부신질환을 지닌 애완 페렛 48마리의 임상적 결과

Clinical Outcomes of 48 Pet Ferrets with Adrenal Disease

  • Jung, Ji-Won (Woosung Animal Medical Center) ;
  • Choi, Young-Min (Woosung Animal Medical Center) ;
  • Yoon, Hun-Young (Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University) ;
  • Jeong, Soon-Wuk (Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University)
  • 심사 : 2014.09.29
  • 발행 : 2014.10.31

초록

애완 페렛의 부신질환은 우리 나라에서도 많이 접하게 되는 질병이다. 하지만 아직 페렛의 부신질환에 대한 연구가 우리나라에서는 이뤄지지 않고 그 실태 보고도 없는 상태이다. 그러므로 본 연구는 부신절제술을 실시한 48마리의 페렛을 대상으로 국내 애완 페렛의 부신질환 발생상황을 알아보고자 하였다. 부신 질환이 있는 애완 페렛은 주로 3~5년령에 다발하였으며, 중성화한 암컷에서 58.3%의 높은 발생을 보였다. 부신질환은 왼쪽 부신 72.9%, 오른쪽 부신 10.4%, 양쪽 부신에 16.7% 있었으며, 초음파상에서 부신크기(길이 *두께)는 왼쪽 부신 8.96 * 5.08 mm, 오른쪽 부신 12.91 * 8.26 mm 로 나타났다. Alopecia가 82.2%로 주요 임상증상이었고 vulvar swelling은 암컷중 32.1%에서 나타났으며, 주된 병발질환으로 renal cyst 29.2%, splenomegaly 25%를 보였다. 조직학적 소견에서 pheochromocytoma, adenoma, hyperplasia 가 각각 44.7%, 14.9%, 12.8% 이었다. 수술후 생존률은 1년과 2년에서 각각 87.5%, 74.0% 였으며, alopecia 및 vulvar swelling은 각각 수술후 평균 3.4개월 및 평균 12일경에 개선되었다.

Medical records of 48 pet ferrets that underwent adrenalectomy were retrospectively reviewed to investigate the frequency and clinical outcomes of adrenal diseases in pet ferrets. These diseases were most commonly diagnosed in ferrets aged 3 to 5 years and in neutered females (58.3%). Adrenal disease occurred most frequently in the left adrenal gland (72.9%), followed by involvement of both adrenal glands (16.7%) and the right adrenal gland (10.4%). The mean sizes (length * thickness) of the adrenal glands as determined by ultrasonography were 8.96 * 5.08 mm and 12.91 * 8.26 mm for the left and right adrenal glands, respectively. In the ferrets with adrenal disease, alopecia (82.2%) was the main presenting clinical signs in both sexes, and vulvar swelling was seen in 32.1% of the females with adrenal disease. The common incidental findings included renal cysts (29.2%) and splenomegaly (25.0%). Histological findings showed pheochromocytoma, adenoma, and hyperplasia in 44.7%, 14.9%, and 12.8% of cases, respectively. The survival rates at 1- and 2- years after surgery were 87.5% and 74.0%, respectively. Alopecia and vulvar swelling improved within an average of 3.4 months and 12 days after surgery.

키워드

참고문헌

  1. Bailey DB, Page RL. Tumors of Endocrine System. In: Small Animal Clinical Oncology. 4th ed. St. Louis: Saunders. 2007: 589-590.
  2. Bartlett LW. Ferret soft tissue surgery. Sem Avn Exo Med 2002; 11; 221-230. https://doi.org/10.1053/saep.2002.126572
  3. Beeber N. Surgical management of adrenal tumors and insulinomas in ferrets, J Exo Med 2011; 20: 206-216. https://doi.org/10.1053/j.jepm.2011.04.006
  4. Besso JG, Tidwell AS, Gliatto JM. Retrospective review of the ultrasonographic features of adrenal lesions in 21 ferrets. Vet Radiol Ultrasound 2000; 41: 345-352. https://doi.org/10.1111/j.1740-8261.2000.tb02086.x
  5. Eatwell K, Two unusual tumors in a ferret (Mustela putorius furo). J Small Anim Pract 2004; 45: 454-459. https://doi.org/10.1111/j.1748-5827.2004.tb00264.x
  6. Miwa Y, Kurosawa A, Ogawa H, Nakayama H, Sasai H. Neoplasitic diseases in ferrets in Japan : a questionnaire study for 2000 to 2005. J Vet Med Sci 2009; 71: 397-402. https://doi.org/10.1292/jvms.71.397
  7. Miwa Y, Nakata M, Kurosawa A, Sasai H, Ssaski N. Adrenal diseases in ferrets in Japan. J Vet Med Sci 2008; 70: 1323-1326. https://doi.org/10.1292/jvms.70.1323
  8. Neuwirth L, Isaza R, Bellah J. Adrenal neoplasia in seven ferrets, Vet Radiol Ultrasound 1993; 34: 340-346. https://doi.org/10.1111/j.1740-8261.1993.tb02017.x
  9. Rosenthal KL, Wyre NR. Endocrine diseases. In: Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. 2nd ed. St. Louis: Saunders. 2012: 86-91
  10. Shoemaker NJ, Ferrets: endocrine and neoplastic diseases. In: BSAVA Manual of Rodents and Ferrets. Gloucester: BSAVA. 2009: 320-324.
  11. Shoemaker NJ, Schuurmans M, Moorman H, Lumeij JT. Correlation between age at neutering and age at onset of hyperadrenocorticism in ferrets. J Am Vet Med Assoc 2000; 216: 195-197. https://doi.org/10.2460/javma.2000.216.195
  12. Shoemaker NJ, Voorhout G. Ultrasonographic visualization of the adrenal glands of healthy ferrets and ferrets with hyperadrenocorticism. J Am Anim Hosp Assoc 2007; 43: 78-84. https://doi.org/10.5326/0430078
  13. Swiderski K, Seim H, MacPhail C. Long term outcome of domestic ferrets treated surgically for hyperadrenocorticism: 130 cases (1995-2004). J Am Vet Med Assoc 2008; 232: 1338-1343. https://doi.org/10.2460/javma.232.9.1338
  14. Wolf TM. Ferrets. In: Manual of Exotic Pet Practice. St. Louis: Saunders. 2009: 362-364.