Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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N-Phenyl-3-Pyridin-2-yl Imino Derivatives as Vascular Smooth Muscle Relaxants: Potential Phosphodiesterase V Inhibitors

  • Choudhari, Prafulla (Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy) ;
  • Bhatia, Manish (Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy) ;
  • Bhatia, Neela (Department of Pharmaceutical Chemistry, Bharati Vidyapeeth College of Pharmacy)
  • Received : 2013.05.21
  • Accepted : 2013.06.19
  • Published : 2013.09.20
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Abstract

The present communication deals with development of ten novel N-Phenyl-3-Pyridin-2-yl imino derivatives as vascular smooth muscle relaxants. The derivatives were prepared and optimized using pocket modelling and pharmacophore modelling. The 4 hydroxy substituted derivatives are showed potent activity comparable to the sildenafil.

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References

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