Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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A Green One-Pot Protocol for Regioselective Synthesis of New Substituted 7,8-Dihydrocinnoline-5(6H)-ones

  • Khalafy, Jabbar (Department of Chemistry, Urmia University) ;
  • Rimaz, Mehdi (Department of Chemistry, Payame Noor University) ;
  • Ezzati, Mahnaz (Department of Chemistry, Urmia University) ;
  • Prager, Rolf H. (School of Chemistry, Physics and Earth Sciences, Flinders University)
  • Received : 2012.05.07
  • Accepted : 2012.05.26
  • Published : 2012.09.20
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Abstract

A simple regioselective synthesis of cinnoline derivatives was achieved by a one-pot three component synthetic methodology. New substituted 7,8-dihydrocinnolin-5(6H)-ones are prepared via one-pot three component reaction of arylglyoxals with 1,3-cyclohexanedione and dimedone in the presence of hydrazine hydrate in moderate to good yields.

Keywords

References

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  7. Crystal structure of 4-(4-((3-bromophenyl)amino)-6-(tert-butyl)-3-(2-hydroxypropan-2-yl)cinnolin-8-yl)-2-methylbut-3-yn-2-ol, C26H30BrN3O2 vol.231, pp.4, 2012, https://doi.org/10.1515/ncrs-2016-0138
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