The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지
DOI QR코드

DOI QR Code

Anti-inflammatory Effect of Zeae Stigma Herbal-acupuncture at KI10 on LPS-induced Nephritis in Rats

음곡 옥미수 약침이 LPS로 유도된 흰쥐의 신장염에 미치는 영향

  • Kim, Yang-Seob (Dept. of Meridians & Acupoints, College of Oriental Medicine, Daejeon University) ;
  • Yim, Yun-Kyoung (Dept. of Meridians & Acupoints, College of Oriental Medicine, Daejeon University)
  • 김양섭 (대전대학교 한의과대학 경락경혈학교실) ;
  • 임윤경 (대전대학교 한의과대학 경락경혈학교실)
  • Received : 2013.03.15
  • Accepted : 2013.05.20
  • Published : 2013.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: The purpose of this study was to investigate the effects of Zeae Stigma herbal-acupuncture (ZS-HA) at KI10 (Umgok) on nephritis induced by lipopolysaccharide (LPS) in rats. Methods: Rats were assigned to five groups, normal, LPS, NP, saline and ZS-HA. Rats in NP, saline, and ZS-HA groups were treated with needle prick, saline injection, and ZS-HA respectively at KI10, three times a week. All animals except the normal group were injected intra-peritoneally with LPS to induce nephritis. RBC and WBC, neutrophils in blood, TNF-alpha, CINC-1, creatinine in serum, urinal volume, total protein and creatinine in urine, and renal MPO were analyzed. Results: Needle prick at KI10 significantly reduced WBC in blood and CINC-1 in serum of LPS-stimulated rats. Saline injection at KI10 significantly reduced TNF-${\alpha}$ in serum and total protein in urine of LPS-stimulated rats. ZS-HA at KI10 significantly increased RBC in blood, and significantly reduced neutrophils in blood, TNF-${\alpha}$ in serum, and total protein in urine of LPS-stimulated rats. Conclusions: According to these results, it is postulated that ZS-HA at KI10 has anti-inflammatory and renal-protective effects on LPS-induced nephritis in rats, and both acupoint KI10 and herb Zeae Stigma made contributions to this effect. Further studies on the interaction between acupoint KI10 and herb Zeae Stigma may be needed.

Keywords

References

  1. Du HK. Oriental Kidney System Internal Medicine. Seoul : Oriental Science Research Association. 1993 : 226, 228, 247, 238-47, 326, 334-6.
  2. Lee WJ. Medical Dictionary. The 2nd Edition. Seoul:Academy Press. 2000: 724.
  3. J. CLAUDE bennett, FRED PLUM. Cecil textbook of medicine. 20th. philadelphia : saunders. 1996 : 552, 575-7.
  4. Frequent 22 Disease Classification Payroll Status. 200 4-2011. Available at: URL:http://stat.kosis.kr/nsieu/vie w/tree.do?task=branchView&id=350_35001_6*MT_O TITLE&hOrg=350. Accessed October 2, 2012
  5. Acute Glomerulonephritis. 2005. Available at: URL: http ://www.amc.seoul. kr/dept/bbs/view.do?dtCode=D022&dtType=F&menuId=5897&id=6 2466. Accessed October 2, 2012.
  6. Seo SJ. Diagnosis and Management of the Renal Diseases Treatment of Glomerulonephritis . The Korean Journal of Medicine. 1962;5(2):81-5.
  7. Hong SK. Diagnosis and Management of the Renal Diseases Theoretical Analysis of Plasma Clearance Concept . The Korean Journal of Medicine. 1962;5(2): 75-8.
  8. Kim YI. Symposium : Management of the Idiopathic Nephrotic Syndrome in Adults . The Korean Journal of Medicine. 1978;21(10):811-9.
  9. Lee BY. Diagnosis and Management of the Renal Diseases : Nephrotic Syndrome. The Korean Journal of Medicine. 1962;5(3):141-4.
  10. Meridians & Acupoints Compilation Committee of Korean Oriental Medical Colleges. Details of Meridians & Acupoints ; A Guidebook for College Students. Daejeon:Jongryeonamu Publishing Co. 2012:634-6.
  11. Committee of Korean Textbook Publisher. Herbology. Seoul: Yeong Lim Sa. 2004: 353-4.
  12. Yoon HJ. The Glucoregulstory Effects of MAYDIS STIGMATA in Streptozotocin Induced Diabetic Rats. The Journal of Jeahan Oriental Medical Academy. 1995; 1(1): 178-87.
  13. Cho JH. Effect of Zeae Stigma on Renal injury induced by Gentamicin Sulfate in rats. J. of Herbology. 1994; 9(1): 143-57.
  14. Park BM, Hur B, Yim YK. Anti-inflammatory Effect of Plantaginis Semen Herbal-acupuncture at KI10 on LPS-induced nephritis in rats. Journal of Meridian & Acupoint. 2009; 26(2): 127-143.
  15. Cho E, Kang JH, Lee H. Anti-inflammatory Effect of Akebiae Lignum Parmacopuncture at KI10 on LPS-induced Acute Nephritis in Rats. The Journal of Korean Acupuncture & Moxibustion Society. 2012;29(3): 41-53.
  16. Kim KM, Lee H, Kang HJ, Lee YH, Yim YK. Anti-inflammatory Effect of Dianthi Semen Herbal-acupuncture at KI10 on nephritis in rats . Journal of Meridian & Acupoint. 2009;26(1): 61-77.
  17. Glauser MP, Zanetti G, Baumgartner JD, Cohen J. Septic shock Pathogenesis. Lancet. 1991;338: 732-6. https://doi.org/10.1016/0140-6736(91)91452-Z
  18. Ohmori Y, Hamilton TA. Amacrophage LPS-inducible early gene encodes the murine homologue of IP-10. Biochem Biophys Res Commun. 1990; 168: 1261-7. https://doi.org/10.1016/0006-291X(90)91164-N
  19. Tannenbaum CS, Koemer TJ, Jansen MM, Hamilton TA. Characteriation of Lipopolysaccharide-induced macrophage gene expression. J immunol. 1988; 140 : 3640-5.
  20. Jung HJ, Lim CG, Go GS, Ahn JH, Lee TW, Kim MJ, et al. Effects of Angiotensin - Converting Enzyme Inhibition ( ACEi ) in Serum HBsAg ( + ) Glomerulonephritis ( GN )), The Korean Journal of Medicine. 1994; 46(6): 817-825
  21. No JU. Therapeutic Guidelines of Rapidly progressive Glomerulonephritis, IgA Nephropathy, Membranoproliferative Glomerulonephritis. The Korean Journal of Nephrology. 2001; 20(suppl 3): 354-369
  22. Lee KW. Blood pressure control in chronic kidne y disease. 7. Available at: URL: http://www.medi fonews.com/news/bbs.html?bcode=imsang. Acce ssed October 2, 2012
  23. Kang MS, Kim HR, Kim SK. Physiology. Seoul: Korea national Open University Press. 2003: 72-76, 97-108.
  24. Kim JH, Yang KS. Effects of Polygonatum odoratum on Mercuric Chloride Induced Renal Failure Rats. Natutal Product Sciences. 2002; 33(3): 200-206.
  25. Nakagawa H, Komori N, Shibata F, Ikesue A, Konishi K, Fujioka M, et al. Identification of cytokineinduced neutrophil chemoattractants (CINC), rat GRO/CINC-2 alpha and CINC-2 beta, produced by granulation tissue in culture: purification, complete amino acid sequences and characterization. Biochem. J. 1994 ; 301: 545
  26. Taie S, Chujo K, Asaga T, Iwanaga Y, Ono J, Maekawa N. Urinary trypsin inhibitor reduces inflammatory response in kidney induced by lipopolysaccharide. Ueki J Biosci Bioeng. 2007 ; 104(4) : 315-20. https://doi.org/10.1263/jbb.104.315
  27. Lee KN, Kwon OH. Clinical Pathology File. Seoul: Medical Culture Press. 2003: 95-8, 102-5, 1437.

Cited by

  1. 음곡에 시술한 석위약침이 Lipopolysaccharide로 유도된 흰쥐의 신장염에 미치는 영향 vol.32, pp.3, 2013, https://doi.org/10.13045/acupunct.2015035