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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Direct effect of protein kinase C inhibitors on cardiovascular ion channels

  • Son, Youn-Kyoung (Department of Physiology, Kangwon National University School of Medicine) ;
  • Hong, Da-Hye (Department of Physiology, Kangwon National University School of Medicine) ;
  • Kim, Dae-Joong (Department of Anatomy and Cell Biology, Kangwon National University School of Medicine) ;
  • Firth, Amy L. (The Salk Institute of Biological Studies) ;
  • Park, Won-Sun (Department of Physiology, Kangwon National University School of Medicine)
  • Received : 2011.09.02
  • Published : 2011.09.30
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Abstract

Protein kinase C (PKC) is a central enzyme that modulates numerous biological functions. For this reason, specific PKC inhibitors/activators are required to study PKC-related signaling mechanisms. To date, although many PKC inhibitors have been developed, they are limited by poor selectivity and nonspecificity. In this review, we focus on the nonspecific actions of PKC inhibitors on cardiovascular ion channels in addition to their PKC-inhibiting functions. The aim of this paper is to urge caution when using PKC inhibitors to block PKC function. This information may help to better understand PKC-related physiological/biochemical studies.

Keywords

References

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