Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Effect of Plant Part Extracts of Lythrum salicaria L. on Chronically Alcohol-Administrated Rat

털부처꽃 채취부위별 추출물이 만성 알코올 투여 흰쥐에 미치는 영향

  • Lee, Seung-Eun (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Kim, Geum-Soog (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Lee, Jeong-Hoon (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Kang, Yong-Ku (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Lee, Eun-Suk (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Choi, Je-Hun (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Lee, A-Reum (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Park, Su-Jin (Eco-Friendly Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Noh, Hyung-Jun (Department of Herbal Crop Research, NIHHS, RDA) ;
  • Kim, Seung-Yu (Department of Herbal Crop Research, NIHHS, RDA)
  • 이승은 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 김금숙 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 이정훈 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 강용구 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 이은숙 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 최재훈 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 이아름 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 박수진 (한국생명공학연구원 친환경바이오소재연구센터) ;
  • 노형준 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 김승유 (농촌진흥청 국립원예특작과학원 인삼특작부)
  • Received : 2011.09.06
  • Accepted : 2011.10.04
  • Published : 2011.10.30
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Abstract

The study was done to investigate the effects of the extracts from the different parts of Lythrum salicaria (LS) on liver protective activities in chronically alcohol-treated rats. SD male rats except normal animals were administrated with alcohol ($30m{\ell}$ of 30%~40% ethanol/kg/day) and the extracts (300 mg/kg/day) for 10 weeks. Chronic alcohol administration decreased body weight, high density lipoprotein (HDL)-cholesterol and the reduced form-glutathione (GSH), whereas increased the ethanol content, glutamic-oxaloacetic transaminase (GOT), total cholesterol, low density lipoprotein (LDL)- cholesterol, triglyceride in blood/serum and the ratio of the oxidized form of glutathione (GSSG) and total GSH (GSSG/total GSH) in liver tissue. Groups treated with the extracts of leaf, root and stem, showed decrease in GOT, total cholesterol and GSSG/total GSH and increase in hepatic aldehyde dehydrogenase (ALDH), total GSH and serum albumin. Administration with the root extract of LS decreased blood ethanol content compared with the other part extracts. But, serum triglyceride values in rats treated with root and stem extract were higher than that of the negative control animals. Flower extract-fed group showed decrease in body weight and serum triglyceride, but increase in the ratio of GOT and glutamic-pyruvic transaminase (GPT), and GSSG/total GSH. From the results, we conclude that the extracts of root and leaf among the plant parts of LS might be useful for the amelioration of the chronic alcohol-induced liver demage of rat.

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References

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