The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Effects of Pinelliae Rhizoma(PR) on Ovarian Tissue in Polycystic Ovary Syndrome(PCOS) Rats

반하(半夏)가 다낭성 난소 증후군이 유발된 흰쥐의 난소 조직에 미치는 영향

  • Yeo, Eun-Ju (Dept. of Oriental Obstetric and Gynecology, College of Oriental Medicine, Dong-Sin University) ;
  • Jo, Sung-Hee (Dept. of Oriental Obstetric and Gynecology, College of Oriental Medicine, Dong-Sin University) ;
  • Yang, Seung-Jung (Dept. of Oriental Obstetric and Gynecology, College of Oriental Medicine, Dong-Sin University) ;
  • Park, Kyung-Mi (Dept. of Oriental Obstetric and Gynecology, College of Oriental Medicine, Dong-Sin University)
  • 여은주 (동신대학교 한의과대학 부인과학 교실) ;
  • 조성희 (동신대학교 한의과대학 부인과학 교실) ;
  • 양승정 (동신대학교 한의과대학 부인과학 교실) ;
  • 박경미 (동신대학교 한의과대학 부인과학 교실)
  • Received : 2012.04.24
  • Accepted : 2012.05.15
  • Published : 2012.05.25
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Abstract

Objectives: This study was designed to investigate the effects of PR on ovarian tissue in PCOS rats through measurement of morphological and histo-pathological observations, ovarian size. In addition, effects on expression levels of Insulin like Growth Factor Receptor(IGFR) were also investigated to elucidate related mechanisms. Methods: PCOS was induced by single intermuscular injection with ${\beta}$-Estradiol 17-Valerate(EV) in female rats. Normal group(NOR, n=8) were injected with sesame oil and administrated hard food for five weeks. Control group(CTL, n=8) were injected with EV and administrated hard food for five weeks. CR group(n=8) were injected with EV and administrated hard food mixed CR for five weeks. Then, we measured weights of body and ovary, uptakes of food and water. And we observed morphological and histo-pathological changes of ovary, levels of IGFR. Results: In this experiments, single injection of Estradiol Valerate(EV) induced suppression of weight gain, formation of cysts, increase of IGFR expression. Oral administration of PR prevent decrease of ovarian size significantly. Further more, formation of cystic follicles induced by EV injection is suppressed by PR treatment. Conclusions: These results suggest PR can be used for patients with PCOS to prevent formation of cystic follicles and malfunction of ovary.

Keywords

References

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