Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Effects of Polygoni Multiflori Radix (PMR) on Osteogenesis and Osteoclasts in vitro

하수오 물 추출물이 골형성 및 파골세포에 미치는 영향

  • 도윤정 (농촌진흥청 국립축산과학원) ;
  • 구세광 (대구한의대학교 한의과대학) ;
  • 김홍태 (부산광역시 보건환경연구원) ;
  • 오태호 (경북대학교 수의과대학) ;
  • 조영무 (농촌진흥청 국립축산과학원) ;
  • 김상우 (농촌진흥청 국립축산과학원) ;
  • 유일선 (농촌진흥청 국립축산과학원) ;
  • 이근우 (경북대학교 수의과대학)
  • Accepted : 2011.08.27
  • Published : 2011.08.30
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Abstract

Polygoni Multiflori Radix (PMR) a dried root tuber of Polygonum multiflorum Thunberg with bioactivities in bone metabolism is one of the most famous tonic traditional medicines in China, Japan and Korea.To observe the anti-osteoporotic effect of PMR, we observed the effects on proliferation and alkaline phosphatase (ALP) activity of primary osteoblasts, bone nodule formation, pit formation of osteoclasts and osteoclastogenesis in vitro. As the result of that, although PMR extracts have no meaningful changes on the the proliferation of primary osteoblasts, significant (p < 0.01) increases of ALP acitivity of osteoblasts were dose-dependently observed in all PMR extracts treated groups tested compared to that of vehicle control. It means that it enhanced the differentiation (ALP activity) and bone nodule formation of osteoblast. In addition, PMR extracts dose-dependently inhibits the pit formation and the number of multinucleated osteoclast-like cells (OCLs), osteoclastogenesis in vitro. Therefore these results show the possibility of PMR extracts as another anti-osteoporotic agents.

Keywords

References

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