Mass Spectrometry Letters

Korean Society for Mass Spectrometry (한국질량분석학회)
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MS-Based Technologies for the Study of Site-Specific Glycosylation

  • Kim, Unyong (Graduate School of Analytical Science and Technology, Chungnam National University) ;
  • Oh, Myung Jin (Graduate School of Analytical Science and Technology, Chungnam National University) ;
  • Lee, Jua (Graduate School of Analytical Science and Technology, Chungnam National University) ;
  • Hwang, Hee Yeon (Graduate School of Analytical Science and Technology, Chungnam National University) ;
  • An, Hyun Joo (Graduate School of Analytical Science and Technology, Chungnam National University)
  • Received : 2017.11.17
  • Accepted : 2017.12.18
  • Published : 2017.12.30
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Abstract

Glycosylation, which is one of the most common post-translation modification (PTMs) of proteins, plays a variety of crucial roles in many cellular events and biotherapeutics. Recent advances have led to the development of various analytical methods employing a mass spectrometry for glycomic and glycoproteomic study. However, site-specific glycosylation analysis is still a relatively new area with high potential for technologies and method development. This review will cover current MS-based workflows and technologies for site-specific mapping of glycosylation ranging from glycopeptide preparation to MS analysis. Bioinformatic tools for comprehensive analysis of glycoprotein with high-throughput manner will be also included.

Keywords

References

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