Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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In Vivo Effects of Crataegus pinnatifida Extract for Healthy Longevity

  • In-sun Yu (Division of Food Functionality Research, Korea Food Research Institute) ;
  • Mina K. Kim (Department of Food Science and Human Nutrition and K-Food Research Center, Jeonbuk National University) ;
  • Min Jung Kim (Division of Food Functionality Research, Korea Food Research Institute) ;
  • Jaewon Shim (Department of Biochemistry, Kosin University College of Medicine)
  • Received : 2023.02.16
  • Accepted : 2023.03.07
  • Published : 2023.05.28
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Abstract

Aging is a complex series of multi-organ processes that occur in various organisms. As such, an in vivo study using an animal model of aging is necessary to define its exact mechanisms and identify anti-aging substances. Using Drosophila as an in vivo model system, we identified Crataegus pinnatifida extract (CPE) as a novel anti-aging substance. Regardless of sex, Drosophila treated with CPE showed a significantly increased lifespan compared to those without CPE. In this study, we also evaluated the involvement of CPE in aging-related biochemical pathways, including TOR, stem cell generation, and antioxidative effects, and found that the representative genes of each pathway were induced by CPE administration. CPE administration did not result in significant differences in fecundity, locomotion, feeding amount, or TAG level. These conclusions suggest that CPE is a good candidate as an anti-aging food substance capable of promoting a healthy lifespan.

Keywords

Acknowledgement

This work was supported by a grant to JS from Kosin University College of Medicine (2021) and from the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology (NRF-2017R1C1B2006455 and NRF-2022R1F1A1076324).

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