Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Skin Hydration Effect of Jeju Lava Sea Water

제주용암해수의 피부 보습 효과 연구

  • 이성훈 ((주)아모레퍼시픽 기술연구원) ;
  • 배일홍 ((주)아모레퍼시픽 기술연구원) ;
  • 민대진 ((주)아모레퍼시픽 기술연구원) ;
  • 김형준 ((주)아모레퍼시픽 기술연구원) ;
  • 박녹현 ((주)아모레퍼시픽 기술연구원) ;
  • 최지예 ((주)아모레퍼시픽 기술연구원) ;
  • 신진섭 ((주)아모레퍼시픽 기술연구원) ;
  • 김은주 ((주)아모레퍼시픽 기술연구원) ;
  • 이해광 ((주)아모레퍼시픽 기술연구원)
  • Received : 2016.09.12
  • Accepted : 2016.12.19
  • Published : 2016.12.30
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Abstract

Many minerals and nutrient salts are abundant in Jeju lava sea water. The objective of this study was to evaluate the skin hydration effects of Jeju lava sea water. The skin barrier serves as a protective barrier that prevents the loss of moisture. The water holding capacity and water transport of the epidermis have been proposed to be important determinants of skin hydration. Jeju lava sea water increased the mRNA expression of filaggrin and caspase-14 which is related to natural moisturizing factor (NMF) formation. Aquaporins 3 (AQP3) are proteins that facilitate the transport of water across cell membranes. Jeju lava sea water increased the mRNA expression and protein expression of AQP3. We employed a skin equivalent model to assess the efficacy of Jeju lava sea water. In a skin equivalent model, Jeju lava sea water increased the CD44 (hyaluronic acid receptor) which is related to skin hydration. From these results, we found out Jeju lava sea water maybe help to skin hydration.

제주용암해수는 미네랄과 영양염류가 풍부한 물로 제주만이 보유한 지하수자원이다. 본 연구의 목적은 제주용암해수의 피부 보습효과를 확인하기 위한 것이다. 피부의 건조함을 막고 수분을 유지하기 위해서는 표피층의 장벽기능이 정상적으로 기능하고, 표피층 내 수분의 유지와 이동이 원활히 이루어져야 한다. 제주용암해수를 각질형성세포에 처리한 결과 표피층의 분화과정과 natural moisturizing factor (NMF) 생성과정에 관여하는 유전자인 필라그린과 caspase-14 유전자의 발현양이 증가되는 것을 확인할 수 있었다. 또한 막관통 단백질로 수분의 이동을 조절하는 aquaporin 3 (AQP3) 유전자 발현양과 단백질 발현양도 제주용암해수 처리에 의해 증가하였다. 인공피부를 이용한 실험에서 제주용암해수를 배지에 처리하고 배양한 결과 hyaluronic acid (HA)의 수용체인 CD44의 발현양이 증가하였다. 본 연구를 통해 제주용암해수는 피부 보습과 관련된 인자들의 발현양을 증가시켜 피부의 보습기능에 도움을 주는 것으로 사료되었다.

Keywords

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