Purpose : This study was intended to investigate the structural relationship among empowerment, self-efficacy, job motivation, autonomy, critical thinking, job-satisfaction, burnout, and self-achievement. In addition, we tested the moderating effect of the career period on the influence of empowerment. Methodology : The structural equation model was used to test the causal relationship between factors, and t-test, ANOVA, descriptive statistics are applied to analyze the research data. Findings : The result of this study shows that the structural model that is the empowerment encourages the self-efficacy, job motivation, autonomy, and critical thinking, also these factors affect the self-achievement through both the job-satisfaction and burnout is acceptable according to the goodness of fitness indices. In addition, we show that the career period moderates the influence of empowerment on the self-efficacy, job-motivation, and autonomy, but not critical thinking. Usually, the shorter the career period is the higher the influence of empowerment is. This moderating effect means that to give proper empowerment to lower position nurses encourage them, and prevent from burnout. Therefore, they feel job-satisfaction and finally self-achievement. Practical Implications : The empowerment helps the nurse to activate self-efficacy, job motivation, autonomy, critical thinking. Hence, these factors decrease burn-out but increase job satisfaction. Finally a sense of self-perfection increase.