대한기계학회논문집B (Transactions of the Korean Society of Mechanical Engineers B)

  • 제36권11호
  • /
  • Pages.1081-1090
  • /
  • 2012
  • /
  • 1226-4881(pISSN)
  • /
  • 2288-5324(eISSN)
대한기계학회 (The Korean Society of Mechanical Engineers)
권호 표지
DOI QR코드

DOI QR Code

외상성 관절염 진행에 따른 경골 골단 해면골에서의 골 미세구조 변화 패턴 추적 관찰

Longitudinal Tracking of Alteration Pattern on Trabecular Bone Microarchitecture at Tibial Epiphysis Induced by Post Traumatic Osteoarthritis Over Time

  • 이주형 (세종대학교 기계공학과) ;
  • 전경진 (한국생산기술연구원 실버기술연구그룹) ;
  • 이권용 (세종대학교 기계공학과) ;
  • 김대준 (세종대학교 신소재공학과) ;
  • 김한성 (연세대학교 의공학과) ;
  • 임도형 (세종대학교 기계공학과)
  • 투고 : 2012.03.21
  • 심사 : 2012.07.20
  • 발행 : 2012.11.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

외상성 관절염 발생시 슬관절에서의 해면골 미세구조 변화 특성에 대한 연구는 부족한 실정이다. 따라서 본 연구에서는 생체 내 미세 단층 촬영을 통해, 소동물(SD rat; 10 마리)의 경골 골단 해면골 미세구조 변화패턴을 연속적으로 추적 관찰하여 정량적으로 분석하였다. 외상성 관절염 군(5 마리)에는 전방십자인대절제술을 실시하였고, 정상군(5 마리)에는 아무런 외과적 처치를 가하지 않았다. 외상성 관절염군은 정상군과 비교시 수술후 8 주까지 약 4-16%의 유의한 골 미세구조 차이를 나타내었다(P<0.05). 동일 기간 동안 골 밀집 정도 및 골 형성 정도는 5-15% 정도로 유의한 차이를 나타내었다(P<0.05). 본 연구는 외상성 관절염 발생에 의한 경골 골단 해면골의 골 미세구조 변화 특성 기준 정립 및 외상성 관절염의 이해와 치료에 도움이 될 것으로 기대된다.

This study aims to track the longitudinal alteration pattern on the trabecular bone microarchitecture at tibial epiphysis induced by T-OA over time using in vivo micro computed tomography (${\mu}CT$). Ten SD rats were divided into control (n = 5) and T-OA (n = 5) groups. Anterior cruciate ligament transaction was performed for the T-OA group. The results showed that the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis in the T.OA group was definitely different compared with that in the CON group from 0 to 8 weeks (approximately 4-16%, P > 0.05). In particular, a difference was observed in the bone formation and density distributions over time (from 0 or 4 to 8 weeks; approximately 5.15%, P < 0.05). An improved understanding of the alteration pattern on the trabecular bone microarchitecture at tibial epiphysis may assist in developing more targeted treatment interventions for T-OA.

키워드

참고문헌

  1. Gold, R. H., Bassett, L. W. and Seeger, L. L., 1988, "The Other Arthritides. Roentgenologic Features of Osteoarthritis, Erosive Osteoarthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Reiter's Disease, Multicentric Reticulohistiocytosis, and Progressive Systemic Sclerosis," Radiologic Clinics of North America, Vol. 26, No. 6, pp. 1195-1212.
  2. Buckwalter, J. A. and Brown, T. D., 2004. "Joint Injury, Repair, and Remodeling: Roles in Post-Traumatic Osteoarthritis," Clinical Orthopaedics and Related Research, No. 423, pp.7-16.
  3. Gelber, A. C., Hochberg, M. C., Mead, L. A., Wang, N. Y., Wigley, F. M. and Klag, M. J., 2000. "Joint Injury in Young Adults and Risk for Subsequent Knee and Hip Osteoarthritis," Annals of Internal Medicine 133, pp. 321-328. https://doi.org/10.7326/0003-4819-133-5-200009050-00007
  4. Lotz, M. K. and Kraus, V. B., 2010, "New Developments in Osteoarthritis. Posttraumatic Osteoarthritis: Pathogenesis and Pharmacological Treatment Options," Arthritis Research and Therapy, Vol. 12, No. 3, p. 211. https://doi.org/10.1186/ar3046
  5. Brown, T. D., Johnston, R. C., Saltzman, C. L., Marsh, J. L. and Buckwalter, J. A., 2006, "Posttraumatic Osteoarthritis: a First Estimate of Incidence, Prevalence, and Burden of Disease," Journal of Orthopaedic Trauma, Vol. 20, No. 10, pp. 739-744. https://doi.org/10.1097/01.bot.0000246468.80635.ef
  6. Gillquist, J. and Messner, K., 1999, "Anterior Cruciate Ligament Reconstruction and the Long-Term Incidence of Gonarthrosis," Sports Medicine, Vol. 27, No. 3, pp. 143-156. https://doi.org/10.2165/00007256-199927030-00001
  7. Roos, H., Adalberth, T., Dahlberg, L. and Lohmander, L. S., 1995, "Osteoarthritis of the Knee After Injury to the Anterior Cruciate Ligament or Meniscus: the Influence of Time and Age," Osteoarthritis and Cartilage, Vol. 3, No. 4, pp. 261-267. https://doi.org/10.1016/S1063-4584(05)80017-2
  8. Quatman, C. E., Kiapour, A., Myer, G. D., Ford, K. R., Demetropoulos, C. K., Goel, V. K. and Hewett, T. E., 2011, "Cartilage Pressure Distributions Provide a Footprint to Define Female Anterior Cruciate Ligament Injury Mechanisms," The American Journal of Sports Medicine, Vol. 39, No. 8, pp. 1706-1713. https://doi.org/10.1177/0363546511400980
  9. Bellido, M., Lugo, L., Roman-Blas, J. A.,Castaneda, S., Caeiro, J. R., Dapia, S., Calvo, E., Largo, R. and Herrero-Beaumont, G., 2010, "Subchondral Bone Microstructural Damage by Increased Remodelling Aggravates Experimental Osteoarthritis Preceded by Osteoporosis," Arthritis Research and Therapy, Vol. 12, No. 4, p. R152. https://doi.org/10.1186/ar3103
  10. Sniekers, Y. H., Intema, F., Lafeber, F. P., van Osch, G. J., van Leeuwen, J. P., Weinans, H. and Mastbergen, S. C., 2008, "A Role for Subchondral Bone Changes in the Process of Osteoarthritis; A Micro-CT Study of Two Canine Models," BMC Musculoskeletal Disorders, Vol. 9, p. 20. https://doi.org/10.1186/1471-2474-9-20
  11. Hayami, T., Pickarski, M., Wesolowski, G. A., McLane, J., Bone, A., Destefano, J., Rodan, G. A. and Duong le, T., 2004, "The Role of Subchondral Bone Remodeling in Osteoarthritis: Reduction of Cartilage Degeneration and Prevention of Osteophyte Formation by Alendronate in the Rat Anterior Cruciate Ligament Transection Model," Arthritis and Rheumatism, Vol. 50, No. 4, pp. 1193-1206. https://doi.org/10.1002/art.20124
  12. Boyd, S. K., Muller, R., Leonard, T. and Herzog, W., 2005, "Long-Term Periarticular Bone Adaptation in a Feline Knee Injury Model for Post-Traumatic Experimental Osteoarthritis," Osteoarthritis and Cartilage, Vol. 13, No. 3, pp. 235-242. https://doi.org/10.1016/j.joca.2004.11.004
  13. Boyd, S. K., Matyas, J. R., Wohl, G. R., Kantzas, A. and Zernicke, R. F., 2000, "Early Regional Adaptation of Periarticular Bone Mineral Density After Anterior Cruciate Ligament Injury," Journal of Applied Physiology, Vol. 89, No. 6, pp. 2359-2364.
  14. Leppala, J., Kannus, P., Natri, A., Pasanen, M., Sievanen, H., Vuori, I. and Jarvinen, M., 1999, "Effect of Anterior Cruciate Ligament Injury of the Knee on Bone Mineral Density of the Spine and Affected Lower Extremity: A Prospective One-Year Follow-Up Study," Calcified Tissue International, Vol. 64, No. 4, pp. 357-363. https://doi.org/10.1007/s002239900632
  15. McErlain, D. D., Appleton, C. T., Litchfield, R. B., Pitelka, V., Henry, J. L., Bernier, S. M., Beier, F. and Holdsworth, D. W., 2008, "Study of Subchondral Bone Adaptations in a Rodent Surgical Model of OA Using in Vivo Micro-Computed Tomography," Osteoarthritis and Cartilage, Vol. 16, No. 4, pp. 458-469. https://doi.org/10.1016/j.joca.2007.08.006
  16. Williams, J. M., Felten, D. L., Peterson, R. G. and O'Connor, B. L., 1982, "Effects of Surgically Induced Instability on Rat Knee Articular Cartilage," Journal of Anatomy, Vol. 134, No. Pt 1, pp. 103-109.
  17. Dempster, D. W., 2000, "The Contribution of Trabecular Architecture to Cancellous Bone Quality," Journal of Bone and Mineral Research, Vol. 15, No. 1, pp. 20-23. https://doi.org/10.1359/jbmr.2000.15.1.20
  18. Manidakis, N., Dosani, A., Dimitriou, R., Stengel, D., Matthews, S. and Giannoudis, P., 2010, "Tibial Plateau Fractures: Functional Outcome and Incidence of Osteoarthritis in 125 Cases," International Orthopaedics, Vol. 34, No. 4, pp. 565-570 https://doi.org/10.1007/s00264-009-0790-5
  19. Rogers, M. P., Trentham, D. E., McCune, W. J., Ginsberg, B. I., Rennke, H. G., Reich, P. and David, J. R., 1980, "Effect of Psychological Stress on the Induction of Arthritis in Rats," Arthritis and Rheumatism, Vol. 23, No. 12, pp. 1337-1342. https://doi.org/10.1002/art.1780231202
  20. Smith, M.M. and Little, C.B., 2007. Experimental Models of Osteoarthritis, in: Moskowitz, R.W., Altman, R.D., Hochberg, M.C., Buckwalter, J.A., Goldberg, V.M., Osteoarthritis: Diagnosis and Medical/Surgical Management, 4th edition, WB Saunders., Philadelpia, p. 118.
  21. Bray, R. C., Doschak, M. R., Gross, T. S. and Zernicke, R. F., 1997, "Physiological and Mechanical Adaptations of Rabbit Medial Collateral Ligament After Anterior Cruciate Ligament Transection," Journal of Orthopaedic Research, Vol. 15, No. 6, pp. 830-836. https://doi.org/10.1002/jor.1100150607
  22. Wexler, G., Hurwitz, D. E., Bush-Joseph, C. A., Andriacchi, T. P. and Bach, B. R., Jr., 1998, "Functional Gait Adaptations in Patients with Anterior Cruciate Ligament Deficiency over Time," Clinical Orthopaedics and Related Research, No. 348, pp. 166-175.