Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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The Effect of Micro-current Electrical Therapy on Muscle Atrophy and Delayed Wound Healing Process Induced Rat Caused by Traumatic Peripheral Nerve Injury

외상성 말초신경 손상으로 인한 창상 치유 지연 및 근위축이 유발된 소동물에서의 미세전류 자극 효능 평가

  • Lee, Hana (Department of Biomedical Engineering, Yonsei University) ;
  • Kim, Seohyun (Department of Biomedical Engineering, Yonsei University) ;
  • Hwang, Donghyun (Department of Biomedical Engineering, Yonsei University) ;
  • Yoo, Lee (Department of Biomedical Engineering, Yonsei University) ;
  • Yu, Jihee (Department of Biomedical Engineering, Yonsei University) ;
  • Kim, Minju (Department of Biomedical Engineering, Yonsei University) ;
  • Cho, Seungkwan (Cellogin Inc.) ;
  • Kim, Han Sung (Department of Biomedical Engineering, Yonsei University)
  • Published : 2018.02.28
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Abstract

This study was carried out to evaluate the effect of micro-current therapy on muscle atrophy and delayed wound healing process caused by traumatic peripheral nerve injury. For this, twenty-five 5-week-old Sprague Dawley rat were used and assigned to five groups including the normal group (NOR, n=5), the wound group (WD, n=5), the wounded and treated with micro-current electrical therapy group (WD+MET, n=5), the sciatic nerve denervated and wounded group (WD+DN, n=5), and the sciatic nerve denervated, wounded and treated with micro-current electrical therapy group (WD+DN+MET, n=5). In order to assess the changes in length of incisional wound for 12 days and the muscle volume for 2 weeks, the ImageJ analysis of macroscopic analysis and micro-CT data were obtained and analyzed. As a result, significant delay in the process in wound healing were observed and micro-current therapy suppress the postponement of healing process. Furthermore, there were significant changes in muscle volume between electrically treated group and non-treated group. These result shows that electrical stimulation may improve the delayed healing process and muscle atrophy at once.

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References

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