Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Influencing Factors of Plasma Levels of Total Peroxide and Oxidative Stress Index in Retired Miners with Chronic Obstructive Pulmonary Disease

만성폐쇄성폐질환을 동반한 이직광부에서 혈장 총 Peroxide 및 산화스트레스 지수 수준에 미치는 영향요인

  • Lee, Jong Seong (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Shin, Jae Hoon (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Baek, Jin Ee (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service) ;
  • Jeong, Ji Yeong (Department of Medical Biotechnology, Dong-A University) ;
  • Choi, Byung-Soon (Institute of Occupation and Environment, Korea Workers' Compensation & Welfare Service)
  • 이종성 (근로복지공단 직업환경연구원) ;
  • 신재훈 (근로복지공단 직업환경연구원) ;
  • 백진이 (근로복지공단 직업환경연구원) ;
  • 정지영 (동아대학교 의약생명공학과) ;
  • 최병순 (근로복지공단 직업환경연구원)
  • Received : 2020.05.11
  • Accepted : 2020.06.21
  • Published : 2020.06.30
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Abstract

Objective: Chronic obstructive pulmonary disease(COPD) is characterized by persistent airflow limitations associated with chronic inflammatory response due to noxious particles or gases in the lung. Increasing oxidative stress associated with COPD. The aim of this study was to evaluate the influencing factors of biomarkers for oxidative stress in retired miners with COPD. Methods: The levels of total peroxide(TPx), total antioxidant capacity(TAC), and oxidative stress index(TPx/TAC ratio, OSI) in plasma as biomarkers for oxidative stress, serum C-reactive protein(CRP) as a biomarker for inflammation, and general characteristics were measured in 93 male subjects with COPD. COPD was defined as post bronchodilator FEV1/FVC<0.7 by spirometry. Results: Mean levels of TPx(p=0.013), TAC(p=0.010), OSI(p=0.040), and CRP(p=0.024) were higher in current smokers. Levels of TPx(β=0.445, p<0.001), TAC(β=0.490, p<0.001), and OSI(β=0.351, p<0.001) were related to CRP levels, and CRP levels were related to %FEV1 predicted(β=-0.295, p=0.003) and current smoking(β=0.214, p=0.032). Conclusions: These results suggest that oxidative stress was related to inflammation, and inflammation were related to decreasing %FEV1 predicted and current smoking in retired miners with COPD.

Keywords

References

  1. Agusti A, Edwards LD, Rennard SI, MacNee W, Tal-Singer R et al. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: A novel phenotype. PLoS One 2012;7:E37483 http://doi.org/10.1371/journal.pone.0037483
  2. Agusti AG, Noguera A, Sauleda J, Sala E, Pons J et al. Systemic effects of chronic obstructive pulmonary disease. Eur Respir J 2003;21:347-360 http://doi.org/10.1183/09031936.03.00405703
  3. Anderson SC & Cockayne S. Clinical Chemistry. Concepts & applications. New York, The McGraw-Hill Co.; 2003. p. 285-96
  4. Babior BM. NADPH-oxidase: an update. Blood 1999; 93(5):1464-1476 PMID:10029572 https://doi.org/10.1182/blood.v93.5.1464.405a32_1464_1476
  5. Barany T, Simon A, Szabo G, Benko R, Mezei Z et al. Oxidative Stress-Related Parthanatos of Circulating Mononuclear Leukocytes in Heart Failure. Oxid Med Cell Longev 2017;1249614 http://doi.org/10.1155/2017/1249614
  6. Barnes PJ. Mediators of chronic obstructive pulmonary disease. Pharmacol Rev 2004;56(4):515-48 http://doi.org/10.1124/pr.56.4.2
  7. ben Anes A, Fetoui H, Bchir S, ben Nasr H, Chahdoura H et al. Increased oxidative stress and altered levels of nitric oxide and peroxynitrite in Tunisian patients with chronic obstructive pulmonary disease: correlation with disease severity and airflow obstruction. Biol Trace Elem Res 2014;161(1):20-31 http://doi.org/10.1007 s12011-014-0087-4 https://doi.org/10.1007/s12011-014-0087-4
  8. Bergdahl IA, Tore'n K, Eriksson K, Hedlund U, Nilsson T et al. Increased mortality in COPD among construction workers exposed to inorganic dust. Eur Respir J 2004;23:402-406 http://doi.org/10.1183/09031936.04.00034304
  9. Chen YW, Leung JM, Sin DD. A systematic review of diagnostic biomarkers of COPD exacerbation. PLoS One 2016;11:E0158843 http://doi.org/10.1371/journal.pone.0158843
  10. Choi JK, Paek DM, Lee JO. Normal predictive values of spirometry in Korean population. Tuberc Respir Dis 2005;58:230-242 http://dx.doi.org/10.4046/trd.2005.58.3.230
  11. Coggon D & Anthony Newman TA. Coal mining and chronic obstructive pulmonary disease: a review of the evidence. Thorax 1998;53:398-407 PMID:9708233 https://doi.org/10.1136/thx.53.5.398
  12. Fabbri LM & Rabe KF. From COPD to chronic systemic inflammatory syndrome? Lancet 2007;370:797-799 http://doi.org/10.1016/S1473-3099(19)30281-6
  13. Fukui T, Yamauchi K, Maruyama M, Yasuda T, Kohno M et al. Significance of measuring oxidative stress in lifestyle-related diseases from the viewpoint of correlation between d-ROMs and BAP in Japanese subjects. Hypertens Res 2011;34(9):1041-1045 PMID:19403985 https://doi.org/10.1038/hr.2011.76
  14. Gan WQ, Man SFP, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta analysis. Thorax 2004;59:574-580 http://doi.org/10.1136/thx.2003.019588
  15. Gulumian M, Borm PJA, Vallyathan, Castranova V, Donaldson K et al. Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker's pneumoconiosis: a comprehensive review. J Toxicol Environ Health, Part B 2006;9:357-395 http://doi.org/10.1080/15287390500196537
  16. Hanta I, Kocabas A, Canacankatan N, Kuleci S, Seydaoglu G. Oxidant-antioxidant balance in patients with COPD. Lung 2006;184(2):51-55 http://doi.org/10.1007/s00408-005-2561-4
  17. Hirose H, Kawabe H, Komiya N, Saito I. Relations between serum reactive oxygen metabolites (ROMs) and various inflammatory and metabolic parameters in a Japanese population. J Atheroscler Thromb 2009;16(2):77-82 http://doi.org/10.5551/jat.e265
  18. Hurst JR, Donaldson GC, Perera WR, Wilkinson TM, Bilello JA et al. Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006;174: 867-874 http://doi.org/10.1164/rccm.200604-506OC
  19. Karadag F, Kirdar S, Karul AB, Ceylan E. The value of C-reactive protein as a marker of systemic inflammation in stable chronic obstructive pulmonary disease. Eur J Intern Med 2008;19:104-108 http://doi.org/10.1016/j.ejim.2007.04.026
  20. KATRD(Korean academy of tuberculosis and respiratory diseases). Guideline for COPD and asthma. Seoul: Seoul Medcus; 2005. p. 26-27
  21. Kostikas K, Papatheodorou G, Psathakis K, Panagou P, Loukides S: Oxidative stress in expired breath condensate of patients with COPD. Chest 2003; 124(4):1373-1380 PMID:14555568 https://doi.org/10.1378/chest.124.4.1373
  22. Lamprecht B, McBurnie MA, Vollmer WM, Gudmundsson G, Welte T et al. COPD in never smokers: results from the population-based burden of obstructive lung disease study. Chest 2011;139(4):752-763 http://doi.org/10.1378/chest.10-1253
  23. Larsson K. Aspects on pathophysiological mechanisms in COPD. J Intern Med 2007;262(3):311-340 http://doi.org/10.1111/j.1365-2796.2007.01837.x
  24. Lee JS, Shin JH, Baek JE, Jeong JY, Choi BS. Inflammation and oxidative stress as related to airflow limitation severity in retired miners with chronic obstructive pulmonary disease. J Kor Soc Occup Environ Hyg 2019:29(2):251-258 https://doi.org/10.15269/JKSOEH.2019.29.2.251
  25. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010. Lancet 2012;380:2095-2128 http://doi.org/10.1016/S0140-6736(12)61728-0
  26. MacNee W. Oxidants and COPD. Curr Drug Targets Inflamm Allergy 2005;4(6):627-41 http://doi.org/10.2174/156801005774912815
  27. Mak JC. Pathogenesis of COPD. Part II. Oxidative antioxidative imbalance. Int J Tuberc Lung Dis 2008;12(4):368-374 PMID:18371260
  28. Meijers JM, Swaen GM, Slangen JJ. Mortality of Dutch coal miners in relation to pneumoconiosis, chronic obstructive pulmonary disease, and lung function. Occup Environ Med 1997;54(10):708-713 PMID: 9404317 https://doi.org/10.1136/oem.54.10.708
  29. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R et al. Standardisation of spirometry. Eur Respir J 2005;26:319-338 http://doi.org/10.1183/09031936.05.00034805
  30. Morimoto M, Satomura S, Hashimoto T, Ito E, Kyotani S. Oxidative stress measurement and prediction of epileptic seizure in children and adults with severe motor and intellectual disabilities. J Clin Med Res 2016;8(6):437-444 http://doi.org/10.14740/jocmr2534w
  31. Pepys MB & Hirschfield GM. "C-reactive protein: a critical update". J Clin Invest 2003;111:1805-1812 http://doi.org/10.1172/JCI18921
  32. Porter DW, Hubbs AF, Mercer R, Robinson VA, Ramsey D et al. Progression of lung inflammation and damage in rats sfter cessation of silica inhalation. Toxicol Sci 2004;79:370-380 http://doi.org/10.1093/toxsci/kfh110
  33. Repine JE, BAST A, Lankhorst I, The Oxidative stress study group. Oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1997;156(2 Pt 1):341-357 http://doi.org/10.1164/ajrccm
  34. Schins RPF & Borm PJA. Mechanisms and mediators in coal dust induced toxicity: A review. Am Occup Hyg 1999;43(1):7-33 PMID:10028891 https://doi.org/10.1016/S0003-4878(98)00069-6
  35. Singh S, Verma SK, Kumar S, Ahmad MK, Nischal A et al. Evaluation of oxidative stress and antioxidant status in chronic obstructive pulmonary disease. Scand J Immunol 2017;85(2):130-137 http://doi.org/10.1111/sji.12498
  36. Strassmann R, Bausch B, Spaar A, Kleijnen J, Braendli O et al. Smoking cessation interventions in COPD: a network meta-analysis of randomised trials. Eur Respir J 2009;34:634-640 http://doi.org/10.1183/09031936.00167708
  37. Su B, Liu T, Fan H, Chen F, Ding H et al. Inflammatory markers and the risk of chronic obstructive pulmonary disease: A systematic review and metaanalysis. PLoS One 2016;11:E0150586 http://doi.org/10.1371/journal.pone.0150586
  38. Taylan M, Demir M, Kaya H, Selimoglu Sen H, Abakay O et al. Alterations of the neutrophil-lymphocyte ratio during the period of stable and acute exacerbation of chronic obstructive pulmonary disease patients. Clin Respir J 2017;11:311-317 http://doi.org/10.1111/crj.12336
  39. Tkacova R, Kluchova Z, Joppa P, Petrasova D, Molcanyiova A. Systemic inflammation and systemic oxidative stress in patients with acute exacerbations of COPD. Respir Med 2007;101(8):1670-1676 http://doi.org/10.1016/j.rmed.2007.03.005