Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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An Overview of the Genetic Variations of the SARS-CoV-2 Genomes Isolated in Southeast Asian Countries

  • Yap, Polly Soo Xi (Department of Medical Microbiology, Faculty of Medicine, University of Malaya) ;
  • Tan, Tse Siang (Department of Anaesthesiology and Intensive Care, UKM Medical Centre) ;
  • Chan, Yoke Fun (Department of Medical Microbiology, Faculty of Medicine, University of Malaya) ;
  • Tee, Kok Keng (Department of Medical Microbiology, Faculty of Medicine, University of Malaya) ;
  • Kamarulzaman, Adeeba (Department of Medicine, Faculty of Medicine, University of Malaya) ;
  • Teh, Cindy Shuan Ju (Department of Medical Microbiology, Faculty of Medicine, University of Malaya)
  • Received : 2020.06.08
  • Accepted : 2020.06.21
  • Published : 2020.07.28
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Abstract

Monitoring the mutation dynamics of human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical in understanding its infectivity, virulence and pathogenicity for development of a vaccine. In an "age of mobility," the pandemic highlights the importance and vulnerability of regionalization and labor market interdependence in Southeast Asia. We intend to characterize the genetic variability of viral populations within the region to provide preliminary information for regional surveillance in the future. By analyzing 142 complete genomes from South East Asian (SEA) countries, we identified three central variants distinguished by nucleotide and amino acid changes.

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