Biomaterials and Biomechanics in Bioengineering

  • 제1권2호
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  • Pages.63-71
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  • 2014
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  • 2465-9835(pISSN)
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  • 2465-9959(eISSN)
테크노프레스 (Techno-Press)
권호 표지
DOI QR코드

DOI QR Code

Synthesis and characterization of silk fibroin-bioactive glass hybrid xerogels

  • Wu, Xiaohong (School and Hospital of Stomatology, Fujian Medical University) ;
  • Yan, Fuhua (Institute and Hospital of Stomatology, Nanjing University Medical School) ;
  • Liu, Wei (College of Materials Science and Engineering, Fuzhou University) ;
  • Zhan, Hongbing (College of Materials Science and Engineering, Fuzhou University) ;
  • Yang, Wenrong (School of Life and Environmental Science, Waurn Ponds Campus, Geelong Deakin University)
  • 투고 : 2013.11.29
  • 심사 : 2014.04.04
  • 발행 : 2014.06.25
⟨ 이전 논문 다음 논문 ⟩

초록

This study aimed to develop a novel bioactive hybrid xerogel consisting of silk fibroin /$SiO_2-CaO-P_2O_5$ by sol-gel process at room temperature. Scanning electron microscopy (SEM), FT-IR Spectroscopy, pore measurement, mechanical property testing, in vitro bioactivity test and cytotoxicity assay were performed to characterize the xerogel for bone tissue engineering application. We have found that the xerogel possessed excellent pore structures and mechanical property. Once immersed in a simulated fluid (SBF), the xerogel exhibited profound bioactivity by inducing hydroxyapatite layers on its surfaces. The cell toxicity study also demonstrated that there was little toxic to MC3T3-E1 cells. These results indicate that silk fibroin /$SiO_2-CaO-P_2O_5$ hybrid xerogel potentially could be used as a bone tissue engineering material.

키워드

과제정보

연구 과제 주관 기관 : Nanjing University Medical School

참고문헌

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