In the present study, numerical unsteady simulations of the NREL Phase VI wind turbine in downwind operation conditions were conducted to investigate rotor-tower interaction. The calculations were performed using an unstructured mesh, incompressible Reynolds-averaged Navier-Stokes flow solver. To capture the unsteady effects associated with the tower shadow between the rotor blades and the tower, the wind turbine was modelled including the rotor, tower, hub, and nacelle. The present results generally showed good agreements with available experimental data. At the lowest wind speed, the pressure distribution was characterized by a complete collapse of the suction peak on the blade when the blade passes through the tower wake. It was found that unsteady effects play a significant role in the response of the blades.