• Toxicological Research
• /
• v.27 no.1
• /
• pp.19-23
• /
• 2011

It has been proposed that acute phase response can be a mechanism by which inhaled particles exert adverse effects on the cardiovascular system. Although some of the human acute phase proteins have been widely studied as biomarkers of systemic inflammation or cardiovascular diseases, there are only a few studies that investigated the role of serum amyloid P (SAP), a major acute phase protein in mice. In this study, we investigated the changes in SAP, following inhalation exposure to nickel hydroxide nanoparticles (nano-NH). We conducted 1) acute (4 h) exposure to nano-NH at 100, 500, and $1000\;{\mu}g/m^3$ and 2) sub-acute (4h/d for 3d) exposure at $1000\;{\mu}g/m^3$, then measured serum SAP protein levels along with hepatic Sap mRNA levels. The results show that inhaled nano-NH can induce systemic acute phase response indicated by increased serum SAP levels and hepatic Sap mRNA levels. To the best of our knowledge, this is the first study showing induction of SAP in response to repeated particle exposure, and the results suggest that SAP can be used as a biomarker for systemic inflammation induced by inhaled particles.

• Proceedings of the KIEE Conference
• /
• 1996.07a
• /
• pp.31-33
• /
• 1996

A SRM develops its torque according to the inductance variation as the rotor position and the phase current. The variation of the inductance and the phase current plays an important role in output characteristics. Predicting and calculating the inductance is invaluable in the study of SRM. This paper suggests the estimation method of inductance as variation of phase current and rotor position considering magnetic saturation of motor core. This method is also applied to full-pitched winding SRM.

• Macromolecular Research
• /
• v.15 no.1
• /
• pp.39-43
• /
• 2007

The amphiphilic block copolymer (PEtOz-PCL) of poly(2-ethyl-2-oxazoline) (PEtOz) and poly(${\varepsilon}$-caprolactone) (PCL) formed spherical micellar structures with an average diameter of 26 nm in aqueous phase. Au and Pd nanoparticles with an average diameter of $2{\sim}3nm$ were prepared by using the PEtOz-PCL micelle consisting of a PEtOz shell and PCL core. The Au nanoparticles of PEtOz-PCL micelles in aqueous phase could be transferred into organic phase by using n-dodecanethiol. The use of the Pd-NP/PEtOz-PCL micelle as a nanoreactor for Suzuki cross-coupling reaction was investigated.

• Proceedings of the KIEE Conference
• /
• 2011.07a
• /
• pp.788-789
• /
• 2011

A comprehensive thermo-electromagnetic model has been developed to estimate temperature and electromagnetic distribution in an three-phase induction motor under steady state operation. Electromagnetic modeling enables us to predict thermal dissipation rates by eddy-current loss and copper loss in induction motors. Non-uniform temperature distributions are investigated to account for the strong effect of local temperature build-up on the motor performance and expected life-span. For more accurate thermal modeling purpose, Heat loss mapping method, which is matched up with electromagnetic losses and volumetric heat source, is developed and performed analysis. Heat loss mapping method can be greatly used as a design or diagnostic tool for three-phase induction motors with complex structural electromagnetic fields.

• Industrial Engineering and Management Systems
• /
• v.10 no.1
• /
• pp.15-23
• /
• 2011

This research considers scheduling problems with jobs which can be divided into sub-jobs and do not required to be processed immediately following one another. Heuristic algorithms considering how to divide jobs are proposed in an attempt to find near-optimal solutions within reasonable run time. The algorithms contain two phases which are executed recursively. Phase 1 of the algorithm determines how jobs should be divided while phase 2 solves the scheduling problem given the sub-jobs established in phase 1. Simulated annealing and genetic algorithms are applied for the two phases and four heuristic algorithms are established. Numerical experiment is conducted to determine the best parameter values for the heuristic algorithms. Examples with different sizes and levels of complexity are generated. Performance of the proposed algorithms is evaluated. It is shown that the proposed algorithms are able to efficiently and effectively solve the considered problems.

• 한국전산유체공학회:학술대회논문집
• /
• 2008.03a
• /
• pp.171-175
• /
• 2008

In the present study, a numerical simulations are investigated in a stirred solid/liquid system by using Eulerian multi-phase model. The transient flow field of liquid phase and distribution of solid particles are predicted in stirred tanks consisting of 4-pitched paddles impeller and baffles. The effects of number and width of baffles on the mixing time and the quality of solid suspension in a stirred tank are presented numerically. The result shows that the mixing time decreases as the width and number of baffles increase.

• Proceedings of the KIEE Conference
• /
• 2007.04a
• /
• pp.246-248
• /
• 2007

This paper presents fast locking PLL(Phase Locked Loop) that can improve a jitter noise characteristics and acquisition process by designing a PFD(Phase Frequency Detector) circuit. The conventional PFD has not only a jitter noise caused from such a demerit of the wide dead zone and duty cycle, but also a long delay interval that makes a high speed operation unable. The advanced PFD circuit using the TSPC(True Single Phase Clocking) circuit is proposed, and it has excellent performances such as 1.75us of locking time and independent duty cycle characteristic. It is fabricated in a 0.018-${\mu}m$ CMOS process, and 1.8v supply voltage, and 25MHz of input oscillator frequency, and 800MHz of output frequency and is simulated by using ADE of Cadence.

• 한국전산유체공학회:학술대회논문집
• /
• 2008.03b
• /
• pp.236-239
• /
• 2008

In the present study, a transient glass particle distribution in a stirred solid/liquid mixer was investigated using computational fluid dynamics(CFD). The flow patterns and solid concentaration distriburion in a solid/liquid mixer formed by pitched paddle and baffles were predicted. The numerical results were compared to experimental data from the available literature. Eulerian multi-phase model was used to investigate the influence of the density of solid particle on the same impeller speed. A good agreement was obtained between the experimental data and simulation results.

• Archives of Pharmacal Research
• /
• v.28 no.2
• /
• pp.243-248
• /
• 2005

To improve the skin permeability of piroxicam, a new oil-in-water microemulsion containing $0.5\%$ piroxicam was developed. Among various oils investigated for their suitability as an oil phase for the microemulsion system, oleic acid showed both excellent solubility and skin permeation enhancing effect for piroxicam. Microemulsion existence ranges were identified through the construction of the pseudo-ternary phase diagram. The effect of the content of oleic acid and the ratio of the surfactant/cosurfactant on skin permeation of piroxicam were evaluated with excised rat skins. The optimum formulation with the highest skin permeation rate ($47.14\;{\mu}g/cm^2/h$) consisted of $0.5\%$ piroxicam, $10\%$ oleic acid, $60\%$ Labrasol/ethanol (1:5) and water.

• Journal of IKEEE
• /
• v.14 no.2
• /
• pp.69-75
• /
• 2010

A 3D graphics pipeline is largely divided into geometry stage and rendering stage. In this paper, we propose a method that accelerates a geometry processing in multi-core GP-GPU, using dual-phase structure. It can be improved by parallel data processing using SIMD of GP-GPU, dual-phase structure and memory prefetch. The proposed architecture improves approximately 19% of performance when it use all the features.