The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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A traditional East Asian herbal complex, Majainhwan for constipation in Parkinson's disease: A retrospective study

  • Jun Ho Cho (Department of Korean Medicine Cardiology and Neurology, Graduate School, Kyung Hee University) ;
  • Chul Jin (Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University) ;
  • Seungwon Kwon (Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University) ;
  • Seung-Yeon Cho (Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University) ;
  • Seong-Uk Park (Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University) ;
  • Woo-Sang Jung (Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University) ;
  • Sang-Kwan Moon (Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University) ;
  • Jung-Mi Park (Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University) ;
  • Chang-Nam Ko (Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University) ;
  • Ki-Ho Cho (Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University)
  • Received : 2022.06.27
  • Accepted : 2022.11.09
  • Published : 2022.12.01
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Abstract

Objectives: Parkinson's disease (PD) patients experience various non-motor symptoms, among which constipation is the second most common after anosmia. However, there are no clear guidelines or effective treatment for constipation in PD. Methods: To investigate the efficacy of Majainhwan (MH) on constipation in patients with PD, we conducted a retrospective chart review study of PD or Parkinsonism patients with constipation who received outpatient or inpatient treatment and whose previous laxatives were replaced by MH from August 2016 to July 2019. Results: In this study, a total of 68 patients' medical records were reviewed. Among the 44 outpatients with MH treatment, "effective" results were observed in 86.4% patients. Similarly, among the 24 inpatients, "effective" results were noted in 95.8% patients. The adverse effect was "diarrhea" reported in five cases. Conclusion: Based on these findings, we could suggest that MH is relatively safe and may be effective in the treatment of constipation in patients with PD.

Keywords

Acknowledgement

This paper is based on Jun Ho Cho's theses for Master's Degree

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