Clinical and Experimental Vaccine Research

  • 제13권3호
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  • Pages.225-231
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  • 2024
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  • 2287-3651(pISSN)
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  • 2287-366X(eISSN)
대한백신학회 (The Korean Vaccine Society)
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SARS-CoV-2 parental vaccination and risk of multisystem inflammatory syndrome in children: a single-center retrospective study

  • Raffaele Falsaperla (Neonatal Intensive Care Unit, San Marco Hospital, University Hospital Policlinico) ;
  • Vincenzo Sortino (Unit of Pediatrics and Pediatric Emergency, University Hospital Policlinico) ;
  • Ausilia Desiree Collotta (Unit of Pediatrics and Pediatric Emergency, University Hospital Policlinico) ;
  • Patrizia Grassi (Microbiology Section, Analysis Laboratory, San Marco Hospital) ;
  • Marco Simone Vaccalluzzo (Department of General Surgery and Medical Surgical Specialties, Section of Orthopaedics, A.O.U. Policlinico Rodolico-San Marco, University of Catania) ;
  • Alfredo Pulvirenti (Bioinformatics Unit, Department of Clinical and Experimental Medicine, University of Catania) ;
  • Francesco Gambilonghi (Postgraduate Training Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania) ;
  • Martino Ruggieri (Unit of Clinical Pediatrics, AOU "Policlinico", PO "G. Rodolico", University of Catania)
  • 투고 : 2024.01.22
  • 심사 : 2024.06.26
  • 발행 : 2024.07.31
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초록

Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) usually causes a mild disease in children and the most serious consequence is multisystem inflammatory syndrome in children (MIS-C). Currently, there are no data about the protective role of vaccination performed by parents on children regarding the development of MIS-C. The aim of our study is to establish whether parental vaccination is related to MIS-C and the protective value of SARS-CoV-2 vaccination performed by parents against the occurrence of MIS-C in their children. Materials and Methods: Our retrospective single center study included 124 patients aged 1 month to 18 years admitted to emergency department from April 2020 to March 2022 for coronavirus disease 2019 disease. Results: Parental vaccination was negatively correlated with the development of MIS-C: 4% of patients with both parents vaccinated developed MIS-C, while patients with no parent vaccinated to have developed MIS-C were 20%. Conclusion: Parental vaccination could be an important factor influencing the course of the disease and reduces the probability that a child would develop MIS-C by 83% if both parents vaccinated.

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참고문헌

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