DOI QR코드

DOI QR Code

Biosafety Risk Control Strategies in Laboratory Animal Research

  • Shun-tai Weng (Fujian Center for Disease Control and Prevention (Fujian Provincial Key Laboratory of Zoonosis Research)) ;
  • Qu-wen Li (Fujian Center for Disease Control and Prevention (Fujian Provincial Key Laboratory of Zoonosis Research)) ;
  • Ya-dong Gao (Fujian Center for Disease Control and Prevention (Fujian Provincial Key Laboratory of Zoonosis Research)) ;
  • Yu-feng Qiu (Fujian Center for Disease Control and Prevention (Fujian Provincial Key Laboratory of Zoonosis Research))
  • Received : 2023.05.31
  • Accepted : 2023.11.08
  • Published : 2024.03.30

Abstract

To understand biosafety's current situation in laboratory animal research and risk factors affecting occupational health. Compliance surveys were conducted by questionnaire via Questionnaire Star (an application app on the Internet) in Chinese. Thirty-nine anonymous questionnaires were collected. The surveyed institution has established 24 types of ABSL (Animal Biosafety Laboratory) and biosafety management organizations and systems equipped with safety equipment. Our study also suggests that the principal of the laboratory establishment fails to perform supervision and inspection responsibilities, the inappropriate design of the animal biosafety laboratory, non-standardized personnel training and health management, non-strict waste management, and insufficient emergency management. The administrative department and work units should address certain safety and occupational health risks in laboratory animal research. The author proposes control strategies based on organizational guarantee, personnel management, emergency management, etc., to help prevent risks and ensure occupational health. Due to regional limitations and small sample size, the results may not be generalisable to all parts of the world. However, some of the key common issuesmay also be present in other regions, sowe believe that this research still has some relevance.

Keywords

Acknowledgement

We thank Zhi-kun Lin of Fuzhou Zhaofenghua Biotechnology Co., Ltd for providing vital support and guidance. The language editing received great help from Mr. Wen-zheng Yu, MS in Marketing Analytics at Illinois Institute of Technology.

References

  1. McCormick-Ell J, Connell N. Laboratory safety, biosecurity, and responsible animal use. ILAR J 2019;60:24-33. https://doi:10.1093/ilar/ilz012. 
  2. Qasmi SA, Khan BA. Survey of suspected laboratory-acquired infections and biosafety practices in research, clinical, and veterinary laboratories in Karachi, Pakistan. Health Secur 2019;17:372-83. https://doi:10.1089/hs.2019.0057. 
  3. Gunther S, Feldmann H, Geisbert TW, Hensley LE, Rollin PE, Nichol ST, Stroher U, Artsob H, Peters CJ, Ksiazek TG, Becker S, Meulen J, Olschlager S, Schmidt-Chanasit J, Sudeck H, Burchard GD, Schmiedel S. Management of accidental exposure to Ebola virus in the biosafety level 4 laboratory, Hamburg, Germany. J Infect Dis 2011;204:785-90. https://doi:10.1093/infdis/jir298. 
  4. Anonymous. Russian scientist dies after Ebola lab accident. Science 2004;304:1225b. Available from: https://www.smh.com.au/world. 
  5. Emond RT, Evans B, Bowen ET, Lloyd G. A case of Ebola virus infection. Br Med J 1977;2:541-4. https://doi:10.1136/bmj.2.6086.541. 
  6. Order No. 424 of the State Council of PRC. The regulations on the biosafety management of pathogenic microbial laboratories; 2018. 
  7. Order No. 2 of the National Science and Technology Commission of PRC. The regulations on the management of laboratory animal; 2017. 
  8. Kortepeter MG, Martin JW, Rusnak JM, Cieslak TJ, Warfield KL, Anderson EL, Ranadive MV. Managing potential laboratory exposure to Ebola virus by using a patient biocontainment care unit. Emerg Infect Dis 2008;14:881-7. https://doi:10.3201/eid1406.071489. 
  9. Ministry of Housing and Urban Rural Development of PRC. The technical specifications for building laboratory animal facilities(GB50447-2008; 2008. 
  10. Collins DE, Reuter JD, Rush HG. Viral vector biosafety in laboratory animal research. Comp Med 2017;67:215-21. https://pubmed.ncbi.nlm.nih.gov/ 28662750/. 
  11. Pritt S, Hankenson FC, Wagner T, Tate S. The basics of animal biosafety and biocontainment training. Lab Anim (NY) 2007;36:31-8. https://doi:10.1038/laban0607-31. 
  12. No. 545,Development finance department of the science and Technology Commission of PRC.the measures for the administration of laboratory animal licenses (Trial); 2001. 
  13. Chamberlain AT, Burnett LC, King JP, Whitney ES, Kaufman SG, Berkelman RL. Biosafety training and incident-reporting practices in the United States: a 2008 survey of biosafety professionals. Appl Biosaf 2009;14:135-43. https://doi:10.1177/153567600901400305. 
  14. Curtin-Brosnan J, Paigen B, Hagberg KA, Langley S, O'Neil EA, Krevans M, Eggleston PA, Matsui EC. Occupational mouse allergen exposure among nonmouse handlers. J Occup Environ Hyg 2010;7:726-34. https://doi:10.1080/15459624.2010.530906. 
  15. Peng RD, Paigen B, Eggleston PA, Hagberg KA, Krevans M, Curtin-Brosnan J, Benson C, Shreffler WG, Matsui EC. Both the variability and level of mouse allergen exposure influence the phenotype of the immune response in workers at a mouse facility. J Allergy Clin Immunol 2011;128:390-6. https://doi:10.1016/j.jaci.2011.04.050. 
  16. Schweitzer IB, Smith E, Harrison DJ, Myers DD, Eggleston PA, Stockwell JD, Paigen B, Smith AL. Reducing exposure to laboratory animal allergens. Comp Med 2003;53:487-92. https://pubmed.ncbi.nlm.nih.gov/14655990/. 
  17. Guo M, Wang Y, Liu J, Huang ZX, Li XD. Biosafety and data quality considerations for animal experiments with highly infectious agents at ABSL-3, facilities. J Biosaf Biosecur 2019;1:50-5. https://doi:10.1016/j.jobb.2018.12.011.