a paired set of index terms (t) and documents (D) : I= {(t,D) vertical bar t .mem. V, D .mem. W), where V is index vocabulary and W is document collection. Indexing is the process of analysing the informational content of records of knowledge and expressing the informational content in the language of the indexing system. It involves: 1) Selecting indexable concepts in a document; and 2) expressing these concepts in the language of the indexing system (as index entries): and an ordered list. Indexing process involves technical, semantic and syntactic problems. Technical problems are related to the accuracy of indexing, which is primarily governed by the indexer's ability of analysing subject, identifying indexable concepts, and coding. The proper levels of indexing exhaustivity, and index language specificity are also significant factors affecting the quality of index. Semantic problems are related to the choice of index terms and the form in which they should be used. Equivalent, hierarchical and affinitive/associative relationships of index terms are involved. Syntactic problems are largely related to the coordination of index terms. This process of coordination arises from the need to be able to search for the intersection of two or more classes defined by terms denoting distinct concepts. Finally, most valuable aspects of alphabetical subject indexing theories and practices are derived from those of Cutter, Kaiser, Ranganathan, Coates, Lynch and Austin, and discussed in details.

• Journal of Korean Library and Information Science Society
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• v.13
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• pp.131-166
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• 1986

This study is designed to review the methods of duplicate copies decision making in the academic library. In this thesis, I surveyed queueing & markov model, statistical model, and simulation model. The contents of the study can be summarized as follows: 1) Queueing and markov model is used for one of duplicate copies decision-making methods. This model was suggested by Leimkuler, Morse, and Chen, etc. Leimkuler proposed growth model, storage model, and availability model through using system analysis method. Queueing theory is a n.0, pplied to Leimkuler's availability model. Morse ad Chen a n.0, pplied queueing and markov model to their theory. They used queueing theory for measuring satisfaction level and Markov model for predicting user demand. 2) Another model of duplicate copies decision-making methods is statistical model. This model is suggested by Grant and Sohn, Jung Pyo. Grant suggested a model with a formula to satisfy the user demand more than 95%, Sohn, Jung Pyo suggested a model with two formulars: one for duplicate copies decision-making by using standard deviation and the other for duplicate copies predicting by using coefficient of variation. 3) Simulation model is used for one of duplicate copies decision-making methods. This model is suggested by Buckland and Arms. Buckland considered both loan period and duplicate copies simultaneously in his simulation model. Arms suggested computer-simulation model as one of duplicate copies decision-making methods. These methods can help improve the efficiency of collection development and solve some problems (space, staff, budget, etc, ) of Korean academic libraries today.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2000.11a
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• pp.131-142
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• 2000

Facility layout is the early stage of system design that requires a mid-term or long-term plan. Since improper facility layout might incur substantial logistics cost including material handling and re-installment costs, due consideration must be given to decisions on facility layout. Facility layout is concerned with low to arrange equipment necessary for production in a given space. Its objective is to minimize the sum of all the products of each equipment's amount of flow multiplied by distance. Facility layout also is related to the issue of NP-complete, i.e., calculated amounts exponentially increase with the increase of the number of equipment. This study discusses Hybrid GA developed, as an algorithm for facility layout, to solve the above-mentioned problems. The algorithm, which is designed to efficiently place equipment, automatically produces a horizontal passageway by the block, if a designer provides the width and length of the space to be handled. In addition, this study demonstrates the validity of the Algorithm by comparing with existing algorithms that have been developed. We present a Hybrid GA approach to the facility layout problem that improves on existing work in terms of solution quality and method. Experimental results show that the proposed algorithm is able to produce better solution quality and more practical layouts than the ones obtained by applying existing algorithms.

• Journal of the Korean Society of Industry Convergence
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• v.2 no.1
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• pp.131-137
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• 1999

It is very important that we try to keep our traditional historical assets in the original form for a long time. Artificial grotto has a very long and old history of about 1250 years in Korea. Yet, for the past several years there are many factors ruinning this historical treasure. Recently, specialist are new scientifically examining artificial grotto and evaluating its current condition. If you only judge these historical assets from the exterior structural environmental approach your scientific conclusion will not be complete. No one has studied artificial grotto from the viewpoint of indoor climate environmental. Therefore, I have surveyed and prepared a report of investigation as well as countermeasure so to understand the impact of indoor climate environmental on artificial grotto. The purpose of this paper is to first survey the existing research data based on exterior structural environment. Secondly, closely evaluate the new data of artificial grotto from the viewpoint of indoor environmental control by a natural climate phenomenon in Korea.

• The Korean Journal of Pain
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• v.3 no.2
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• pp.131-138
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• 1990

Postherpetic neuralgia (PHN) causes intractable pain which disturbs sleep and daily life. Numerous drugs and treatment strategies have been introduced for the management of PHN. However, no single regimen has proved to be effective. I analysed 38 patients with PHN. Amitriptyline, a tricyclic antidepressant and chlorpromazine were most commonly prescribed. Stellate ganglion blocks for the head and neck pain and epidural blocks for the rest part of the body were most frequently given. Triamcinolone acetate was administered epidurally in most of the cases or by iontophoresis on the affected skin area in two cases. Complications were related to the technique of the nerve block and the side effects of drugs administered. Repeated nerve blocks with tricyclic antidepressant and steroid therapy were thought to be the most effective for the treatment of postherpetic pain.