대한한의학방제학회지 (Herbal Formula Science)

  • 제32권1호
  • /
  • Pages.39-49
  • /
  • 2024
  • /
  • 1229-1218(pISSN)
  • /
  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지
DOI QR코드

DOI QR Code

작약감초탕 가 현호색의 항염증 기전에 대한 네트워크 약리학적 분석

Network pharmacology analysis of Jakyakgamchotang with corydalis tuber for anti-inflammation

  • 김영식 (우석대학교 한의과대학 본초학교실) ;
  • 김홍준 (우석대학교 한의과대학 방제학교실) ;
  • 박한빈 (우석대학교 한의과대학 방제학교실) ;
  • 이승호 (우석대학교 한의과대학 병리학교실)
  • Young-Sik Kim (Department of Herbology, College of Korean Medicine, Woosuk University) ;
  • Hongjun Kim (Department of Fomula Science, College of Korean Medicine, Woosuk University) ;
  • Han-bin Park (Department of Fomula Science, College of Korean Medicine, Woosuk University) ;
  • Seungho Lee (Department of Pathology, College of Korean Medicine, Woosuk University)
  • 투고 : 2023.12.07
  • 심사 : 2024.02.06
  • 발행 : 2024.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives : The purpose of this study was to investigate the molecular targets and pathways of anti-inflammatory effects of Jakyakgamchotang with corydalis tuber (JC) using network pharmacology. Methods : The compounds in constituent herbal medicines of JC were searched in TCM systems pharmacology (TCMSP). Target gene informations of the components were collected using chemical-target interactions database provided by Pubchem. Afterwards, network analysis between compounds and inflammation-related target genes was performed using cytoscape. Go enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed on inflammation-related targets using DAVID database. Results : 70 active compounds related to inflammation were identified, and 295 target genes related to the anti-inflammatory activity of the compound of JC were identified. In the Go biological process DB and KEGG pathway DB, "inflammatory response", "cellular response to lipopolysaccharide", "positive regulation of interleukin-6 production", and "positive regulation of protein kinase B. signaling", "positive regulation of ERK1 and ERK2 cascade", "positive regulation of I-kappaB kinase/NF-kappaB signaling", "negative regulation of apoptotic process", and "PI3K-Akt signaling pathway" were found to be mechanisms related to the anti-inflammatory effects related to the target genes of JC. The main compounds predicted to be involved in the anti-inflammatory effect of JC were quercetin, licochalcone B, (+)-catechin, kaempferol, and emodin. Conclusions : This study provides the molecular targets and potential pathways of JC on inflammation. It can be used as a basic data for using JC for various inflammatory disease in traditional korean medicine clinic.

키워드

과제정보

이 논문은 우석대학교 교내학술연구비 지원에 의하여 연구됨

참고문헌

  1. Lee GE, Ryu YS, Kang H-W. Study of Pathologic Mechanism Related Chiljeong-Based on a Literature Review of Donguibogam. J of Oriental Neuropsychiatry. 2014;25(1):85-108.
  2. Kim DH, Seo B-I, Kim BK, Kim GC, Shin SS. Standard Principles for the Designing of Prescriptions - The Theory for Monarch, Minister, Adjuvant and Dispatcher. Herb. Formula Sci. 2003;11(2):1-18.
  3. Moncrieff J. Research on a "drug-centred" approach to psychiatric drug treatment: Assessing the impact of mental and behavioural alterations produced by psychiatric drugs. Epidemiol Psychiatr Sci. 2018;27(2): 133-40.
  4. Shin YS, Lee SI. A Review Study of Researches on Jakyakgamcho-tang. Herb. Formula Sci. 2017;25(2):271-302.
  5. Ahn HS, Park YB, Kang SK. Effects of the Corydalis Tuber Aqua - acupuncture on the Pain and Convulsion in Mice and Gastric Ulcer in Rats. Journal of Acupuncture Research. 1994;11(1):99-111.
  6. Tian B, Tian M, Huang S-M. Advances in phytochemical and modern pharmacological research of Rhizoma Corydalis. Pharm Biol. 2020;58(1):265-75.
  7. Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, Xu X, Li Y, Wang Y, Yang L. TCM-SP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 2014;6(1):13.
  8. Arulselvan P, Fard MT, Tan WS, Gothai S, Fakurazi S, Norhaizan ME, Kumar SS. Role of Antioxidants and Natural Products in Inflammation. Oxid Med Cell Longev. 2016;2016:5276130.
  9. Lim H-S, Kim YJ, Kim OS, Jeong S-J. Screening of 50 Korean Herbal formulas with Inhibitory Effects on Acetylcholinesterase Activity and Amyloid-β Aggregation. Kor. J. Pharmacogn. 2016;47(3): 287-94.
  10. Lee D-Y, Lee H-S, Jo J-H, Yi Y-W, Kim S-J, Kang K, Kwon T-W, Yang SG, Lee I-H. Comparison of Ingredients and Activities of Danggwisoo-san and Jakyakgamcho-tang by Extraction Method. J Korean Med Rehabil. 2020;30(4):31-9.
  11. Yang S-H, Eom K-J, Baek S-H, Kang K-R, Lee M-S. The Effects of Jakyakgamcho Pharmacopuncture on Acute Cervical Pain after Whiplash Injury, 5 Cases. J Int Korean Med. 2014;195-203.
  12. Kim TH, Jeong SH, Yoon TK, Lee SJ, Shin SJ, Kwon OJ. A Comparison of the Effect of Shinbaro Pharmacopuncture and Jakyakgamcho Decoction Pharmacopuncture Treatments in Patients with Low Back Pain Caused by Traffic Accidents : A Retrospective, Case Series Observational Study. The Acupuncture. 2015;32(4):157-65.
  13. Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y. Quercetin, Inflammation and Immunity. Nutrients. 2016;8(3):167.
  14. Yang R, Yuan BC, Ma YS, Zhou S, Liu Y. The anti-inflammatory activity of licorice, a widely used Chinese herb. Pharm Biol. 2017;55(1):5-18.
  15. Huang J, Zhu Y, Li S, Jiang H, Chen N, Xiao H, Liu J, Liang D, Zheng Q, Tang J, Meng X. Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway. Redox Rep. 2023;28(1):2243423.
  16. Baranwal A, Aggarwal P, Rai A, Kumar N. Pharmacological Actions and Underlying Mechanisms of Catechin: A Review. Mini Rev Med Chem. 2022;22(5):821-33.
  17. Kadioglu O, Nass J, Saeed ME, Schuler B, Efferth T. Kaempferol Is an Anti-Inflammatory Compound with Activity towards NF-κB Pathway Proteins. Anticancer Res. 2015;35(5):2645-50.
  18. Hyun MS, Hur JM, Mun YJ, Kim D, Woo WH. BBR induces apoptosis in HepG2 cell through an Akt-ASK1-ROS-p38MAPKs-linked cascade. J Cell Biochem. 2010;109(2):329-38.
  19. Guney E, Menche J, Vidal M, Barabasi AL. Network-based in silico drug efficacy screening. Nat Commun. 2016;7:10331.