Under the circumstances of China's slower economic growth, the first document ofthe central committee of the CPC continue to focus on "three agricultures" problems, agriculture play a basic role on China's economic. Since 2007, the first document directly stresses the important role of agricultural and fisheries every year. Central Government Working Report of 2015 also stresses that under the new normal of economy, it is important to improve quality and efficiency of agriculture. Agricultural focus going forward will be on improving capacity of competitiveness, innovation and sustainable development.The fishery as an important part of agriculture plays a vital role in the protection of national food security, the prosperity of the rural economy and the optimization of national food structure. However, the situation faced on accelerating the speed of Chinese fisheries is still grim. As an important fishery breeding city in my country, Weihai has achieved remarkable results in the development of fisheries. Based on the input-output indicators of Weihai City from 2010 to 2020, this article uses the DEA model method to conduct a comprehensive analysis of the factors affecting the fishery production efficiency in Weihai City. This paper calculates the two stages of comprehensive efficiency, pure technical efficiency and scale efficiency, and comprehensive compares the two stages. The research results show that: From 2010 to 2020, the average comprehensive technical efficiency of Weihai fishery was 0.928, the average scale efficiency was 0.963, and the average pure technical efficiency was 0.963. The comprehensive technical efficiency of Weihai fishery production showed an upward and downward trend, the pure technical efficiency showed a downward and then upward trend, and the pure technical efficiency showed a fluctuating trend.