Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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Evaluation of Efficacy of Aconitum carmichaeli Debx Extract on Obesity and Glucose Tolerance in Diet Induced Obese Mice

고지방식이로 유도된 비만형 동물모델에서 부자 물추출물의 비만 및 당대사 개선 효능 평가

  • Song, Mi-Young (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University)
  • 송미영 (동국대학교 한의과대학 한방재활의학교실)
  • Received : 2017.05.09
  • Accepted : 2017.06.07
  • Published : 2017.06.30
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Abstract

Objectives: This study investigated the effects of water extract of Aconitum carmichaeli Debx (ACD) on obesity and glucose tolerance in high fat diet induced obese mice. Methods: Five-week-old C5BL/6 mice were fed a high fat diet (HFD) containing or not containing ACD (100 or 300 mg/kg) for 16 weeks. Body weight, food intake, fasting blood glucose, and body temperature were checked every week and then organs, blood serums were collected after 16-week treatment. Furthermore oral glucose tolerance test (OGTT) was carried out after treatment. Results: ACD treated mice showed no significant decreases in body weight and adipose tissue weight as compared with HFD mice. Lipid accumulations in liver and serum lipid levels were not different between ACD treated and HFD mice. However, ACD extract administration significantly and dose-dependently reduced fasted plasma glucose and glucose tolerance as determined by OGTT. Conclusions: The present study demonstrates that ACD might prevent diet-induced glucose tolerance in mouse models of obesity.

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References

  1. Moon JS, Kang BG, Ryu EK, Choi SM. A study of syndrome of index differentiation in obesity. J Korean Med Obes Res. 2007 ; 7(1) : 55-69.
  2. Kim SJ, Shin SW, Kim HJ. Obesity from the view point of metabolic rate. J Korean Med Obes Res. 2003 : 3(1) : 95-105.
  3. Tseng YH, Cypess AM, Kahn CR. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov. 2010 ; 9(6) : 465-82. https://doi.org/10.1038/nrd3138
  4. Wallace DC. Mitochondria as Chi. Genetics. 2008 ; 179(2) : 727-35. https://doi.org/10.1534/genetics.104.91769
  5. Bae BC. Basic Korean medicine. Seoul : Seongbosa. 1997 : 385-416.
  6. Song MY. The effects of Cinnamomum cassia Blume, Aconitum carmichaeli Debx, and Pueraria lobata Benth on glucose and energy metabolism in C2C12 myotubes. J Korean Med Obes Res. 2015 ; 15(2) : 131-6. https://doi.org/10.15429/jkomor.2015.15.2.131
  7. Song MY. The effects of Astragali radix extracts on mitochondrial function in C2C12 myotubes. J Korean Med Obes Res. 2014 ; 14(2) : 55-62. https://doi.org/10.15429/jkomor.2014.14.2.55
  8. Song MY, Kang SY, Oh TW, Kumar RV, Jung HW, Park YK: The roots of Atractylodes macrocephala Koidzumi enhanced glucose and lipid Metabolism in C2C12 myotubes via mitochondrial regulation. Evid Based Complement Alternat Med. 2015 ; 2015 : 643654.
  9. The National College of Korean Medicine of Herbology. Herbology. Seoul : Youngrimsa. 2016 : 372-74.
  10. Kang BK, Kim EK, Kim IS, Hwang TO, Lee SW, Lee SK, et al. Effects of buja.padu.daehwang.seokgo extract on UCPs expression in mice. Korean J Orient Physiol Pathol. 2007 ; 21(6) : 1407-10.
  11. Song MY. Effect of Aconitum carmichaeli Debx on energy metabolism in C2C12 skeletal muscle cells. J Korean Med Obes Res. 2016 ; 16(2) : 109-15. https://doi.org/10.15429/jkomor.2016.16.2.109
  12. Jung HS, Song BY, Lee CH, Yook TH. effects of cinnamomum cassia and aconitum carmichaeli's pharmacopuncture and oral administration on blood sugar in type II diabetic mice. Acupuncture. 2010 ; 27(5) : 1-12.
  13. Song MY. The study of the changes of obesity-relating biomarkers in high fat fed-induced C57BL/6 mice. J Korean Med Obes Res. 2016 ; 16(1) : 19-26. https://doi.org/10.15429/jkomor.2016.16.1.19
  14. Song MY. Antiobesity effect of water extract of Coix lacrymajobi var. mayuen in high fat fed C5BL/6 mice. J Korean Med Obes Res. 2016 ; 16(1) : 27-35. https://doi.org/10.15429/jkomor.2016.16.1.27
  15. Jung HW, Kang AN, Kang SY, Park YK, Song MY. The root extract of pueraria lobata and its main compound, puerarin, prevent obesity by increasing the energy metabolism in skeletal muscle. Nutrients. 2017 ; 9 : 33. https://doi.org/10.3390/nu9010033
  16. Sishi B, Loos B, Ellis B, Smith W, du Toit EF, Engelbrecht AM. Diet-induced obesity alters signalling pathways and induces atrophy and apoptosis in skeletal muscle in a prediabetic rat model. Exp Physiol. 2011 ; 96(2) : 179-93. https://doi.org/10.1113/expphysiol.2010.054189
  17. Pompeani N, Rybalka E, Latchman H, Murphy RM, Croft K, Hayes A. Skeletal muscle atrophy in sedentary Zucker obese rats is not caused by calpain-mediated muscle damage or lipid peroxidation induced by oxidative stress. J Negat Results Biomed. 2014 ; 13 : 19. https://doi.org/10.1186/s12952-014-0019-z
  18. Aguiar AF, de Souza RW, Aguiar DH, Aguiar RC, Vechetti IJ Jr, Dal-Pai-Silva M. Creatine does not promote hypertrophy in skeletal muscle in supplemented compared with nonsupplemented rats subjected to a similar workload. Nutr Res. 2011 ; 31(8) : 652-7. https://doi.org/10.1016/j.nutres.2011.08.006
  19. Nagai M, Komiya H, Mori Y, Ohtaz T, Kasahara Y, Ikeda Y. Estimating visceral fat area by multifrequency bioelectrical impedance. Diabetes Care. 2010 ; 33(5) : 1077-9. https://doi.org/10.2337/dc09-1099
  20. Hwang MS, Hwang JY, Kang SY, Kang AN, Roh HS, Park YK. Effects study of Aconiti Lateralis Radix Preparata extract on the regulation of heat and cold in PTU-induced hypothyroidism rats. Korean J Herbol. 2016 ; 31(6) : 63-71.
  21. Williams LM, Campbell FM, Drew JE, Koch C, Hoggard N, Rees WD, et al. The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases. PLoS One. 2014 ; 9(8) : e106159. https://doi.org/10.1371/journal.pone.0106159
  22. Kim DY, Kim MS, Sa BK, Kim MB, Hwang JK. Boesenbergia pandurata attenuates diet-induced obesity by activating AMP-activated protein kinase and regulating lipid metabolism. Int J Mol Sci. 2012 ; 13(1) : 994-1005. https://doi.org/10.3390/ijms13010994
  23. Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest. 2000 ; 106(4) : 473-81. https://doi.org/10.1172/JCI10842
  24. Landsberg L, Young JB, Leonard WR, Linsenmeier RA, Turek FW. Is obesity associated with lower body temperatures? Core temperature: a forgotten variable in energy balance. Metabolism. 2009 ; 58(6) : 871-6. https://doi.org/10.1016/j.metabol.2009.02.017
  25. Jurgens HS, Schurmann A, Kluge R, Ortmann S, Klaus S, Joost HG, et al. Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice. Physiol Genom. 2006 ; 25(2) : 234-41. https://doi.org/10.1152/physiolgenomics.00252.2005
  26. Heikens MJ, Gorbach AM, Eden HS, Savastano DM, Chen KY, Skarulis MC, et al. Core body temperature in obesity. Am J Clin Nutr. 2011 ; 93(5) : 963-7. https://doi.org/10.3945/ajcn.110.006270

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