Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis

  • Kim, Jihyun (Laboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine) ;
  • Ryu, Seungwon (Laboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine) ;
  • Kim, Hye Young (Laboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine)
  • Received : 2021.03.06
  • Accepted : 2021.03.30
  • Published : 2021.05.31
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Abstract

Innate lymphoid cells (ILCs) are the most recently discovered family of innate immune cells. ILCs can be categorized into three groups on the basis of the transcription factors that direct their functions and the cytokines they produce. Notably, these functions parallel the effector functions of T lymphocytes. ILCs play a frontline role in host defense and tissue homeostasis by responding rapidly to environmental factors, conducting effector responses in a tissue-specific manner, and interacting with hematopoietic and non-hematopoietic cells throughout the body. Moreover, recent studies reveal that ILCs are involved in development of various inflammatory diseases, such as respiratory diseases, autoimmune diseases, or cancer. In this review, we discuss the recent findings regarding the biology of ILCs in health and inflammatory diseases.

Keywords

Acknowledgement

This study was supported by a grant from the National Research Foundation of Korea (NRF-2019R1A2C2087574) and a grant from the MD-PhD/Medical Scientist Training Program through the Korea Health Industry Development Institute (KHIDI), which was funded by the Ministry of Health & Welfare, Republic of Korea.

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