Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Development of Fluorescent Small Molecules for Imaging of Alzheimer's Disease Biomarkers

알츠하이머병의 영상 진단을 위한 형광 프로브의 개발

  • Min, Changho (Department of Applied Chemistry, School of Applied Chemical Engineering, Kyungpook National University) ;
  • Ha, Heonsu (Department of Applied Chemistry, School of Applied Chemical Engineering, Kyungpook National University) ;
  • Jeon, Jongho (Department of Applied Chemistry, School of Applied Chemical Engineering, Kyungpook National University)
  • 민창호 (경북대학교 공과대학 응용화학공학부 응용화학과) ;
  • 하헌수 (경북대학교 공과대학 응용화학공학부 응용화학과) ;
  • 전종호 (경북대학교 공과대학 응용화학공학부 응용화학과)
  • Received : 2020.11.11
  • Accepted : 2020.11.26
  • Published : 2021.02.10
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Abstract

Alzheimer's disease (AD), an irreversible degenerative disorder, is associated with accumulation and aggregation of amyloid-β peptides, hyperphosphorylated tau proteins, and high level of metal ions in the brain. Up to date, there is no effective therapeutic agent to stop the progress of the disease and thus early and accurate diagnosis of AD has gained increasing attention in recent years. Among several diagnostic methods, an optical imaging using fluorescent probes is one of the most promising tools to visualize AD biomarkers. In this review, we will introduce fluorescent probes that can be applied to in vivo brain imaging of AD models and also their structure. It is expected that the present review will provide useful information to many scientists in the related research fields.

알츠하이머병은 신경퇴행질환으로 뇌조직에서 발생하는 아밀로이드 베타(amyloid-β, Aβ) 펩타이드의 축적과 응집, 타우 단백질의 초인산화, 고농도의 특정 금속이온 축적에 의해 발병하는 것으로 알려져 있다. 현재까지 효과적인 치료제가 개발되지 못하였기 때문에, 알츠하이머병을 초기에 정확하게 진단하는 기술은 매우 중요하다. 알츠하이머병의 진단을 위해 개발된 다양한 기법 중 형광 프로브를 이용한 알츠하이머병의 바이오마커 영상화는 많은 연구자들의 관심을 받고 있다. 본 리뷰 논문에서는 최근 개발된 알츠하이머병 진단용 형광 프로브의 구조와, 체내 뇌 영상화에의 적용을 소개하고자 한다. 본 논문은 향후 새로운 프로브를 개발하고자 하는 연구자들에게 많은 도움이 될 것으로 기대된다.

Keywords

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