The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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A Case Report: Effect of Korean Medicine Including Distilled Form of Bosaeng-tang Gagambang on Moderate to Severe Hyperemesis Gravidarum.

  • Kim, Hae-Won (Dept. of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Daejeon University) ;
  • Baek, Seon-Eun (Dept. of Korean Medicine Obstetrics & Gynecology, Daejeon Korean Medicine Hospital of Dae-jeon University) ;
  • Yoo, Dong-Youl (Dept. of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Daejeon University) ;
  • Yoo, Jeong-Eun (Dept. of Korean Medicine Obstetrics & Gynecology, College of Korean Medicine, Daejeon University)
  • Received : 2020.10.05
  • Accepted : 2020.11.25
  • Published : 2020.12.01
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Abstract

Objectives: Hyperemesis gravidarum (HG) is defined as severe nausea and vomiting during pregnancy (NVP) with weight loss, ketonuria, and electrolyte imbalance. Many NVP or HG patients get hard to take herbal medicine since the smell and taste of it. Therefore, the distilled herbal medicines are often used in clinical practice. A 32-year-old, 14-week pregnant female was admitted for 3 weeks at a Korean medicine hospital. She was experiencing HG accompanied by 19.61% (10 kg) weight loss, ketonuria, and electrolyte imbalance. The patient received Bosaeng-tang gagambang in its distilled form, acupuncture, electro-acupuncture, sticker needles, cupping, moxibustion, and hydration during admission. The severity and frequency of NVP, weight loss, and ketonuria significantly improved without any side effects. Before the therapy, she admitted to two obstetrics and gynecology hospitals, 1 week each, with no improvement. This case presents the therapeutic potential of Korean medicine including herbal medicine in its diluted form for HG and NVP.

Keywords

References

  1. Whitehead SA, Andrews PLR and Chamberlain GVP. Characterisation of nausea and vomiting in early pregnancy: a survey of 1000 women. J Obstet Gynaecol 1992;12:364-9. https://doi.org/10.3109/01443619209025932
  2. Park JS and Lim EM. A case report of 1 patient complaining of hyperemesis gravidarium. Korean Obstet Gynecol. 2005;18(1):234-41.
  3. DB Fell, L Dodds, KS Joseph, VM Allen and B Butler. Risk factors for hyperemesis gravidarum requiring hospital admission during pregnancy. Obstet Gynecol. 2006;107(2Pt1):277-84. https://doi.org/10.1097/01.AOG.0000195059.82029.74
  4. ML Badell, SM Ramin and JA Smith. Treatment options for nausea and vomiting during pregnancy. Pharmacotherapy. 2006;26(9):1273-87. https://doi.org/10.1592/phco.26.9.1273
  5. P Mazzotta, DE Stewart, G Koren and LA Magee. Factors associated with elective termination of pregnancy among Canadian and American women with nausea and vomiting of pregnancy. J Psychosom Obstet Gynaecol. 2001;22(1):7-12. https://doi.org/10.3109/01674820109049946
  6. Poursharif B, Korst LM, Fejzo MS, MacGibbon KW, Romero R, and Goodwin TM. The psychosocial burden of illness of hyperemesis gravidarum. J Perinatol 2008;28:176-81. https://doi.org/10.1038/sj.jp.7211906
  7. M.F.G. Verberg, D.J. Gillott, N.Al-Fardan and J.G.Grudzinskas. Hyperemesis gravidarum, a literature review. Hum. Reprod. Update. 2005;11(5):527-39. https://doi.org/10.1093/humupd/dmi021
  8. Hwang BC and Kim SY. The effectiveness of antiemetics in hyperemesis gravidarum. J Korean Obstet Gynecol.. 2010;53(1):15-22. https://doi.org/10.5468/kjog.2010.53.1.15
  9. Riley TR, Chinchilli VM, Shoemaker M and Koch K. Is nausea associated with chronic hepatitis C infection? Am J Gastroenterol 2001;96(12):3356-60. https://doi.org/10.1016/S0002-9270(01)03899-0
  10. Kim YG, Kim DC and Baek SH. A Clinical Analysis of 50 fetus that using Herbal Medication during Pregnancy. J Korean Obstet Gynecol. 2003;16(4):136-43.
  11. American College of Obstetrics and Gynecology. ACOG (American College of Obstetrics and Gynecology) Practice Bulletin: nausea and vomiting of pregnancy. Obstet Gynecol. 2004; 103:803-14. https://doi.org/10.1097/00006250-200404000-00045
  12. Atanackovic Z, Navioz Y, Mpretti M, and Koren G. The safety of higher than standard dose of doxylamine-pyridoxine (diclectin) for nausea and vomiting of pregnancy. J. Clin. Pharmacol. 2001;41:842-5. https://doi.org/10.1177/00912700122010735
  13. N Persaud, C Meaney, K El-Emam, R Moineddin and K Thorpe. Doxylamine -pyridoxine for nausea and vomiting of pregnancy randomized placebo controlled trial: Prespecified analyses and reanalysis. PLOS one. 2018.13(1):e0189978. https://doi.org/10.1371/journal.pone.0189978
  14. The society of Korean medicine obstetrics and gynecology. Oriental obstetrics & gynecologyII. 1st ed. Seoul: Euiseongdang; 2012, p.493-9.
  15. Lee C. Uihak-ipmun. Seoul: Daesung; 1984, p.1, 53, 320.
  16. Kim DY. Guide training for the care of pregnant women who are targeted for the National happiness card (former Goun-mom card). The Association of Korean Medicine. 2015. Available from: URL: http://www.akom.org/Edu/EduAkomArticleNews?id=624822&eduNewsType=1. Accessed July 6, 2020.
  17. Ahn IS, Kim DI, Choi MS and Kim SH. The analysis of delivery outcomes in cases of hyperemesis gravidarum patients medicated with Pinelliae Rhizoma - to establish a guideline in administration of Pinelliae Rhizoma. J Korean Obstet Gynecol. 2014;27(3):94-103. https://doi.org/10.15204/JKOBGY.2014.27.3.094
  18. Yun YW. Evaluation for reproductive & developmental toxicity and the study for mechanisms (II): TRC. Korea Food & Drug Administration. 2004. Available from: URL: http://www.ndsl.kr/ndsl/commons/util/ndslOriginalView.do?dbt=TRKO&cn=TRKO201000016097&rn=&url=&pageCode=PG18. Accessed May 12, 2020.
  19. Lee SJ, Lee SY and Yu SA. A Survey of Actual Guides for Children to Take the Oriental Medicine in the Oriental Clinics & the Oriental Hospitals. J Pediatr Korean Med. 2013;27(3):12-9. https://doi.org/10.7778/jpkm.2013.27.3.012
  20. Kim JA and Kim DC. A case report of a triplets pregnant patient by in vitro fertilization with hyperemesis gravidarum. J Korean Obstet Gynecol. 2015;28(4):118-25. https://doi.org/10.15204/jkobgy.2015.28.4.118
  21. Kim TH, Choi CM, Hong SE, Lee JJ and Yoo SK. Clinical study for the 20cases of the hyperemesis patients prescribed Kakambosengtang who have weakness of the spleen and stomach. J Korean Obstet Gynecol. 2002;15(1):128-38.
  22. Choi SM. Study on the gas chromatography of Samul-tang, Sakunja-tang and their distillate. Korean J. Oriental Physiology & Pathology. 2006;20(4):942-5.
  23. Lee JW, Jang MH, Choi JS and Ahn TW. The effect of Yongyukjowitang distillate on the immune activity of spleen cells of aged rats. JSCM. 2013;25(3):218-32.
  24. Lee CH, Kim IH, Kim YE, Kim YJ, Hwang JH and Yu KW. Effect of steam distillates prepared from herbal medicines on immunostimulating activity. J Korean Soc Food Sci Nutr. 2004;33(4):626-32. https://doi.org/10.3746/JKFN.2004.33.4.626
  25. Shim SM, Kim TS and Koh YT. A case of distillation herbal medicine and counseling on insomnia. J of Oriental Neuropsychiatry. 2006;17(2):217-25.
  26. Jang SW, Ahn IS, Choi MS and Kim DI. Review on RCT research papers related nausea and vomiting in pregnancy - Focusing on acupoint treatment -. J Korean Obstet Gynecol. 2013;26(2):138-50. https://doi.org/10.15204/jkobgy.2013.26.2.138
  27. Van den Heuvel E, Goossens M, Vanderhaegen H, Sun HX and Buntinx F. Effect of acustimulation on nausea and vomiting and on hyperemesis in pregnancy: a systematic review of Western and Chinese literature. BMC Complement Altern Med. 2016;16:13.
  28. Kenneth LK. Unexplained Nausea and Vomiting. Curr Treat Options Gastroenterol. 2000;3(4):303-313. https://doi.org/10.1007/s11938-000-0044-5
  29. Koren G, Boskovic R, Hard M, Maltepe C, Navoiz Y and Einarson A. Motherisk-PUQE (pregnancy-unique quantification of emesis and nausea) scoring system for nausea and vomiting of pregnancy. Am. J. Obstet. Gynecol. 2002;186(5):228-31.
  30. ML Badell, SM Ramin and JA Smith. Treatment options for nausea and vomiting during pregnancy. pharmacotherapy. 2006;26(9):1273-87. https://doi.org/10.1592/phco.26.9.1273