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Anti-TNF-${\alpha}$ 치료를 받은 강직성 척추염 환자들의 체중과 골밀도 변화

Body Weight and Bone Density Changes in Patients with Ankylosing Spondylitis Receiving Anti-Tumor Necrosis Factor-${\alpha}$ Treatment

  • 이장원 (왈레스기념 침례병원 내과) ;
  • 정민석 (왈레스기념 침례병원 내과) ;
  • 김동현 (왈레스기념 침례병원 내과) ;
  • 이승현 (왈레스기념 침례병원 내과) ;
  • 오숙경 (왈레스기념 침례병원 내과) ;
  • 조영선 (왈레스기념 침례병원 내과) ;
  • 변상환 (왈레스기념 침례병원 내과) ;
  • 남경민 (왈레스기념 침례병원 내과) ;
  • 이충원 (왈레스기념 침례병원 내과)
  • Lee, Jangwon (Department of Internal Medicine, Wallace Memorial Baptist Hospital) ;
  • Jung, Minsuk (Department of Internal Medicine, Wallace Memorial Baptist Hospital) ;
  • Kim, Donghyun (Department of Internal Medicine, Wallace Memorial Baptist Hospital) ;
  • Lee, Seunghyun (Department of Internal Medicine, Wallace Memorial Baptist Hospital) ;
  • Oh, Sook Kyung (Department of Internal Medicine, Wallace Memorial Baptist Hospital) ;
  • Jo, Youngsun (Department of Internal Medicine, Wallace Memorial Baptist Hospital) ;
  • Byun, Sanghwan (Department of Internal Medicine, Wallace Memorial Baptist Hospital) ;
  • Nam, Kyoungmin (Department of Internal Medicine, Wallace Memorial Baptist Hospital) ;
  • Lee, Choongwon (Department of Internal Medicine, Wallace Memorial Baptist Hospital)
  • 투고 : 2012.12.24
  • 심사 : 2013.06.07
  • 발행 : 2013.11.01

초록

목적: 본 연구의 목적은 강직성 척추염 환자에서 anti-tumor necrosis factor-${\alpha}$ (anti-TNF-${\alpha}$) 치료 후의 체중과 골밀도의 변화를 알아보고자 연구를 하였다. 방법: Modified New York Criteria에 의해 진단된 총 31명의 (남성 25명, 여성 6명) 강직성 척추염 환자들을 대상으로 하였다. 모든 환자들은 비스테로이드성 소염진통제(NSAIDs), sulfasalazine, methotrexate에도 반응하지 않고 질병활성도가 높아 anti-TNF-${\alpha}$ 치료를 2년 이상 시행하였다. Anti-TNF-${\alpha}$의 용량은 etanercept 25 mg 주 2회였고 adalimumab 40 mg 월 2회로 하였다. 체중과 골밀도를(dual energy X-ray absorptiometry) 비롯하여 질병활성도의 지표로 Bath ankylosing spondylitis (BASDAI), C-reactive protein (CRP), Erythrocyte sedimentation rate (ESR) 등을 측정하였다. 결과: TNF-${\alpha}$ 길항제 치료 전과 비교했을 때 치료 1년 후와 2년 후의 몸무게의 평균은 $68.6{\pm}13.2kg$, $69.2{\pm}15.2kg$로 p value가 0.02로 통계적으로 유의한 차이를 보였으며 시간이 갈수록 값이 증가함을 알 수 있다(Fig. 1). TNF-${\alpha}$ 길항제 치료 전 요추부(제1-제4요추) 평균 골밀도는 $-0.2{\pm}1.6$이었고 치료 1년 후와 2년 후의 요추부 평균 골밀도는(Z-score로 변환 시) 각각 $0.1{\pm}1.6$, $0.2{\pm}1.6$으로 p value가 0.001이하로 통계적으로 매우 유의한 차이를 보였으며 시간이 갈수록 값이 증가함을 알 수 있다(Fig. 1). TNF-${\alpha}$ 길항제 치료 전 BASDAI는 $5.6{\pm}2.8$점이었고 치료 1년 후와 2년 후는 각각 $2.3{\pm}1.9$점, $2.0{\pm}1.8$점으로 p value가 0.01 미만으로 통계적으로 매우 유의한 감소 양상을 보였다. CRP는 TNF-${\alpha}$ 길항제 치료 전 $1.4{\pm}2.0mg/dL$였고 치료 1년 후와 2년 후는 각각 $0.3{\pm}0.3mg/dL$, $0.5{\pm}1.0mg/dL$로 p value가 0.01 미만으로 통계적으로 유의한 차이를 보였다. 결론: 강직성 척추염 환자들을 대상으로 한 골밀도와 체중의 변화에 대한 국내 자료는 외국에 비해 미미한 실정이다. 본 연구에서는 31명의 강직성 척추염 환자들을 대상으로 TNF-${\alpha}$ 길항제 치료 후 체중과 요추부 골밀도가 통계적으로 유의하게 증가함과 동시에 질병활성도의 지표의 BASDAI가 통계적으로 유의하게 감소하는 것을 확인하였기에 보고하는 바이다.

Background/Aims: To determine the changes in body weight and bone mineral density in patients with ankylosing spondylitis (AS) receiving anti-tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) treatment. Methods: Thirty-one patients with AS (25 males and 6 females) who fulfilled the Modified New York Criteria for AS were included in this retrospective study. All patients had active disease that eventually required anti-TNF-${\alpha}$ treatment. Each patient received anti-TNF-${\alpha}$ treatment (etanercept 25 mg twice weekly or adalimumab 40 mg twice monthly) for more than 2 years. Body weight, disease activity as Bath ankylosing spondylitis disease activity index (BASDAI), C-reactive protein, erythrocyte sedimentation rate (ESR), lumbar bone mineral density (LBMD), and femoral bone mineral density (FBMD) were measured at baseline and at 1 and 2 years after initiating anti-TNF-${\alpha}$ treatment. Results: There was a significant increase in mean body weight at 1 year ($1.1{\pm}3.8kg$) and at 2 years ($1.7{\pm}4.8kg$) compared with baseline. The gains in mean BMD of the lumbar spine were significant at 1 year ($0.4{\pm}0.4$) and 2 years ($0.5{\pm}0.7$) compared with baseline. Mean BMD of the femur was also increased at 1 year ($0.08{\pm}0.7$) and 2 years ($0.1{\pm}0.8$) compared with baseline, but these differences were not statistically significant. There were significant decreases in BASDAI at 1 year ($-3.3{\pm}2.8$) and at 2 years ($-3.6{\pm}2.8$) compared with baseline. Conclusions: This study showed significant increases in body weight, lumbar BMD, and BASDAI at 1 year and 2 years in patients with ankylosing spondylitis after receiving anti-TNF-${\alpha}$ treatment.

키워드

참고문헌

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피인용 문헌

  1. Weight Gain and Improvement of Osteoporosis with Anti-TNF Therapy vol.85, pp.5, 2013, https://doi.org/10.3904/kjm.2013.85.5.485