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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Longevity through diet restriction and immunity

  • Jeong-Hoon Hahm (Aging and Metabolism Research Group, Korea Food Research Institute) ;
  • Hyo-Deok Seo (Aging and Metabolism Research Group, Korea Food Research Institute) ;
  • Chang Hwa Jung (Aging and Metabolism Research Group, Korea Food Research Institute) ;
  • Jiyun Ahn (Aging and Metabolism Research Group, Korea Food Research Institute)
  • Received : 2023.06.06
  • Accepted : 2023.07.14
  • Published : 2023.10.31
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Abstract

The share of the population that is aging is growing rapidly. In an aging society, technologies and interventions that delay the aging process are of great interest. Dietary restriction (DR) is the most reproducible and effective nutritional intervention tested to date for delaying the aging process and prolonging the health span in animal models. Preventive effects of DR on age-related diseases have also been reported in human. In addition, highly conserved signaling pathways from small animal models to human mediate the effects of DR. Recent evidence has shown that the immune system is closely related to the effects of DR, and functions as a major mechanism of DR in healthy aging. This review discusses the effects of DR in delaying aging and preventing age-related diseases in animal, including human, and introduces the molecular mechanisms that mediate these effects. In addition, it reports scientific findings on the relationship between the immune system and DR-induced longevity. The review highlights the role of immunity as a potential mediator of the effects of DR on longevity, and provides insights into healthy aging in human.

Keywords

Acknowledgement

This work was supported by Korea Food Research Institute (E0210101).

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