• BMB Reports
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• 제33권5호
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• pp.407-411
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• 2000

The effects of heat shock, or all-trans retinoic acid, on the expression of the C-reactive protein mRNA in the HT-29 human colon carcinoma cells, as well as the functional role of the C-reactive protein as a molecular chaperone, were studied. The expression level of the C-reactive protein mRNA in the HT-29 cells was increased time-dependently when exposed to heat-shock, and dose-dependently when treated with all-trans retinoic acid. The activities of transglutaminase C and K in the HT-29 cells were significantly increased when treated with all-trans retinoic acid. The C-reactive protein prevented thermal aggregation of the citrate synthase and stabilized the target enzyme, citrate synthase. The C-reactive protein promoted functional refolding of the urea-denatured citrate synthase up to 40-70%. These results suggest that the C-reactive protein, which is induced in human colon carcinoma cells, when heated or treated with all-trans retinoic acid has in a part functional activity of the molecular chaperone.

• 한국치위생학회지
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• 제20권3호
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• pp.303-312
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• 2020

Objectives: The purpose of this study was to investigate the relationship between periodontal disease, number of remaining teeth with high-sensitivity C-Reactive protein in Korean adults aged 40 and older. Methods: The study used the Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-3), 2015. The study sample consisted of 3,883 aged 40 years or older who had completed the health survey and the health examination. Logistic regression analyses were performed to examine the odds ratios of high-sensitivity C-Reactive protein by periodontal disease and number of remaining teeth, adjusting for demographic characteristics, chronic diseases and oral health behavior-related variables. Results: When the demographic and chronic diseases were adjusted, the risk of high-sensitivity C-Reactive protein (hs-CRP) average 1.23 mg/L or higher was 1.36 times higher in patients with periodontal disease between the ages of 40 and 49, but it was not significant (OR=1.36; 95% CI=0.82-2.23). In addition, in the group of 0~23 remaining teeth aged 40~49 years, the risk of higher than the average 1.23 mg/L of high-sensitivity C-Reactive protein was 2.03 times higher (OR=2.03; 95% CI=1.10-3.74), and 1.49 times higher in 60~69 years (OR=1.07; 95% CI=1.04-2.76). Conclusions: This study found that periodontal disease and tooth loss in Korean adults aged 40 and older was significantly associated with high-sensitivity C-reactive protein.

• Annals of Clinical Neurophysiology
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• 제16권2호
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• pp.55-61
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• 2014

Background: Viruses can cause either meningitis or encephalitis. It is unclear why some people suffer from aseptic meningitis, and others acquire aseptic encephalitis when infected with the same viral pathogens. The aim of this study was to compare demographic and laboratory factors between patients with aseptic meningitis and encephalitis. Methods: The demographic and laboratory differences were analyzed according to age, sex, diabetes, hypertension, C-reactive protein in the blood, white blood cell and protein in the cerebrospinal fluid, and glucose ratio (cerebrospinal fluid/blood). Additionally, we analyzed the nation-wide differencesin age between the patients with aseptic meningitis and those with encephalitis in Korea. Results: The patients with aseptic encephalitis were older, more likely to have hypertension, and had higher levels of C-reactive protein than did the patients with aseptic meningitis. However, the numbers of white blood cells in the cerebrospinal fluid were significantly higher in the patients with meningitis than in the patients with encephalitis. Multivariable analysis revealed that age >49 years, hypertension and a C-reactive protein level >5.81 mg/dL were independent and significant variables in the prediction of aseptic encephalitis. Additionally, the patients with aseptic encephalitis were older than those with aseptic meningitis in the nation-wide Korean database. Conclusions: Older age, hypertension, and higher levels of C-reactive protein are useful factors for the prediction of aseptic encephalitis.

• Journal of Yeungnam Medical Science
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• 제10권2호
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• pp.298-305
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• 1993

임신주령과 진통 및 분만의 진행정도에 따른 정상 임부의 혈청 CRP치의 동태를 파악하기 위해서 1992년 3월 1일 부터 1993년 8월 31일 까지 18개월간 영남대학교 의과대학 부속병원 산부인과에서 임신 20주에서 44주 사이의 건강한 임부 521명을 대상으로 혈청 CRP치를 측정하여 임신 주령과 진통의 유무, 양막의 파열여부 및 분만의 진행정도에 따라 비교 분석한 결과는 다음과 같다. 1. 혈청 CRP치 0.8mg/dl 이상과 2.0mg/dl 이상을 나타낸 임부의 빈도는 각각 12%(61/521)와 4%(22/521)이었다. 2. 임신주령 37주이하의 만삭전 임부군과 38주 이상의 만삭 임부군, 양막 파열 임부군과 비파열 임부군, 자궁경관 개대 3cm이하 임부군과 4cm 이상 임부군의 비교에서 혈청 CRP치 0.8mg/dl 이상과 2.0mg/dl 이상을 나타낸 임부의 빈도는 통계적으로 유의한 차이가 없었다. 3. 진통이 없는 임부군과 진통중인 임부군의 비교에서 혈청 CRP치 0.8mg/dl 이상을 나타낸 임부의 빈도는 각각 5.93%와 13.73%로 통계적으로 유의한 차이(p<0.05)가 있었으나 혈청 CRP치 2.0mg/dl 이상을 나타낸 임부의 빈도는 차이가 없었다. 4. 임신주령 37주 이하의 만삭전 임부군에서 혈청 CRP치 0.8mg/dl 이상을 나타낸 임부의 빈도는 진통중인 임부군이 23.64%로 진통이 없는 임부군의 4.69% 보다 현저히 높았으며(p<0.001), 혈청 CRP치 2.0mg/dl 이상을 나타낸 임부의 빈도도 진통중인 임부군과 진통이 없는 임부군이 각각 12.73%와 3.13%로 통계적으로 유의성 있는 차이(p<0.05)가 있었다. 임신주령 38주 이상의 만삭 임부군에서 진통이 없는 임부군과 진통중인 임부군을 비교하여 혈청 CRP치 0.8mg/dl 이상과 2.0mg/dl 이상을 나타낸 임부의 빈도는 통계적으로 유의성 있는 차이가 없었다. 이상 본 연구의 결과를 종합하면 임부의 감염을 조기 예측하는데 있어 기왕에 조기진통 임부에서 임상적 감염의 지표로 이용되고 있는 혈청 CRP치 2.0mg/dl은 진통중인 만삭임부에서도 양막파열 여부와 분만의 진행정도와 무관하게 유용한 것으로 추정되며, 조기진통 임부의 처치시 혈청 CRP치가 0.8mg/bl 이상인 경우 임부의 불현성 감염을 의심하여야 할 것으로 생각된다.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 2004년도 제56차 추계 학술대회 연제집
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• pp.50.1-50.1
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• 2004

• Journal of Nutrition and Health
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• 제45권4호
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• pp.303-314
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• 2012

The purpose of this study was to investigate the relationship between dietary fat intake, anthropometric data, blood lipids, C-reactive protein, and adiponectin in Korean male college students. Forty-eight subjects were divided into 2 groups based on dietary fat intake: UERF (under 30% of energy ratio for fat source), AERF (above 30% of energy ratio for fat souce). We collected dietary intake data using 24-hour dietary recall for 3 days. Anthropometric and biochemical parameters were measured by using standard methods. Segmental body composition analysis was carried out using an 8-electrode multifrequency bioelectrical impedance method of body fat estimation. There was no significant difference in anthropometric data and serum lipid profile between UERF and AERF group. Serum C-reactive protein level was significantly higher in the AERF group compared to the UERF group. Although there was no significant difference in serum adiponectin level between UERF and AERF groups, subjects had lower adiponectin levels. Correlation data show that serum adiponectin level was positively correlated with vegetable intake (p < 0.05). In addition, dietary fat intake had a positive correlation with meat (p < 0.01), whereas a negative correlation with grain (p < 0.01), vegetables (p < 0.05), and fish (p < 0.05). These results suggest that the increased fat intake of non-obese Korean male college students is associated with their increased serum C-reactive protein concentration. Therefore, proper guidelines on fat intake and nutrition education are necessary for the prevention and management of metabolic syndromes.

• 산업식품공학
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• 제14권1호
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• pp.21-26
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• 2010

C-Reactive protein (CRP), which is an 118 kDa pentameric protein, was secreted by the liver is an important biomarker for coronary disease, hypertension and inflammation. In this study, a method for CRP detection exploiting quantum dot (Qdot)-antibody conjugate was developed according to an indirect-competitive immunosensing protocol. For this purpose, a streptavidin-bound $Qdot_{605}$ was linked with a separately prepared biotinylated monoclonal antirat CRP antibody to produce a Qdot-antibody conjugate. The immunosensing was performed at 0.1 and 20 nM of the coating antigen and conjugate, respectively. The current method was found very sensitive in CRP detection, judging from the concentration-dependent fluorescence emission.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제29권1호
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• pp.5-13
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• 2003

본 연구의 목적은 두경부 감염 환자에서 적혈구침강속도(ESR), 백혈구와 비교해 혈장 내 C-Reactive Protein(CRP)이 가지는 진단과 경과관찰에서의 기여도를 아는 데 있다. 본 연구를 위해 31명의 감염환자를 실험군으로, 32명의 악교정 수술 환자를 대조군으로 설정하여 다음과 같은 결과를 얻었다. 1. 실험군에서의 C-Reactive Protein(CRP)은 대조군의 CRP에 비해 더 높은 수치를 나타내며 감염이 지속되었던 증례를 제외하고는 지속적으로 감소하는 경향을 나타내었다(P<0.001). 2. ESR은 실험군과 대조군에서 모두 일정한 경향이 없었다. 3. 각 변수간의 상관관계는 CRP와 백혈구가 상관계수 0.664로 가장 높은 양의 상관관계를 나타내었다(r=0.664, P<0.01). 4. 설정된 ROC curve에서 분류기준값(cut-off value)의 변화에 따라 CRP 곡선의 증가가 빠르게 나타나고 측정된 곡선의 아래 면적(AUC: Area Under the Curve)이 0.744로 높은 값을 나타내어 예측의 정확도가 높다고 판단된다. 5. 실험군에서 회복일(recovery day)에 각 변수의 민감도는 CRP가 83%, ESR이 17%, 백혈구가 71%로 나타났다. 이상의 연구로 미루어 볼 때, 두경부 영역에서 CRP는 감염을 진단하고 경과관찰을 하는데 있어 ESR이나 Leukocyte에 비해 더 민감하게 환자를 감시(monitoring)할 수 있는 유용한 검사라고 사료된다.

• 대한임상검사과학회지
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• 제49권1호
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• pp.15-21
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• 2017

C-reactive protein (CRP) levels are not generally associated with viral infections. This study investigated the changes in the CRP level caused by an infection from respiratory virus (RV). Nasopharyngeal samples from hospitalized patients with suspected RV infection were used to measure the CRP levels, virus load, virus-virus co-infection, age, sex, and length of hospital stay (LOS). Abnormal CRP levels were detected in 62.3% (3,608 out of 5,788) of all RV-positive samples. The percentage of patients with abnormal CRP levels tended to increase with age. Furthermore, LOS in patients with abnormal CRP levels was significantly longer than that in patients with normal CRP levels. The frequency of elevated CRP levels differed according to the causative virus and the frequency of abnormal levels increased with age. Moreover, LOS was longer in those with abnormal CRP levels. These data provide important insights into the role of CRP levels in RV infection.

• 성인간호학회지
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• 제18권4호
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• pp.660-667
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• 2006

Purpose: The purpose of this study was to investigate the effects of 12-week brisk walking and brisk walking plus diet program on C-Reactive Protein(CRP) in middle-aged obese hypertriglycemic($triglyceride{\geq}150mg/d{\ell}$) Korean women. Method: The subjects were 16 obese ($BMI{\geq}25$) hypertriglycemic middle-aged women (7 for brisk walking group, 9 for brisk walking plus diet group) who participated in a health promotion program at one public health center. Initially the brisk walking intervention consisted of walking for 20 minutes/day at an intensity of 40 to 50% of heart rate reserve(HRR) for 3 days/week and progressed to 50 minutes/day, 60 to 70% of their HRR, and 6 days/week. The diet intervention consisted of 60 minutes of group education and 20 to 30 minutes of individual counseling with a nutritionist every week. Data were analyzed with SPSS PC program. Results: There was no significant reduction in CRP levels in both brisk walking (Z=-1.70, p=0.088) and brisk walking plus diet group(Z=-0.31, p=0.752). In brisk walking only group, CRP levels were increased after the intervention. Conclusion: Brisk walking could increase the level of CRP when it is in the course of progression and diet could decrease the acute phase inflammatory response.