Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Application of biodegradable metal based drug delivery carrier on Foot and Mouth Disease vaccination in pigs

돼지에서 생체 분해 금속성 전달체를 활용한 구제역 백신의 적용 연구

  • Cho, Ara (Division of Animal Diseases & Health, National Institute of Animal Science, RDA) ;
  • Oh, Sang-Ik (Division of Animal Diseases & Health, National Institute of Animal Science, RDA) ;
  • Choe, Changyong (Division of Animal Diseases & Health, National Institute of Animal Science, RDA) ;
  • Jung, Young-Hun (Division of Animal Diseases & Health, National Institute of Animal Science, RDA) ;
  • Do, Yoon Jung (Division of Animal Diseases & Health, National Institute of Animal Science, RDA) ;
  • Kim, Suhee (Division of Animal Diseases & Health, National Institute of Animal Science, RDA) ;
  • Choo, Hyun Wook (LABnPEOPLE Co. Ltd.) ;
  • Gu, Jong Su (LABnPEOPLE Co. Ltd.) ;
  • Chung, Woo-Jin (LABnPEOPLE Co. Ltd.) ;
  • Cho, Sung Youn (LABnPEOPLE Co. Ltd.) ;
  • Yoo, Jae Gyu (Division of Animal Diseases & Health, National Institute of Animal Science, RDA)
  • 조아라 (농촌진흥청 국립축산과학원 가축질병방역과) ;
  • 오상익 (농촌진흥청 국립축산과학원 가축질병방역과) ;
  • 최창용 (농촌진흥청 국립축산과학원 가축질병방역과) ;
  • 정영훈 (농촌진흥청 국립축산과학원 가축질병방역과) ;
  • 도윤정 (농촌진흥청 국립축산과학원 가축질병방역과) ;
  • 김수희 (농촌진흥청 국립축산과학원 가축질병방역과) ;
  • 추현욱 (랩앤피플) ;
  • 구종수 (랩앤피플) ;
  • 정우진 (랩앤피플) ;
  • 조성윤 (랩앤피플) ;
  • 류재규 (농촌진흥청 국립축산과학원 가축질병방역과)
  • Received : 2020.03.30
  • Accepted : 2020.06.24
  • Published : 2020.09.30
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Abstract

In this study, we applied biodegradable drug delivery carries (BDDC) for food-and-mouth (FMD) vaccination. After FMD vaccination using BDDC, we estimated the percentage inhibition (PI) of antibody, decomposed patterns, and histopathologic features of BDDC. PI of antibody was higher than 50 at two weeks after injection and sustained positive PI until 10 weeks after injection. BBDC injection group showed significantly an increased pattern of blood monocyte at two and three weeks after injection. According to the Micro CT, micro-cracks were observed at two weeks after injection and the morphology of BDDC was lost at four weeks after injection. For histopathological examination, acute inflammation with neutrophil infiltration and micro-metallic residues were observed around BDDC until four weeks after injection and inflammatory responses gradually decreased at 10 weeks. Based on our experiment, BDDC is considered as an alternative way to vaccine injection for veterinary applications. Our study can be used as basic data for the drug delivery system using biodegradable metals in the future.

Keywords

References

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