Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Dynamic Contrast-Enhanced MR Imaging in Detecting Local Tumor Progression after HIFU Ablation of Localized Prostate Cancer

국소적 전립선암의 고강도 집속 초음파 치료 후 국소적 암 재발의 발견과 역동적 조영증강 자기공명영상의 역할

  • Park, Jung Jae (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Chan Kyo (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Hyun Moo (Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Byung Kwan (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Sung Yoon (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 박정재 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 김찬교 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 이현무 (성균관대학교 의과대학 삼성서울병원 비뇨기과) ;
  • 박병관 (성균관대학교 의과대학 삼성서울병원 영상의학과) ;
  • 박성윤 (성균관대학교 의과대학 삼성서울병원 영상의학과)
  • Received : 2013.03.31
  • Accepted : 2013.08.28
  • Published : 2013.09.30
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Abstract

Purpose : To retrospectively evaluate the diagnostic performance of dynamic contrast-enhanced MR imaging (DCE-MRI) in detecting recurrent prostate cancer after HIFU of clinically localized cancer, as compared with T2-weighted imaging (T2WI). Materials and Methods: Twenty-six patients with increased prostate-specific antigen levels after HIFU were included in this study. All MR examinations were performed using T2WI and DCE-MRI, followed by transrectal ultrasound-guided biopsy. MRI and biopsy results were correlated in six prostate sectors. Residual or recurrent cancer after HIFU was defined as local tumor progression if biopsy results showed any cancer foci. Two independent readers interpreted the MR images. Results: Of 156 prostate sectors, 51 (33%) were positive for cancer in 17 patients. For detecting local tumor progression, the sensitivity of DCE-MRI and T2WI was 80% and 57% for reader 1 (P < 0.001) versus 84% and 61% for reader 2 (P < 0.001), respectively. The specificity and overall accuracy between DCE-MRI and T2WI showed no statistical difference in both readers (P > 0.05). Interobserver agreement of DCE-MRI and T2WI was moderate and fair, respectively. Conclusion: For detecting local tumor progression of prostate cancer after HIFU, DCE-MRI was more sensitive than T2WI, with less interobserver variability.

목적: 국소적 전립선암의 고강도 집속 초음파 치료 후 국소적 암 재발을 발견하는데 있어 역동적 조영증강 자기공명영상의 진단적 능력을 T2 강조영상과 후향적으로 비교하고자 한다. 대상과 방법: 고강도 집속 초음파 치료을 시행 받은 이후 혈중 전립선 특이 항원 수치가 증가한 26명의 환자를 연구에 포함시켰다. 모든 환자는 T2 강조영상과 역동적 조영증강 자기공명영상을 시행 받은 후 경직장 초음파 유도하 조직 검사를 받았으며, 영상 소견과 조직 검사 결과는 전립선을 여섯 구획으로 분리 하여 비교하였다. 조직 검사 결과에서 암 병변이 있는 경우 국소적 암 재발로 정의하였으며, 영상 소견은 두 명의 독립적인 영상의학과 의사가 분석하였다. 결과: 156개의 전립선 구획에서 17명의 환자, 51 구획 (33%)에서 재발암 병변이 발견되었다. 국소적 암 재발의 발견에 있어 역동적 조영증강영상과 T2 강조영상의 민감도는 관찰자 1 에서 각각 80%와 57% (P < 0.001), 관찰자 2 에서 각각 84%와 61% (P < 0.001) 였다. 두 영상 방법간 특이도와 정확도는 두 관찰자에서 모두 유의한 차이가 없었다 (P > 0.05). 관찰자간 일치도에 있어 역동적 조영 증강 영상의 카파값은 0.52, T2 강조 영상의 카파값은 0.21 이었다. 결론: 국소적 전립선암의 고강도 집속 초음파 치료 후 국소적 암 재발을 발견하는데 있어 역동적 조영증강영상은 T2 강조영상보다 더욱 민감하며 관찰자간 일치도 역시 높다.

Keywords

References

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