Fig. 1. Particle form of micelle and swollen micelle.
Fig. 2. Structure of poloxamer 407 (approximate block lengths of a = 101 and b = 56).
Fig. 3. Manufacturing method of swollen micelle.
Fig. 4. Results of prescription for various solubilizers affecting solubilization in Table 2.
Fig. 5. Results of prescription for changes in content of poloxamer 407 and Octyldodeceth-16 in Table 3.
Fig. 6. Results of tocopheryl acetate solubilization for changes in content of poloxamer 407 and Octyldodeceth-16 in Table 4.
Fig. 7. Box-Behnken design, The point at the center of the cube corresponds to the center of the Box-Behnken design, and the point at the middle of each line of the cube corresponds to the IBFact.
Fig. 8. 3D model for particle size of RSM (A: poloxamer 407, B: octyldodeceth-16, C: tocopheryl acetate / (a): AB, (b): AC, (c): BC).
Fig. 9. 3D model for PDI of RSM (A: poloxamer 407, B: octyldodeceth-16, C: tocopheryl acetate / (d): AB, (e): AC, (f): BC).
Fig. 10. 3D model for Zeta potential of RSM (A: poloxamer 407, B: octyldodeceth-16, C: tocopheryl acetate / (g): AB, (h): AC, (i): BC).
Fig. 11. Stability comparison of swollen micelles after 30 days.
Fig. 12. Turbidity comparison of swollen micelles after 30 days. Rating: 1-10 (the higher the score, the higher the turbidity).
Fig. 13. Cyro-SEM image (left: Run 13 / right: Run 16)
Table 1. Information about the raw materials used in the experiment
Table 2. Prescription experiment for solubilizers affecting solubilization
Table 3. Solubilization prescription experiments on Poloxamer 407 content changes
Table 4. Tocopheryl acetate solubilization experimental prescription
Table 5. Setting and scope of independent variables as RSM factors
Table 6. Experiments on RSM factor range of 17 prescriptions
Table 7. Y-axis variable results for 17 experiments using Box-Behnken design
Table 8. Variance analysis for Y axis variable data
Table 9. Coefficient table to 3D model of variance analysis (A : Poloxamer 407 / B : octyldodeceth-16 / C : tocopheryl acetate)
Table 10. Optimal condition setting using RSM
References
- S. J. Kim, Y. L. Jeong, J. J Nam, J. H. Jang, H. L. Yeo, M. S. Yoon, K. J. Yoo, and J. B Lee, "A study of stabilization for insoluble active ingredients using swollen micelles", J. Soc. Cosmet. Sci. Korea, Vol. 42, No. 1, pp. 9-13, (2016). https://doi.org/10.15230/SCSK.2016.42.1.9
- C. O. Rangel-Yagui, A. Pessoa-Jr, L. C. Tavares, "Micellar solubilization of drugs", J. Pharm. Pharmaceut. Sci., Vol. 8, No. 2, pp. 147-163, (2005).
- M. S. Kim, "A phenomenological study on micellization and solubilization", J. of the Korean Chemical Society, Vol. 33, No. 5, pp. 459-467, (1989).
- S. K. Swafford, W. R. Bergmann, K. G. Migliorese, J. L. Lichtin, A. Sakr, "Characterization of swollen micelles containing linoleic acid in a microemulsion system", J. Soc. Cosmet. Chem., Vol. 42, pp. 235-247, (1991).
- E. Ruckenstein, R. Krishnan, "Swollen micellar models for solubilization", J. of Colloid and Interface Science, Vol. 71, No. 2, pp. 321-335, (1979). https://doi.org/10.1016/0021-9797(79)90243-1
- G. S. Kwon, M. Naito, K. Kataoka, M. Yokoyama, Y. Sakurai, T. Okano, "Block copolymer micelles as vehicles for hydrophobic drugs", Colloids and Surfaces B, Blointerfaces, Vol. 4, No. 2, pp. 429-434, (1994).
- K. Kataoka, A. Harada, Y. Nagasaki, "Block copolymer micelles for drug delivery: design, characterization and biological significance", Advanced Drug Delivery Reviews, Vol. 64, pp. 37-48, (2012). https://doi.org/10.1016/j.addr.2012.09.013
- M. Manik, G. Farid, M. Kruk, "Swollen mixed Pluronic surfactant micelles as templates for mesoporous nanotubes with diverse bridged-organosilica frameworks", J. of Colloid and Interface Science, Vol. 524, pp. 445-455, (2018). https://doi.org/10.1016/j.jcis.2018.04.011
- M. N. Freitas, M. Farah, R. E. S. Bretas, E. Ricci-Junior, J. M. Marchetti, "Rheological characterization of Poloxamer 407 nimesulide gels", J. of Colloid and Interface Science, Vol. 27, No. 1, pp. 113-118, (2006).
- M. Manik, G. Farid, M. Kruk, "Swollen mixed Pluronic surfactant micelles as templates for mesoporous nanotubes with diverse bridged-organosilica frameworks", J. of Colloid and Interface Science, Vol. 524, pp. 445-455, (2018). https://doi.org/10.1016/j.jcis.2018.04.011
- H. Almeida, M. H. Amaral, P. Lobao, J. M. S. Lobo, "Pluronic F-127 and Pluronic lecithin organogel (PLO): main features and their applications in topical and transdermal administration of drugs", J. Pharm. Pharmaceut. Sci., Vol. 15, No. 2, pp. 592-605, (2012). https://doi.org/10.18433/J3HW2B
- H. Alsaab, S. P. Bonam, D. Bahl, P. Chowdhury, K. Alexander, S. HS. Boddu, "Organogels in drug delivery: a special emphasis on organogels Pluronic lecithin", J. Pharm. Pharm. Sci., Vol. 19, No. 2, pp. 252-273, (2016). https://doi.org/10.18433/J3V89W
- J. H. Kim, H. J. Yang, B. R. Won, Y. J. Ahn, M. K. Kang, S. N. Park, "Preparation of vitamin E acetate nano-emulsion and in vitro research regarding vitamin E acetate transdermal delivery system which use Franz diffusion cell", J. Soc. Cosmet. Scientists Korea, Vol. 35, No. 2, pp. 91-101, (2009).
- M. A. Bezerraa, R. E. Santelli, E. P. Oliveiraa, L. S. Villar, L. A. l. Escaleiraa, "Response surface methodology (RSM) as a tool for optimization in analytical chemistry", Talanta, Vol. 76, pp. 965-977, (2008). https://doi.org/10.1016/j.talanta.2008.05.019
- K. Y. Lee, G. S. Choi, T. W. Kim, K. H. Cho, D. J. Kang, S. T. Kim, D. J. Jang, "Modeling and optimization of dough properties using response surface design", Food Eng. Prog., Vol. 21, No. 2, pp. 132-137, (2017). https://doi.org/10.13050/foodengprog.2017.21.2.132
- I. M. Yang, G. T. Oh, C. B. Yu, I. G. Hwang, "Design and analysis of experiments.",, pp. 432-433, Minyoungsa, (2015).
- S. L. C. Ferreira, R. E. Bruns, H. S. Ferreira, G. D. Matos, J. M. David, G. C. Brandᾶo, E. G. P. da Silva, L. A. Portugal, P. S. dos Reis, A. S. Souza, W. N. L. dos Santos, "Box-Behnken design: an alternative for the optimization of analytical methods", Analytica Chimica Acta, Vol. 592, No. 2, pp. 179-186, (2007).
- S. Rane, B. Prabhakar, "Optimization of paclitaxel containing pH-sensitive liposomes by 3 factor, 3 level Box-Behnken design", Indian Journal of Pharmaceutical Sciences, Vol. 75, No. 4, pp. 420-426, (2013). https://doi.org/10.4103/0250-474X.119820