This paper investigated vibrational behavior of the osteon as bone unit in the different situations. This study can lead to increase our knowledge of our body. In this paper free vibration of the osteon with considering it as composite material has been studied. The effect of numbers of lamellae and radius of those on natural frequency of osteon are subtle; while thickness of lamellae have decreasing trend on natural frequency of osteon. The presence of nerve and blood in haversian canal change trend of natural frequency, absolutely. Using the nonlocal strain gradient theory(NSGT) leads to effectiveness of scale parameter on equations of motion and the obtained results. The governing equations are derived by Hamilton's principles. A parametric study is presented to examine the effect of various parameters on vibrational behaviour of osteon. The results can also be regarded as a benchmark in vibration analysis behavior of osteon as bone unite.

Total hip prosthesis is used for the patients who have hip fracture and are unable to recover naturally. To de-sign highly durable prostheses one has to take into account the natural processes occurring in the bone. Finite element analysis is a computer based numerical analysis method which can be used to calculate the response of a model to a set of well-defined boundary conditions. In this paper, the static load analysis is based, by se-lecting the peak load during the stumbling activity. Two different implant materials have been selected to study appropriate material. The results showed the difference of maximum von Misses stress and detected the frac-ture of the femur shaft for different model (Charnley and Osteal) implant with the extended finite element method (XFEM), and after the results of the numerical simulation of XFEM for different was used in deter-mining the stress intensity factors (SIF) to identify the crack behavior implant materials for different crack length. It has been shown that the maximum stress intensity factors were observed in the model of Charnley.

We carry the knowledge that the skeleton bones of the human body are not always without defects and some various defects could occur in them. In the present paper, as the first endeavor, free vibration and buckling analysis of femur bones with femoral defects are investigated. A major strength of this study is the modeling of defects in femur bones. Materialise Mimics software is adopted to model the bone geometry and the SOLIDWORKS software is used to generate the defects in bones. Next, the ABAQUS software is employed to study the behaviors of bones with defects.

Development of lightweight implant plates are important to reduce the stress shielding effect for a prosthesis of femur bone fractures. Stainless steel (SS-316L) is a widely used material for making implants. Stress shielding effect and other issues arise due to the difference in mechanical properties of stainless steel when compared with bone. To overcome these issues, composite materials seem to be a better alternative solution. The comparison is made between two biocompatible composite materials, namely Ti-hydroxyapatite and Ti-polypropylene. "Titanium (Ti)" is fiber material while "hydroxyapatite" and "polypropylene" are matrix materials. These two composites have Young's modulus closer to the bone than stainless steel. Besides the variety of bones, present paper constrained to femur bone analysis only. Being heaviest and longest, the femur is the most likely to fail among all bone failures in human. Modelling of the femur bone, screws, implant and assembly was carried out using CATIA and static analysis was carried out using ANSYS. The femur bone assembly was analyzed for forces during daily activities. Ti-hydroxyapatite and Ti-polypropylene composite implants induced more stress in composite implant plate, results less stress induced in bone leading to a reduction in shielding effect than stainless steel implant plate thus ensuring safety and quick healing for the patient.

In this study, the mathematical model that describes blood cell development in the bone marrow (i.e., hematopoiesis) has been studied via the Homotopy Perturbation Method (HPM). The results from the present work compared very well with the numerical solutions from published literature. This work has shown that the HPM is viable for solving delay differential equations born from hematopoiesis problem. The influence of the proliferating cells loss rate, time delay rate and the phase re-entry rate on the population densities of both the proliferating and resting cells were also determined through the underlined procedure.

As conventional drug delivery system is being improved rapidly by target-based drug delivery system, finding suitable Drug Delivery System (DDS) for new drugs remains a challenge. Although there are many drug delivery vehicles in existence, a significant improvement is required to some DDS such as for local, implant-based treatments used for musculoskeletal infections. Many polymers have been considered for providing the improvement in DDS. Synthetic polymer, for example, has gained popularity for broad-spectrum physicochemical and mechanical properties. This article reviews the biomedical applications of Poly(TriMethylene Carbonate-co-Caprolactone) (PTMCC), which has attracted attention due to its biocompatibility, biodegradability and rubber-like properties. Its synthesis, physical properties, and degradation are also discussed here. Although it is relatively new in biomedical applications, it is readily usable for the fabrication of differing format of DDS of superior mechanical strength and degradation properties. The use of PTMCC is expected to increase in coming years as more is revealed about its potentials.