Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Facile Synthesis of Mollugin by Kinetic Control and anti-HCV (Hepatitis C Virus) Activity of Its Analogues

  • Choi, Da Hye (Department of Chemistry and Institute of Applied Chemistry, Hallym University) ;
  • Lee, Na Ri (Department of Chemistry and Institute of Applied Chemistry, Hallym University) ;
  • Kim, Cheol Gi (Department of Chemistry and Institute of Applied Chemistry, Hallym University) ;
  • Kim, Jong Woo (Advanced Institutes of Convergence Technology, B&C Biopharm Co. Ltd.) ;
  • Lee, Sang Wook (Advanced Institutes of Convergence Technology, B&C Biopharm Co. Ltd.) ;
  • Jun, Jong-Gab (Department of Chemistry and Institute of Applied Chemistry, Hallym University)
  • Received : 2014.05.08
  • Accepted : 2014.07.15
  • Published : 2014.11.20
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Abstract

Mollugin has been reported to have various biological activities including antineoplastic, antitumor, antiviral against the hepatitis B virus, anti-aging and antimutagenic activities. An effective and concise synthesis of mollugin in two steps including kinetic control from the cheap starting material 1,4-naphthoquinone has been introduced, and mollugin derivatives thus prepared are screened for their inhibition ability against the hepatitis C virus (HCV) and the dihydrobenzochromene structure might be an additional anti-HCV agent as a new leading compound.

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References

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