한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제15권3호
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  • Pages.215-221
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  • 2011
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
권호 표지

Mind Bomb1 and DeltaD are Localized into Autophagosome after Endocytosis in Zebrafish during Neurogenesis

  • Kim, Min-Jung (Research Institute of Medical Sciences, Chonnam National University)
  • 투고 : 2011.07.18
  • 심사 : 2011.07.30
  • 발행 : 2011.09.30
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초록

Endocytosis of the Notch ligand, DeltaD, by mind bomb1 is indispensable for activation of Notch in cell fate determination, proliferation, and differentiation during zebrafish neurogenesis. Loss of mind bomb1 activity as an E3 Ubiquitin ligase causes the accumulation of deltaD at the plasma membrane and results in the ectopic neurogenic phenotype by activation of Notch in early zebrafish embryogenesis. However, the regulatory mechanism of deltaD during neurogenesis is not identified yet. This study aims to analyze the pathway of mib1 and deltaD after endocytosis in vivo during zebrafish embryogenesis. Mind bomb1 and deltaD are co-localized into autophagosome and mutant form of mind bomb1 fails to cargo deltaD into autophagosomes. These findings suggest that mind bomb I mediates deltaD regulation by autophagy in an ubiquitin-dependent manner during zebrafish embryogenesis.

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참고문헌

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