Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Host modulation therapy for improving the osseointegration of dental implants under bone healing-suppressed conditions: a preclinical rodent-model experiment

  • Young Woo Song (Department of Periodontology, Gangnam Severance Hospital, Yonsei University College of Dentistry) ;
  • Jin-Young Park (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Yoon-Hee Kwon (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry) ;
  • Wooyoung Eric Jang (Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry) ;
  • Sung-Jin Kim (Department of Oral Histology and Developmental Biology, School of Dentistry and Dental Research Institute, Seoul National University) ;
  • Jeong Taeg Seo (Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry) ;
  • Seok Jun Moon (Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry) ;
  • Ui-Won Jung (Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry)
  • Received : 2023.03.23
  • Accepted : 2023.07.26
  • Published : 2024.06.30
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Abstract

Purpose: Placing dental implants in areas with low bone density or in conditions where bone healing is suppressed is challenging for clinicians. An experiment using a rodent model was performed with the aim of determining the efficacy of host modulation by increasing the systemic level of cholesterol sulfate (CS) using Irosustat in the context of the bone healing process around dental implants. Methods: In 16 ovariectomised female Sprague-Dawley rats, 2 implant fixtures were placed in the tibial bones (1 fixture on each side). At 1 week after surgery, the high-CS group (n=8) received Irosustat-mixed feed, while the control group (n=8) was fed conventionally. Block specimens were obtained at 5 weeks post-surgery for histologic analysis and the data were evaluated statistically (P<0.05). Results: Unlike the high-CS group, half of the specimens in the control group demonstrated severe bone resorption along with a periosteal reaction in the cortex. The mean percentages of bone-to-implant contact (21.5%) and bone density (28.1%) near the implant surface were significantly higher in the high-CS group than in the control group (P<0.05), as was the number of Haversian canals (by 5.3). Conclusions: Host modulation by increasing the CS level may enhance the osseointegration of dental implants placed under conditions of impaired bone healing.

Keywords

Acknowledgement

This study was supported by the Yonsei University College of Dentistry Fund (6-2022-0012).

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