The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Long-Term Intake of Korean Medicine on Gynecology Patients' Livers and Kidneys; Panel Study - Focus on Before Intake, After 3, 6 Months -

장기간 한약복용이 부인과 환자의 간 및 신장기능에 미치는 영향: panel연구 - 복용 전과 후 3, 6개월 비교를 중심으로 -

  • Yang, Junmo (Jayoon Korean medical clinic) ;
  • Sung, Dongmin (Development of Korean Medicine Policy, National Institute for Korean Medicine) ;
  • Kim, Eu Gene (Seoul Health Foundation) ;
  • Lee, Sundong (Dept. of Preventive Medicine, College of Korean Medicine, Sangji University)
  • 양준모 (자윤한의원) ;
  • 성동민 (한국한의약진흥원 정책본부) ;
  • 김유진 (서울특별시 공공보건의료재단 지역보건사업부) ;
  • 이선동 (상지대학교 한의과대학 예방의학교실)
  • Received : 2020.02.13
  • Accepted : 2020.02.28
  • Published : 2020.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: To observe the effects on liver and kidney of gynecology patients' during long term Korean Medicine. Methods: This research was conducted as a panel study on 29 female gynecology patients at Korean medicine clinic and compares their conditions before, 3 months after, and 6 months after Intake of Korean medicine. This analysis was conducted to frequency(%), repeated measure ANOVA and significantly statistics was p<0.05, confidence interval. Results: The most common conditions among the subjects were polycystic ovary syndrome, endometriosis, adenomyosis, and uterine myoma. Except in a few instances, liver functions (AST, ALT, γ-GTP) were within the normal range before and after the intake of Korean medicine. Further, while there was a slight change in liver functions when three months and six months after the intake, but there was no statistical significance (p>0.05). As for the kidney functions (BUN, Creatinine, BUN/Creatinine), they were within the normal range before and after the intake of Korean medicine. Further, while there was a slight change in kidney functions three months and six months after the intake, there was no statistical significance(p>0.05) either. Conclusions: Based on these results, it can be concluded that Korean medicine does not have a negative impact on the gynecology patients' liver and kidney.

Keywords

References

  1. Lee SD, Park YC. Toxicology for Herbal Medicine I. Seoul:Koreanstudies Information. 2012;45.
  2. Jung IK, Kim JS, Lee HS, Ryu SH, Kwak DI. The Survey of the Concept about Using Herb-Medication & the Effect on Treatment-Seeking Behavior in Psychiatric and Non-Psychiatric Patients. J Korean Neuropsychiatr Assoc. 2001;40(6):1031-43.
  3. Kim DJ. A preliminary multicenter study for the detection of toxic hepatitis induced by various plant preparations and healthy foods and the development of nationwide reporting system of toxic hepatitis. Korea Food & Drug Administration. 2003.
  4. Jang IS. A Review on the Report about Drug-induced Hepatitis published by the National Institute of Toxicological Research. J Korean Oriental Med. 2004;25(3):78-89.
  5. Cho BS, Kidney Disease and Herbal Medicine, Kidney and health. 2005;8(0):8-10.
  6. Kim SY. Efficacy versus Effectiveness. Korean J Fam Med. 2013;34(4):227. https://doi.org/10.4082/kjfm.2013.34.4.227
  7. Kim DI. Korean Medicine Clinical Care Guidelines for Infertility. 2010:54-73.
  8. Jang HJ, Yoon YK, Sun TC, Song WS, Kwon SK. A Study Of Effects on Renal Function from Continuous Long-Term Herbal Medication. Korean J Intern Med. 2004;25(4): 300-5.
  9. Kang MH, Sul MC, Moon JY, Lee SH. The clinical study of LFT levels in 117 out-patients while taking herbal medicine for 6 months. Korean J Orient Int Med. 2007;28(fal):107-12.
  10. Lee BC, Choi EJ. The Safety and Efficacy of Herbal Medicine for 107 Psoriasis Patients: A Retrospective Chart Review. J Korean Med. 2016;37(1):34-40. https://doi.org/10.13048/jkm.16004
  11. Lee J, Shin JS, Kim MR, Byun JH, Lee SY, Shin YS, et al. Liver enzyme abnormalities intaking traditional herbal medicine in Korea : A retro spective large sample cohort study of musculoskeletal disorder patients. J Ethnopharmacol. 2015;169:407-12. https://doi.org/10.1016/j.jep.2015.04.048
  12. Cho JH, Oh DS, Hong SH, Ko H, Lee NH, Park SE, et al. A nationwide study of the incidence rate of herb-induced liver injury in Korea. Arch Toxicol. 2017;91(12):4009-15. https://doi.org/10.1007/s00204-017-2007-9
  13. Samkwang Medical Laboratories. 2018 Comprehensive Inspection Brochure. Seoul: Samkwang Medical Laboratories. 2018:237-40
  14. Hosten AO. BUN and Creatinine. In : Walker HK, Hall WD, Hurst JW. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston:Butterworths. 1990:874-8
  15. Park JK, Jang SJ. Health Statistics with SPSS / PC +. Seoul:Woohyun. 1993
  16. Byun SH, Seo BI. A study on medicinal theory of Wang-Ang. Herbal Formula Science. 1999;7(1):77-87
  17. Kim HU, Ryu JY, Lee JO, Lee SY. A systems approach to traditional oriental medicine. Nat Biotechnol. 2015;(33):264-8
  18. Park YC, Park HM, Lee SD. Inducible Mechanisms for Hepatotoxicity caused by Traditional Korean Medicines in a View of Toxicology. J Korean Oriental Med. 2011;32(4):48-67.
  19. Kim DW, Oh SH, Lee EJ, Kim HK, An IH, et al. The Change of Renal Function in Diabetic Nephropathy and Chronic Renal Failure Patients with Long Term Herb Medication by Frequently Prescribed Formular. J Korean Oriental Med. 2004;18(4):1207-12.
  20. Lee SD, Park YC. Toxicology for Herbal Medicine II. Seoul:Koreanstudies Information. 2013:227-230
  21. Lim JH, Kim YS, Lee YN, Kim SK, Jung SK, Jang JY, et al. Clinical Characteristics and Pathological Findings in Patients with Toxic Hepatitis. Korean J Medicine. 2011;81(1):55-63.
  22. Kang SH, Kim JI, Jeong KH, Ko KH, Ko PG, Hwang SW, et al. Clinical characteristics of 159 cases of acute toxic hepatitis. Korean J Hepatol. 2008;14(4):483-92 https://doi.org/10.3350/kjhep.2008.14.4.483
  23. Lee WY, Park BC, Kim HS, Joung KO, Yoon SI, Kwon SK, et al. A case of acute interstitial nephropathy and toxic hepatitis after short-term herbal medication. Korean J Med. 2007:103-106.
  24. Lee HU, Baek HK, Baek KM, Kim JH, Kim JW, Shim JC, et al. Comparison of Liver Function and Kidney Function Test Score by Administration Period of Herbal Medication. J Int Korean Med. 2006;27(110)
  25. Korean Medicine Encyclopedia [Internet]. Endometriosis;2018 MAR 22[cited 2020 JAN 16]. Available from:URL: https://www.kmpedia.kr/contents/contents/contents_popup_full/content_id/137.
  26. Lee EY, Jung SH, Moon ES. A Study on Consumer Awareness and Intention to Take Herbal Medicine. Korean Society of Home Management Conference. 2007:136-46.
  27. Uchino S, Bellomo R, Goldsmith D. The meaning of the blood urea nitrogen/Creatinine ratio in acute kidney injury. Clin Kidney J. 2012;5:187-91. https://doi.org/10.1093/ckj/sfs013
  28. Kasper D, et al. Harrison's Principles of Internal Medicine. 16th. Seoul:McGraw-Hill. 2006:1976-80.

Cited by

  1. 경골 파혈산동탕(破血散疼湯)이 골절 생쥐의 골 유합에 미치는 영향 vol.30, pp.4, 2020, https://doi.org/10.18325/jkmr.2020.30.4.1
  2. 한약복용이 간기능에 미치는 영향 : 국내 문헌에 대한 체계적 고찰 vol.41, pp.6, 2020, https://doi.org/10.22246/jikm.2020.41.6.933