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Correlation of Urinary Hippuric Acid Concentration according to Occupational Exposure Level of Toluene and Worker's Characteristics

작업환경중 톨루엔 농도와 근로자 특성에 따른 뇨중 마뇨산 농도의 상관성

  • Lee, Gye-Young (Department of Environmental Engineering, Chungbuk National University) ;
  • Shin, Taek-Soo (Department of Environmental Engineering, Chungbuk National University) ;
  • Hong, Sang-Pyo (Department of Environmental Engineering, Cheongju University) ;
  • Kim, Kwangyul (Department of Environmental Engineering, Chungbuk National University)
  • Received : 2014.09.16
  • Accepted : 2015.03.20
  • Published : 2015.04.30

Abstract

Correlation between occupational exposure levels to toluene and urinary hippuric acid (HA) concentrations were studied for 124 workers at 54 work places. The highest indoor toluene concentration measured at printing process was 81.116 ppm, and their geometric average concentration was as high as 12.304 ppm. The geometric average concentration of hippuric acid in urine samples from workers who are exposed to toluene was 0.714 g/g creatinine. This is almost five times higher than the average HA concentration from non-exposure workers. Printing workers showed the average HA concentration of 1.145 g/g creatinine from their urine samples. It is the highest concentration among the workers exposed to toluene. The correlation coefficient between HA concentrations in urine and indoor toluene concentration at work places was relatively high as r=0.624 (P<0.01). But the correlations of HA with sex, smoking, drinking, age and employment history was relatively low. We can express the regression equation for the urinary HA concentration which is Y = 0.037X + 0.562 as exposure toluene concentration is X. The urinary HA concentrations showed significantly increase depend on indoor toluene concentration at work place.

작업환경중 톨루엔 농도와 뇨중 마뇨산 농도와의 상관성에 대하여 54개 사업장에서 일하는 124명의 근로자를 대상으로 연구하였다. 가장 높은 실내 작업장의 톨루엔 농도는 인쇄 공정에서 81.116ppm으로 측정되었으며, 기하평균농도는 12.304 ppm으로 높은 값을 나타내었다. 톨루엔 노출 작업자의 뇨중 마뇨산 농도의 기하평균은 0.714 g/g creatinine으로, 비노출군에 비하여 5배 정도 높게 나타났다. 인쇄 공정 노동자의 평균 뇨중 마뇨산 농도는 다른 공정의 노동자에 비해 가장 높은 1.145g/g creatinine 이었다. 작업자의 노출 톨루엔 농도와 뇨중 마뇨산 농도 사이의 상관계수는 r=0.624 (P<0.01)로 상관성이 비교적 높은 것으로 나타났으나, 뇨중 마뇨산 농도와 근로자의 성별, 음주 및 흡연, 근무경력 등의 상관성은 낮게 나타났다. 노출 톨루엔 농도 X에 대한 뇨중 마뇨산 농도 Y의 회귀방정식은 Y = 0.037X + 0.562로 표현할 수 있다. 결론적으로 작업장에서의 톨루엔 노출농도에 따라 뇨중 마뇨산농도가 유의하게 증가함을 알 수 있다.

Keywords

References

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