• 대한상한금궤의학회지
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• v.9 no.1
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• pp.115-123
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• 2017

Objective : The purpose of this paper is to report the improvement of patient with Chronic Fatigue Syndrome(CFS) treated by herb medication based on Shanghanlun disease pattern identification diagnostic system. Methods : According to 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions', the patient was diagnosed with Eumyangyeokchahunobok-byung, number 393 provision, and took Jisilchija-tang herb medication for 75days. The changing symptom of chronic fatigue syndrome was estimated by QOL-CFS(Chalder Fatigue Scale) and VAS(Visual Analogue Scale). Results : The QOL-CFS changed 21 to 8 and VAS changed 10 to 1. Conclusions : It is existing theory that Eumyangyeokchahunobok-byung is caused by 'having too much sex relation'. But the author diagnosed Eumyangyeokchahunobok-byung as 'Symptoms worsen when awaken at night, and sleep at day caused by poor sleep pattern' according to the palaeography about shanghanlun, and got a good results.

• 대한상한금궤의학회지
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• v.9 no.1
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• pp.1-20
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• 2017

Objective : This study is to propose a new hypothesis about the interpretation of Jueyinbing in Shanghanlun by studying 2 Jueyinbing cases. Methods : We analyzed the original form of the chinese characters 'Jue(厥)', 'Jueyin(厥陰)' and 'Huoluan(?亂)' and tried to understand their contexts in Shanghanlun. At the same time, we analyzed 2 clinical cases diagnosed and treated as Jueyinbing according to newly hypothesized definition. Results : Both patients suffered from eye diseases which caused by concentrating on a sophisticated work by straining their hands, feet and chest during the night time. After the herbal intervention, their eye diseases are improved firstly. The National Eye Institute 25-item Visual Function Questionnaire (NEI-VFQ) score increased on both patients. Not only all the patients' chief complaints relieved but their other clinical problems such as limb pain, hand tremble also improved. Conclusions : These results highly insist that, at least in 15 characters provision of Shanghanlun, Jueyinbing had had the different usage from the conventional terminology, and it is assumed that Jueyinbing means the disease made by concentrating on a sophisticated work by straining hands, feet and chest during night time.

• 대한상한금궤의학회지
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• v.12 no.1
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• pp.49-60
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• 2020

Objective: To explore the meaning of 虛in Shanghanlun through two cases. Methods: We analyzed the original form of 虛and the contexts in Shanghanlun. Concurrently, we report two clinical cases treated with Chijasi-tang according to the newly deduced definition of 虛. Results: 虛is composed of 丘and 虍, which means a tiger on a large hill. Here, the meaning of "empty"was derived. In both cases, sleep disorders and heart stuffiness were the chief complaints, which were confirmed to occur under 虛's circumstances. Therefore, Chijasi-tang was administered to two patients with a feeling of emptiness as a pathogenic factor, and improvements were confirmed in both cases. Conclusions: In 15 provisions of Shanghanlun, 虛is defined as "a feeling of emptiness"instead of of "deficient,"which was widely used previously, and appears clinically as "emptiness after being hurt by someone."This definition was applicable in both cases.Further study of the other characters is needed because the previously used meaning may be different in the 15-character provisions of the Shanghanlun.

• 대한상한금궤의학회지
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• v.15 no.1
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• pp.1-52
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• 2023

Objective : The objective of this study was to explore the meaning of Mai (脉) in the fifteen letters provisions of Gangpyeong-Shanghanlun through the comparative analysis of 10 cases and paleography. Methods : We have collected 10 cases that have been diagnosed and treated by Gangpyeong-Shanghanlun Mai (脉) provision. And then, comparative analysis has been done among those 10 cases. Based on result of case analysis, paleographic meaning of each Mai (脉) have been studied to redefine Gangpyeong-Shanghanlun Mai (脉)'s meaning. Results : After administration of Mai (脉) provision's herbal medicine, all 10 patients recovered their mobility problem and pain. From this result, we could fomulate the hypothesis that Mai (脉) in Gangpyeong-Shanghanlun could mean mobility problems. After through further paleography studies, we could elaborate each Mai (脉)'s clinical meaning and related diseases. Conclusions : Mai (脉) in Gangpyeong-Shanghanlun could mean mobility problems caused by various diseases, which include musculoskeletal pain, neuropathy, syncope, fatigue, developmental disability and major depressive disorder.

• Journal of Korean Medical classics
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• v.31 no.3
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• pp.77-97
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• 2018

Objectives : Qianjinyifang Shanghan is an important versions of Shanghanlun, but it was never introduced widely, and studies on its were not done a lot. Thus, the author seeks to study this book in order to find its special features, its relationship with other versions of Shanghanlun, and its status in the process of the transmission of Shanghanlun. Methods : Dissertations on Qianjinyifang Shanghan and dissertations that compare Yuhanben and Songben were studied. Sentences were numbered based on Qianjinyifang Shanghan, Tangbenshanghanlunjiaozhu to compare with other versions of Shanghanlun. Results : Sunsimiao brought the changes of "以法方類證, 方證同條 比類相附" in Shanghanlun. It organized Taiyangbing chapters according to their decoction pattern, and made Taiyangbing chapter name as "太陽病用${\cdots}$湯法". Chì shi ye was placed in front of Taiyangbìngyongguizhitangfa. Jueyinbing and Liouhuibing were combined to one that were seperated in Yuhanben. Shanghanyiji titlel was put in front of Yijipian to distinguish clearly from Sanyinsanyangpian. Sanyinsanyangpian and Yijipian contains many sentences that are missing in Songben. Conclusions : Qianjinyifang Shanghan is one of the major Shanghanluns that were saved by Jiaozhengyishuju I Northern Song Period, and it was put together as an independent book after the Ming and Qing dynasties. It plays an important role in the process of the transmission of Shanghanlun in 800 years, through 3C, 7C, and 11C. Moreover, when we compare the three books of Qianjinyifang Shanghan, Yuhanben, and Songben's Sanyinsanyangpian and Yijipian's sentences, we could know that they began from a common original text, but they became branched, and Qianjinyifang Shanghan has a closer relationship with Yuhanben. Sanyinsanyangpian and Yijipian sentences can serve to supplement what is missing in today's Songben.

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.4
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• pp.159-169
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• 2020

Shanghanlun (Treatise on Cold Damage Diseases) is the oldest document in the literature on clinical records of Traditional Asian medicine (TAM), on which TAM theories about symptoms-herbs relationships are based. In this study, we aim to quantitatively explore the relationships between symptoms and herbs in Shanghanlun. The text in Shanghanlun was converted into structured data. Using the structured data, Term Frequency - Inverse Document Frequency (TF-IDF) scores of symptoms and herbs were calculated from each chapter to derive the major symptoms and herbs in each chapter. To understand the structure of the entire document, principal component analysis (PCA) was performed for the 6-dimensional chapter space. Bipartite network analysis was conducted focusing on Jaccard scores between symptoms and herbs and eigenvector centralities of nodes. TF-IDF scores showed the characteristics of each chapter through major symptoms and herbs. Principal components drawn by PCA suggested the entire structure of Shanghanlun. The network analysis revealed a 'multi herbs - multi symptoms' relationship. Common symptoms and herbs were drawn from high eigenvector centralities of their nodes, while specific symptoms and herbs were drawn from low centralities. Symptoms expected to be treated by herbs were derived, respectively. Using measurable metrics, we conducted a computational study on patterns of Shanghanlun. Quantitative researches on TAM theories will contribute to improving the clarity of TAM theories.

• 대한상한금궤의학회지
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• v.7 no.1
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• pp.29-43
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• 2015

Objective : The purpose of this paper is to report the improvement of 3 patients with uterine fibroid treated by herb medication based on Shanghanlun disease pattern identification diagnostic system. Methods : According to 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions', they were diagnosed with Taeyang-byung, Yangmyung-byung. They took different herb medications more than 8 weeks according to their diagnosis. The size of uterine fibroid was estimated by ultrasonography. Results : The size of uterine fibroid reduced from 3.94cm to 2.55cm on first patient, 5.20cm to 4.86cm on second patient, 12.63cm to 7.77cm on third patient. Conclusions : Herb medication not only reduced the size of uterine fibroid but also improved symptoms such as dysmenorrhea, vaginal bleeding, pelvic discomfort, fatigue. In addition, this is the first case report treating the uterine fibroid with herb medication of shanghanlun in Korea.

• 대한상한금궤의학회지
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• v.8 no.1
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• pp.1-23
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• 2016

Objectives : The purpose of this paper is to find out the safe dose and clinical use for administration of Glycyrrhizae Radix in Shanghanlun(傷寒論). Methods : Web-databases(OASIS, NDSL, Pubmed, Google) were searched with keywords including 'Licorice', 'Pseudoaldosteronism', 'Glycyrrhizin', 'Testosterone' on 14/10/2016. The searched about 40 papers and books were reveiwed. Results : Glycyrrhizin(GL) and 3-monoglucuronyl glycyrrhetinic acid(3MGA) in Glycyrrhizae Radix are found to be the main compounds vulnerable for inducing pseudoaldosteronism. The dose range of Glycyrrhizae Radix in Shanghanlun prescriptions is from 0.25 g to 12 g as a daily administration, and this dose satisfies the guidelines of WHO, European Union, ABC etc. And risk factors contributing for personal sensitivities are old age(>60), female sex, liver dysfunction, hypokalemia, prolonged gastrointestinal transit time, anorexia nervosa, decreased 11-${\ss}$-hydroxysteroid dehydrogenase-2 activity and hypertension. Conclusions : As a result, dose of Glycyrrhizae Radix in Shanghanlun(傷寒論) is safe. However, the personal sensitivity and unexpected drug interactions are independent from doses of GL, so doctors should monitor those risk factors and symptoms of pseudoaldosteronism when administering Glycyrrhizae Radix.

• 대한상한금궤의학회지
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• v.8 no.1
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• pp.53-65
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• 2016

Objective : The purpose of this paper is to report the improved contact dermatitis(CD) treated with the herbal medication based on Shanghanlun disease pattern identification diagnostic system. The level V steroid ointments were no use to the patient 3weeks before the treatment. Methods : In this case, the patient was diagnosed according to 'Disease Pattern Identification Diagnostic System based on Shanghanlun Provisions' and took Mahwang-tang for 36days since the final diagnosis was Taeyang-byung, number 46 provision. The photographs of patient's hands were taken to observe the process of the skin status and the discomfort from CD was measured with DLQI(Dermatologic Life Quality Index) and NRS(Numeric Rating Scale). Results : The DLQI score changed from 24 to 7 and NRS of itching changed form 8 to under 4. Conclusions : This case report shows that the herbal medication through the diagnostic system could be a remedy on CD, dealing with the skin status with no use of the level V steroid ointments. It is needed proving an alternative possibility of Korean Medicine, on other skin diseases, with later studies since there are many reports on the side-effects after some long-term steroid treatments.

• 대한상한금궤의학회지
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• v.11 no.1
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• pp.113-123
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• 2019

Objective : The purpose of this study was to report the improvement in two patients with different complaints of sleep disorder treated with herbal medication based on the Shanghanlun disease pattern identification diagnostic system (DPIDS), and hypothesize the meaning of word '更'. Methods : According to DPIDS, patients were diagnosed with Taeyang-byung no. 29 provision, and took Gamchogungang-tang herb medication 15 or 90days. The results of administration were evaluated by the hyperhidrosis disease severity scale (HDSS) and the visual analog scale (VAS). Results : After administration of Gamchogungang-tang 15 or 90days, based on 29 provision of Gamchogungang-tang diagnosed according to Shanghanlun provisions, in one case the HDSS decreased from 3 to 1 and the VAS decreased from 10 to 1. In the other case, the VAS decreased from 10 to 1. Conclusions : Each patient not only recovered from symptoms of hyperhidrosis and alopecia areata, but also from sleep disorders following administration of a single medication of Gamchogungang-tang. This case report suggests that the word '更' in the 29 provisions of Shanghanlun means sleep disorder in this case.