The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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The effect of Gihyeolgwanjeolbang-A(CWS-A) on adjuvant-induced arthritis in rats

기혈관절방(氣血關節方)A(CWS-A)가 CFA로 유발(誘發)된 관절염(關節炎)에 미치는 영향(影響)

  • Na, Chang-Su (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University) ;
  • Youn, Dae-Hwan (Dept. of Acupoint & Meridian, Oriental Medical School, Dongshin University) ;
  • Kim, Jeong-Sang (Dept. of Anatomy, Oriental Medical School, Dongshin University) ;
  • Chae, Woo-Seok (Dept. of Acupuncture, Oriental Medical School, Dongshin University)
  • 나창수 (동신대학교 한의과대학 경혈학교실) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 김정상 (동신대학교 한의과대학 해부학교실) ;
  • 채우석 (동신대학교 한의과대학 침구학교실)
  • Received : 2011.12.15
  • Accepted : 2012.01.13
  • Published : 2012.01.30
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Abstract

Objective : To investigate effects of herbal preparations formulated(Gihyeolgwanjeolbang-A, CWS-A) on complete Freund's adjuvant (CFA)-induced arthritis in rats. Method : Arthritis was induced by injecting CFA subcutaneously into the left knee joint and paw, and the herbal preparations formulated(CWS-A I, 82.3 mg/kg ; CWS-A II, 164.6 mg/kg) was administered orally (i.g.) for 10 consecutive days beginning on day 10 after the injection. External shape, paw edema, inflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), and histological observation were assessed. Result : In swelling of the paw, CWS-A I and CWS-A II group in 15 days and 20 days were significantly reduced compared to controls. In serum ALT, CWS-A I and CWS-A II group were significantly reduced compared to controls. In TNF-${\alpha}$, CWS-A I and CWS-A II group were a tendency reduced compared to controls. In HGB, HCT, MCHC of erythrocytes, CWS-A II group was increased compared to controls. In histological observations, CWS-A II group was observed synoviocytes more than control group and was observed proteoglycans in the deep layers. Conclusion : The data suggest that CWS-A significant anti-arthritic effects that may be mediated by suppressing inflammatory parameters.

Keywords

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