Clinical and Experimental Vaccine Research

  • 제13권3호
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  • Pages.218-224
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  • 2024
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  • 2287-3651(pISSN)
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  • 2287-366X(eISSN)
대한백신학회 (The Korean Vaccine Society)
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Incidence of narcolepsy symptoms after taking COVID-19 vaccines: a Jordanian cross-sectional study

  • Mohammad Al Katatbeh (Department of Special Surgery, Faculty of Medicine, Hashemite University) ;
  • Yazan Al-Mashakbeh (Department of Ear Throat Nose, New Zarqa Governmental Hospital) ;
  • Hadeel Freihat (Faculty of Medicine, Jordan University of Science & Technology) ;
  • Hiba Gharam (Faculty of Medicine, Jordan University of Science & Technology) ;
  • Rahmeh Mohammad (Faculty of Medicine, Jordan University of Science & Technology) ;
  • Rahma Aldalki (Faculty of Medicine, Jordan University of Science & Technology) ;
  • Sadeen Eid (Faculty of Medicine, Jordan University of Science & Technology) ;
  • Reema Sharman (Department of Obstetrics and Gynecology, Princess Badea Teaching Hospital) ;
  • Nizar Heissat (Department of Anesthesia, Al Hussain New Salt Hospital) ;
  • Ghusoon Al-Samarraie (Department of General Surgery, Jordan Hospital) ;
  • Ahmad Al-Shaibie (Department of Emergency Medicine, Bashir Hospital) ;
  • Laith Khasawneh (Department of Special Surgery, Faculty of Medicine, Hashemite University)
  • 투고 : 2024.01.15
  • 심사 : 2024.06.26
  • 발행 : 2024.07.31
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초록

Purpose: Sleeping disorders were reported in many patients who took vaccines during previous pandemics. We aim to investigate the relationship between coronavirus disease 2019 (COVID-19) vaccines and the incidence of narcolepsy symptoms in the Jordanian population. Materials and Methods: We used a descriptive, cross-sectional, online self-administered survey conducted between December 2022 and May 2023. The survey targeted males and females above the age of 18 years who took any type of COVID-19 vaccine, had no chronic diseases, and had no sleep disorders prior to taking the vaccine. The survey was distributed via social media platforms. Results: A total of 873 participants were included in this study, consisting of 44.4% males and 55.6% females, with the majority being in the 18-29 age group. Most participants (79.8%) received two vaccine doses, with the Pfizer vaccine being the most common. Nearly half of the participants reported excessive daytime sleepiness. Sleep paralysis and hypnagogic hallucinations were reported by a notable proportion of participants, but no significant differences were found among the vaccine types. Sleep attacks and fragmented nighttime sleep were associated with the number of vaccine doses received, suggesting a possible influence of the dose count on these symptoms. The presence of excessive daytime sleepiness, sudden loss of muscle tone, sleep paralysis, and hypnagogic hallucinations showed no significant association with the number of doses taken. Conclusion: We hypothesize a possible link between COVID-19 vaccination and the emergence of narcolepsy symptoms in Jordanian individuals. Additional investigations and continuous monitoring to determine the extent of the risk and uncover potential mechanisms behind this connection should be performed.

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참고문헌

  1. Coronavirus&COVID-19 overview: symptoms,risks, prevention, treatment & more [Internet]. New York (NY): Webmd; c2024 [cited 2024 Jan 8]. Available from: https://www.webmd.com/covid/coronavirus 
  2. COVID-19: epidemiology, virology, and prevention [Internet]. Waltham (MA): UpToDate; 2024 [cited 2024 Jan 8]. Available from: https://www.uptodate.com/contents/covid-19-epidemiology-virology-and-prevention 
  3. COVID-19 Data Explorer [Internet]. Oxford: Our World in Data; 2024 [cited 2024 Jan 8]. Available from: https://ourworldindata.org/explorers/coronavirus-data-explorer 
  4. Vaccines and Related Biological Products Advisory Committee December 10, 2020 Meeting Briefing Document-FDA[Internet]. Silver Spring (MD): Food and Drug Administration; 2020 [cited 2024 Jan 8]. Available from: https://www.fda.gov/media/144245 
  5. NassarRI,Alnatour D, Thiab S, NassarA, El-Hajji F,Basheti IA. Short-term side effects of COVID-19 vaccines: a cross-sectional study in Jordan. Hum Vaccin Immunother 2022;18:2082792. 
  6. Medeiros KS, Costa AP, Sarmento AC, Freitas CL, Goncalves AK. Side effects of COVID-19 vaccines: a systematic review and meta-analysis protocol of randomised trials. BMJ Open 2022;12:e050278. 
  7. Ferguson D, Wrigley S, Purcell E, et al. Single center analysis of patients with H1N1 vaccine-related narcolepsy and sporadic narcolepsy presenting over the same time period. J Clin Sleep Med 2021;17:885-95.  https://doi.org/10.5664/jcsm.9052
  8. Watson OJ, Barnsley G, ToorJ, HoganAB, Winskill P, Ghani AC. Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infect Dis 2022;22:1293-302.  https://doi.org/10.1016/S1473-3099(22)00320-6
  9. Selected adverse events reported after COVID-19 vaccination [Internet]. Atlanta (GA): Centers for Disease Control and Prevention; 2023 [cited 2024 Jan 8]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/adverse-events.html 
  10. El-Shitany NA, Harakeh S, Badr-Eldin SM, et al. Minor to moderate side effects of Pfizer-BioNTech COVID-19 vaccine among Saudi residents: a retrospective cross-sectional study.Int J Gen Med 2021;14:1389-401.  https://doi.org/10.2147/IJGM.S310497
  11. Mulligan MJ, Lyke KE, Kitchin N, et al. Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults. Nature 2020;586:589-93.  https://doi.org/10.1038/s41586-020-2639-4
  12. Mansukhani MP, Kolla BP, Ramar K. International classification of sleep disorders 2 and American Academy of Sleep Medicine practice parameters for central sleep apnea. Sleep MedClin2014;9:1-11. 
  13. Bassetti CL, Adamantidis A, Burdakov D, et al. Narcolepsy: clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol 2019;15:519-39. 
  14. Sarkanen TO, Alakuijala AP, Dauvilliers YA, Partinen MM. Incidence of narcolepsy after H1N1 influenza and vaccinations: systematic review and meta-analysis. Sleep Med Rev 2018;38:177-86.  https://doi.org/10.1016/j.smrv.2017.06.006
  15. Nohynek H, Jokinen J, Partinen M, et al. AS03 adjuvanted AH1N1 vaccine associated with an abrupt increase in the incidence of childhood narcolepsy in Finland. PLoS One 2012;7:e33536. 
  16. Miller E, Andrews N, Stellitano L, et al. Risk of narcolepsy in children and young people receiving AS03 adjuvanted pandemic A/H1N1 2009 influenza vaccine: retrospective analysis. BMJ 2013;346:f794. 
  17. Ahmed SS, Volkmuth W, Duca J, et al. Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2. Sci Transl Med 2015;7:294ra105. 
  18. Garrido-Suarez BB, Garrido-Valdes M, Garrido G. Reactogenic sleepiness after COVID-19 vaccination: a hypothesis involving orexinergic system linked to inflammatory signals. Sleep Med 2022;98:79-86.  https://doi.org/10.1016/j.sleep.2022.06.011
  19. Kelley KW, Kent S. The legacy of sickness behaviors. Front Psychiatry 2020;11:607269. 
  20. Irwin MR, Opp MR. Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology 2017;42:129-55.  https://doi.org/10.1038/npp.2016.148
  21. Besedovsky L, Lange T, Haack M. The sleep-immune crosstalk in health and disease. Physiol Rev 2019;99:1325-80.  https://doi.org/10.1152/physrev.00010.2018
  22. Chieffi S, Carotenuto M, Monda V, et al. Orexin system: the key for a healthy life. Front Physiol 2017;8:357. 
  23. Di Pasquale A, Bonanni P, Garcon N, Stanberry LR, El-Hodhod M, Tavares Da Silva F. Vaccine safety evaluation: practical aspects in assessing benefits and risks. Vaccine 2016;34:6672-80.  https://doi.org/10.1016/j.vaccine.2016.10.039
  24. Lange T, Dimitrov S, Bollinger T, Diekelmann S, Born J. Sleep after vaccination boosts immunological memory. J Immunol 2011;187:283-90.  https://doi.org/10.4049/jimmunol.1100015
  25. Sleep deprivation and deficiency: what are sleep deprivation and deficiency? [Internet]. Bethesda (MD): National Heart, Lung, and Blood Institute; 2022 [cited 2024 Jan 8]. Available from: https://www.nhlbi.nih.gov/health/sleep-deprivation 
  26. Borobia AM, Carcas AJ, Perez-Olmeda M, et al. Immunogenicity andreactogenicityofBNT162b2boosterinChAdOx1-S-primed participants (CombiVacS): a multicentre, openlabel, randomised, controlled, phase 2 trial. Lancet 2021;398:121-30.  https://doi.org/10.1016/S0140-6736(21)01420-3
  27. Toledo-Romani ME, Garcia-Carmenate M, Verdecia-Sanchez L, et al. Safety and immunogenicity of anti-SARS-CoV-2 heterologous scheme with SOBERANA 02 and SOBERANA Plus vaccines: phase IIb clinical trial in adults. Med 2022;3:760-73.  https://doi.org/10.1016/j.medj.2022.08.001
  28. Hernandez-Bernal F, Ricardo-Cobas MC, Martin-Bauta Y, et al. Safety, tolerability, and immunogenicity of a SARS-CoV-2 recombinant spike RBD protein vaccine: a randomised, double-blind, placebo-controlled, phase 1-2 clinical trial(ABDALA Study). EClinicalMedicine 2022;46:101383. 
  29. Yamamoto S, Fukunaga A, Tanaka A, et al. Association between reactogenicity and SARS-CoV-2 antibodies after the second dose of the BNT162b2 COVID-19 vaccine. Vaccine 2022;40:1924-7. https://doi.org/10.1016/j.vaccine.2022.02.052