In-situ leaching could be one of the promising mining methods to extract the minerals from deep fractured rock mass. Constrained by the low permeability at depth, however, the performance does not meet the expectation. In fact, the rock mass permeability mainly depends on the pre-existing natural fractures and therefore play a crucial role in in-situ leaching performance. More importantly, fractures have various characteristics, such as aperture, persistence, and density, which have diverse contributions to the promising method. Hence, it is necessary to study the variation of fluid rate versus fracture parameters to enhance in-situ leaching performance. Firstly, the subsurface fractures from the depth of 1500m to 2500m were mapped using the discrete fracture network (DFN) in this paper, and then the numerical model was calibrated at a particular case. On this basis, the fluid flow through fractured rock mass with various fracture characteristics was analyzed. The simulation results showed that with the increase of Fisher' K value, which determine the fracture orientation, the flow rate firstly decreased and then increased. Subsequently, as another critical factor affecting the fluid flow in natural fractures, the fracture transmissivity has a direct relationship with the flow rate. Sensitive study shows that natural fracture characteristics play a critical role in in-situ leaching performance.