The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Bogijetong-Tang on Diabetic-peripheral Neuropathy Induced by Streptozotocin in the Mouse

보기제통탕(補氣除痛湯)이 Streptozotocin으로 유발된 당뇨병성 말초신경병증 동물 모델에 미치는 영향

  • Lee, Jong Bin (Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University) ;
  • Kim, Chul Jung (Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University) ;
  • Cho, Chung Sik (Dept. of Internal Medicine, College of Oriental Medicine, Dae-Jeon University)
  • 이종빈 (대전대학교 부속 천안한방병원 신계내과학교실) ;
  • 김철중 (대전대학교 부속 천안한방병원 신계내과학교실) ;
  • 조충식 (대전대학교 부속 천안한방병원 신계내과학교실)
  • Received : 2013.07.14
  • Accepted : 2013.09.16
  • Published : 2013.09.30
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Abstract

Objectives: Previous reports have shown that Bogijetong-Tang (BJT) is effective in peripheral neuropathy induced by taxol and crush injury. In this study, we researched the effects of BJT on diabetic neuropathy induced by STZ in the mouse. Methods: We performed both in vitro and in vivo experiments to verify the effects of BJT on diabetic neuropathy induced by STZ in mice. Changes in axonal recovery were observed with immunofluorescence staining using NF-200, Hoechst33258, $S100{\beta}$, caspase 3 and anti-cdc2. Proliferation and degeneration of Schwann cells were investigated by immunofluorescence staining and western blot analyses. Results: BJT showed considerable effects on neurite outgrowth and axonal regeneration in diabetic neuropathy. BJT contributed to the creation of NF-200, GAP-43, Cdc2, phospho-vimentin, ${\beta}1$, active ${\beta}1$, ${\beta}3$ integrin, phospho-Erk1/2 protein. Conclusions: Through this study, we found that BJT is effective for enhanced axonal regeneration via dynamic regulation of regeneration-associated proteins. Therefore, BJT had a pharmaceutical property enhancing recovery of peripheral nerves induced by diabetic neuropathy and could be a candidate for drug development after more research.

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References

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