Mass Spectrometry Letters

Korean Society for Mass Spectrometry (한국질량분석학회)
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Basics of Ion Mobility Mass Spectrometry

  • Lee, Jong Wha (Center for Analytical Chemistry, Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science (KRISS))
  • Received : 2017.11.29
  • Accepted : 2017.12.19
  • Published : 2017.12.30
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Abstract

Ion mobility mass spectrometry (IM-MS) combines the advantages of ion mobility spectrometry (IMS) and MS for effective gas-phase ion analysis. Separation of ions based on their mobilities prior to MS can be performed without a great loss in other analytical figures of merit, and the extra dimension of analysis offered by IM can be beneficial for isomer and complex sample analyses. In this review, basic principles of IMS and IM-MS are described in addition to an introduction to various IMS techniques and commercial IM-MS instruments. The nature of collision cross-section (${\Omega}_D$), an important parameter determining the transport properties of ions in IMS, is also explained in detail.

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