The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of pear ethanol extract on asthma induced by ovalbumin in mice

배 에탄올 추출물이 난황에 의하여 유발된 생쥐의 천식에 미치는 영향

  • Chung, Hee-Jin (School of Korean medicine, Pusan National University) ;
  • Joung, Young-Min (School of Korean medicine, Pusan National University) ;
  • Choi, Eu-Gene (School of Korean medicine, Pusan National University) ;
  • Shin, Dong-Sung (School of Korean medicine, Pusan National University) ;
  • Kim, Hyung-Woo (School of Korean medicine, Pusan National University) ;
  • Cho, Su-In (School of Korean medicine, Pusan National University)
  • 정희진 (부산대학교 한의학전문대학원) ;
  • 정영민 (부산대학교 한의학전문대학원) ;
  • 최유진 (부산대학교 한의학전문대학원) ;
  • 신동선 (부산대학교 한의학전문대학원) ;
  • 김형우 (부산대학교 한의학전문대학원) ;
  • 조수인 (부산대학교 한의학전문대학원)
  • Received : 2011.12.07
  • Accepted : 2012.01.13
  • Published : 2012.01.30
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Abstract

Objectives : In the theory of Korean medicine, Pear has long been considered to protect throat, bronchus and lung. Pear has been believed to remove sputum in Korean people. This study was conducted to investigate the effect of pear ethanol extract (PEE) on asthma induced by ovalbumin in mice. Methods : We investigated the effects of PEE on airway hyperresponsiveness to methacholine, production levels of ovalbumin (OVA) specific total immunoglobulin G (IgG), IgG1, IgG2a and IgE in serum and histopathological changes of lung tissues in asthamtic mice. Results : PEE decreased airway hyperresponsiveness to methacholine significantly compared to non-treated asthmatic mice (P<0.05). Level of OVA specific IgE in serum was lowered by oral administration of PEE effectively (P<0.05). In histopathological observation, administration of PEE reduced infiltration of immune cells into lung tissue. Conclusion : These results suggest that pear has anti-asthmaitc action and related mechanims are involved in anti-inflammatory action such as reducing level of OVA specific IgE and immune cell infiltration.

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References

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