KIPS Transactions on Software and Data Engineering (정보처리학회논문지:소프트웨어 및 데이터공학)

Korea Information Processing Society (한국정보처리학회)
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Building an Ontology-Based Diagnosis Process of Crohn's Disease Using the Differentiation Rule

감별 규칙을 이용한 온톨로지 기반 크론병 진단 프로세스 정의

  • Received : 2018.07.06
  • Accepted : 2018.08.03
  • Published : 2018.11.30
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Abstract

Crohn's disease, which is recently increasing in Korea, may be seen throughout the gastrointestinal tract and cause various symptoms. In particular, Crohn's disease is especially difficult to diagnose with several symptoms similar to other ulcerative colonic diseases. Thus, some studies are underway to distinguish two or more similar diseases. However, the previous studies have not described the procedural diagnosis process of it, which may lead to over-examination in the process. Therefore, we propose a diagnosis process of Crohn's disease based on the analysis of redundancy, sequential linkage and decision point in the diagnosis of Crohn's disease, so that it enables to identify ulcerative colonic diseases with symptoms similar to Crohn's disease. Finally, we can distinguish the colon diseases that have symptoms similar to Crohn's disease and help diagnose Crohn's disease effectively by defining the proposed process-oriented association as an ontology. Applying the proposed ontology to 5 cases showed that more accurate diagnosis was possible and in one case it could be diagnosed even with fewer tests.

최근 국내에서도 발병률이 증가하고 있는 크론병은 위장관의 모든 부위에서 발병할 수 있으며, 나타나는 증상도 다양하다. 특히, 크론병은 다른 궤양성 대장질환과 유사한 증상을 보일 수 있어 크론병을 진단하는데 어려움을 겪는다. 이로 인해 크론병 진단 가이드라인이나 크론병과 유사한 증상을 보이는 질병의 감별에 대한 연구가 진행되고 있다. 하지만 기존 연구에는 크론병에 대한 순차적인 진단 과정이 기술되지 않아, 크론병 진단을 위한 검사 과정에서 과다한 검사가 시행될 우려가 있다. 따라서 본 논문에서는 크론병과 유사한 증상을 보이는 궤양성 대장 질환을 감별하기 위해 중복성 및 순차적인 연관성, 질병의 진단 조건을 분석하여 감별 규칙으로 정의하고, 이를 기반으로 크론병 진단 프로세스를 제안한다. 또한, 제안하는 프로세스 중심의 연관성을 온톨로지로 정의함으로써 크론병과 유사한 증상을 보이는 대장 질환을 감별하고, 효과적으로 크론병을 진단하는데 도움을 줄 수 있다. 제안한 온톨로지를 5개의 사례에 적용해 본 결과, 모두 올바른 진단을 내렸으며 1개의 사례에서 더 적은 수의 검사로 진단할 수 있었다.

Keywords

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Fig. 1. Sites that Commonly Cause Crohn's Disease in the Large Intestine

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Fig. 2. Colonic Disease Diagnosed by Ulcer

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Fig. 3. Procedural Relationship of Examinations for Diagnosis of Crohn’s Disease

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Fig. 4. A Diagnosis Process of Crohn's Disease

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Fig. 5. Visualization of Crohn's Disease Ontology for Ulcer

Table 1. Examples of Differentiation Rules for Ulcerative Colitis Disease

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Table 2. Decision Conditions using the Differential Diagnosis of Crohn's Disease

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Table 3. Crohn's Disease Diagnosis Ontology Test Case

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References

  1. Health Insurance Review&Assessment Service, Crohn's Disease[Internet], https://www.hira.or.kr/re/stcIlnsInfm/stcIl nsInfmView.do?pgmid=HIRAA030502000000&sortSno=183.
  2. Y. S. Park, "Colon Disease that is Difficult to Differentiate," The Korean Journal of Gastrointestinal Endoscopy, Vol.34, No.1, pp.51-55, 2007.
  3. B. D. Ye, B. I. Jang, Y. T. Jeen, K. M. Lee, J. S. Kim, S. K. Yang, and IBD Study Group of the Korean Association of the Study of Intestinal Diseases, "Diagnostic Guideline of Crohn's Disease," The Korean Journal of Gastroenterology, Vol.53, No.3, pp.161-176, 2009.
  4. S. S. A. Naser and S. H. ALmursheidi, "A Knowledge Based System for Neck Pain Diagnosis," World Wide Journal of Multidisciplinary Research and Development (WWJMRD), Vol.2, No.4, pp.12-18, 2016.
  5. S. S. A. Naser and M. A. Al-Nakhal, "A Ruled Based System for Ear Problem Diagnosis and Treatment," World Wide Journal of Multidisciplinary Research and Development, Vol.2. No.4, pp.25-31, 2016.
  6. T. Ivascu, B. Manate, and V. Negru, "A multi-agent architecture for ontology-based diagnosis of mental disorders," in Symbolic and Numeric Algorithms for Scientific Computing (SYNASC), 2015 17th International Symposium on. IEEE, pp.423-430, 2015.
  7. M. P. Brundage, B. Kulvatunyou, T. Ademujimi, and B. Rakshith, "Smart manufacturing through a framework for a knowledge-based diagnosis system," ASME 2017 12th International Manufacturing Science and Engineering Conference Collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing, American Society of Mechanical Engineers, Vol.3, pp.V003T04A012; 9 pages, 2017.
  8. J. H. Kang and S. I. Choi, "Additional One Case of Crohn's Disease," Annual Congress of KSS 1998 50th Annual Congress of the Korean Surgical Society, pp.567-567, 1998.
  9. K. Y. Kim, H. J. Kim, J. Y. Jang, K. C. Lee, S. H. Jung, S. H. Dong, B. H. Kim, Y. W. Chang, and Rin Chang, "A Case of Granulomatous Liver Disease Combined with Crohn's Disease," The Korean Journal of Gastrointestinal Endoscopy, Vol.36, No.5, pp.298-301, 2008.
  10. S. M. Jung, C. H. Choi, H. R. Seol, S. J. Jung, S. J. Hwang, H. W. Lee, H. J. Kim, J. H. Do, and S. K. Jang, "Two Cases of Familial Crohn's Disease in Parents, Children, and Siblings," The Korean Journal of Medicine, Vol.75, No.s1, pp.388-388, 2008.
  11. D. J. Song, S. I. Hwang, H. W. Choi, and C. Y. Jung, "A Case of Crohn's Disease Limited to the Duodenum," The Korean Journal of Medicine, Vol.89, No.cho1, pp.54-54, 2015. https://doi.org/10.3904/kjm.2015.89.1.54
  12. B. S. Cho, S. K. Kwok, Y. I. Seo, D. J. Min, W. U. Kim, S. K. Lee, S. H. Park, C. S. Cho, and H. Y. Kim, "A Case of Rheumatoid Arthritis Associated with Ulcerative Colitis," The Journal of Rheumatic Diseases, Vol.8, No.4, pp.262-267, 2001.