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Analysis of Fractional Anisotropy Measurements of Diffusion Tensor Images in the Gyrus of the Brain by AUDIT-K Scale

AUDIT-K 척도에 따른 뇌 이랑 부위의 확산텐서 비등방도 측정값 분석

  • 곽종혁 (양산부산대학교병원 영상의학과) ;
  • 김경립 (양산부산대학교병원 감마나이프센터) ;
  • 조희정 (부산과학기술대학교 의무행정과) ;
  • 이은숙 (부산대학교병원 보건의료정보팀) ;
  • 성순기 (양산부산대학교병원 감마나이프센터)
  • Received : 2019.03.27
  • Accepted : 2019.07.13
  • Published : 2019.07.28

Abstract

Diffusion tensor images were obtained for middle-aged men according to the AUDIT-K scale. As a result of the fractional anisotropy (FA) value of the gyrus nerve fibers in the brain region measured and analyzed by the Tract-Based Spatial Statics, FA values of general drinkers were measured lower than those of estimated alcohol use disabled people. This was statistically significant. In other words, the use of alcohol significantly affects the anatomic microstructural changes measured in the Gyrus of the brain region, and it may damage the nerve fiber tract and affect the functional abnormalities associated with it.

AUDIT-K 척도에 따른 중년남성을 대상으로 뇌 회백질의 손상 유무를 파악 할 수 있는 확산텐서영상을 검사하여 영상을 획득 한 후 Tract-Based Spatial Statics(TBSS)방법으로 뇌 회백질 부위의 이랑(Gyrus) 신경 섬유로의 비등방도 FA(fractional anisotropy)값을 측정 분석한 결과 모든 영역에서 정상 음주자가 알코올 사용 장애 추정자보다 FA값이 낮게 측정되었으며 통계적으로 유의하였다. 본 연구의 측정한 FA결과 값으로 추측하자면 즉, 알코올 사용이 뇌 회백질 부위의 이랑(Gyrus) 계측한 해부학적 미세 구조성 변화에 크게 영향을 미치며 신경 섬유로를 손상시키고 이와 관련된 기능적 이상에 영향을 준다고 할 수 있다.

Keywords

CCTHCV_2019_v19n7_176_f0001.png 이미지

Fig. 1. FA value One-Way-ANOVA Box plot with related variables according to AUDIT-K(scale) (N=170)

Table 1. Brain diffusion tensor image paramter

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Table 2. Distribution by sociological characteristics of population

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Table 3. FA value One-Way-ANOVA with related variables according to AUDIT-K(scale)

CCTHCV_2019_v19n7_176_t0003.png 이미지

Table 4. Pearson correlation analysis of Gyrus

CCTHCV_2019_v19n7_176_t0004.png 이미지

Table 5. Multiple regression analysis of OFC(Orbital frontal cortex)

CCTHCV_2019_v19n7_176_t0005.png 이미지

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